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The Orexin/Hypocretin System pp 233–253Cite as

Canine Models of Narcolepsy

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Part of the book series: Contemporary Clinical Neuroscience ((CCNE))

Abstract

One of the major aims of the Stanford Sleep Research Center is to find the cause of human narcolepsy, a unique sleep disorder that affects 1 in 2000 of the general population. Since narcolepsy does not directly cause death, patients may ultimately pass away from an accident or illness, making the clinical-neuropathological correlation difficult to obtain from human subjects. Because of the nature and treatment of these accidents and unrelated illnesses patient specimens will generally not be available as uncontaminated neuropathological specimens of narcolepsy. The development of an animal model of narcolepsy was thus an urgent issue in the Stanford Sleep Research Center. In 1973, the Center had the extraordinary good fortune to acquire a female miniature French poodle who exhibited cataplexy and sleep onset rapid eye movement (REM) sleep periods (1). Active recruiting efforts resulted in the acquisition of additional narcoleptic dogs in small breeds, and finally in 1976, four narcoleptic Dobermans (two males and two females, including two litter mates) were obtained (2). With these multiple narcoleptic dogs, the Stanford Canine Narcolepsy Colony was established, and a breeding program was initiated (2).

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  1. Center for Narcolepsy, Stanford University School of Medicine, Palo Alto, CA

    Seiji Nishino MD, PhD

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  1. Center for Narcolepsy, Stanford University School of Medicine, Stanford, CA

    Seiji Nishino MD, PhD

  2. Department of Pharmacology Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan

    Takeshi Sakurai MD, PhD

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Nishino, S. (2006). Canine Models of Narcolepsy. In: Nishino, S., Sakurai, T. (eds) The Orexin/Hypocretin System. Contemporary Clinical Neuroscience. Humana Press. https://doi.org/10.1385/1-59259-950-8:233

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