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Hypocretin/Orexin Tonus and Vigilance Control

  • Chapter
The Orexin/Hypocretin System

Part of the book series: Contemporary Clinical Neuroscience ((CCNE))

Abstract

The importance of the hypocretin/orexin system in vigilance control has rapidly emerged from the discovery of narcolepsy genes in canines and mice and from the findings of ligand deficiency in human narcolepsy (1–4). (An earlier anatomical study suggested this involvement [5].) Narcolepsy, a chronic sleep disorder characterized by excessive daytime sleepiness, cataplexy, and dissociated manifestations of REM sleep (6), is now known to be caused by the loss of hypocretin neurotransmission. The loss could be caused either by a malfunction in hypocretin ligand production or by a loss of function of one of the two hypocretin receptors (i.e., hypocretin receptor 2/orexin 2 receptor) (1).

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Authors and Affiliations

  1. Department of Neuropsychiatry, Osaka Medical College, Takatsuki, Osaka, Japan

    Yasushi Yoshida MD, PhD

  2. Center for Narcolepsy, Stanford University School of Medicine, Palo Alto, CA

    Seiji Nishino MD, PhD

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  1. Yasushi Yoshida MD, PhD
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  2. Seiji Nishino MD, PhD
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Editors and Affiliations

  1. Center for Narcolepsy, Stanford University School of Medicine, Stanford, CA

    Seiji Nishino MD, PhD

  2. Department of Pharmacology Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan

    Takeshi Sakurai MD, PhD

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Yoshida, Y., Nishino, S. (2006). Hypocretin/Orexin Tonus and Vigilance Control. In: Nishino, S., Sakurai, T. (eds) The Orexin/Hypocretin System. Contemporary Clinical Neuroscience. Humana Press. https://doi.org/10.1385/1-59259-950-8:155

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