Hypocretin/Orexin and Motor Function
As the literature on hypocretin/orexin has grown, so has the list of functions attributed to this system. Recent papers have routinely listed sleep and arousal control, blood pressure regulation, feeding, motor control, and others as functions for the hypocretin system (1, 2, 3, 4). The question I address here is whether such an inclusive listing is an appropriate acknowledgement of the complexity and subtlety of hypocretin’s function or whether a simpler relationship may underlie the multiple correlations that have been seen.
KeywordsSleep Deprivation Locus Coeruleus Food Deprivation Amino Acid Release Active Waking
Unable to display preview. Download preview PDF.
- 6.Wu, M.F., John, J., Maidment, N., Lam, H.A., and Siegel, J.M. Hypocretin release in normal and narcoleptic dogs after food and sleep deprivation, eating, and movement. Am. J. Physiol. Regul. Integr. Comp. Physiol. 283, R1079–R1086Google Scholar
- 15.Mileykovskiy, B.Y., Kiyashchenko, L.I., and Siegel, J.M. (2000) Muscle tone facilitation and inhibition after orexin-A (hypocretin-1) microinjections into the medial medulla. J. Neurophysiol. 87, 2480–2489.Google Scholar