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Epidemiology of Status Epilepticus

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Part of the book series: Current Clinical Neurology ((CCNEU))

Abstract

Although prolonged seizure states have been recognized since ancient times, the frequency with which status epilepticus (SE) occurs was not fully appreciated until the last decade. Even in the 21st century, SE continues to challenge clinicians and investigators. Despite recent advances in its diagnosis and treatment, and the advent of sophisticated intensive care units, SE is associated with a persistently high mortality rate. Inpatient medical costs relating to SE have been estimated at $4 billion annually in the US alone (1).

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References

  1. Penberthy LT, Towne AR, Garnett LK, Perlin JB, DeLorenzo RJ. Estimating the economic burden of status epilepticus to the health care system. Seizure 2005;14:46–51.

    Article  PubMed  CAS  Google Scholar 

  2. Scholtes FB, Renier WO, Meinardi H. Generalized convulsive status epilepticus: causes, therapy and outcome in 346 patients. Epilepsia 1994;35:1104–1112.

    Article  PubMed  CAS  Google Scholar 

  3. Shorvon SD. Status Epilepticus: Its Clinical Features and Treatment in Children and Adults. New York: Cambridge University Press; 1994.

    Google Scholar 

  4. Turner WA. Epilepsy: A Study of Idiopathic Condition. London: Macmillan; 1907.

    Google Scholar 

  5. Lennox W. Epilepsy and Related Disorders. Boston: Little, Brown; 1960.

    Google Scholar 

  6. Oxbury JM, Whitty CW. Causes and consequences of status epilepticus in adults. A study of 86 cases. Brain 1971;94:733–744.

    Article  PubMed  CAS  Google Scholar 

  7. Rowan AJ, Scott DF. Major status epilepticus: a series of 42 patients. Acta Neurol Scand 1970;46:573–584.

    PubMed  CAS  Google Scholar 

  8. Pilke A, Partinnen M, Kovanen J. Status epilepticus and alcohol abuse: an analysis of 82 status epilepticus admissions. Acta Neurol Scand 1984;70:443–450.

    Article  PubMed  CAS  Google Scholar 

  9. Goulon M, Levy-Alcover MA, Nouailhat F. Status epilepticus in the adult. Epidemiologic and clinical study in an intensive care unit. Rev Electroencephalogr Neurophysiol Clin 1985;14:277–285.

    Article  PubMed  CAS  Google Scholar 

  10. Hunter RA. Status epilepticus: history, incidence and problems. Epilepsia 1959/60;1:162–188.

    PubMed  CAS  Google Scholar 

  11. Celesia GG, Messert B, Murphy MJ. Status epilepticus of late adult onset. Neurology 1972;22:1047–1055.

    PubMed  CAS  Google Scholar 

  12. Janz D. Conditions and causes of status epilepticus. Epilepsia 1961;3:170–177.

    Google Scholar 

  13. Heintel H, Kunkel H. Cerebrospinal fluid in status epilepticus. Results of a multifactorial analysis. Z Neurol 1972;201:261–268.

    Article  PubMed  CAS  Google Scholar 

  14. Aicardi J, Chevrié JJ. Convulsive status epilepticus in infants and children. A study of 239 cases. Epilepsia 1970;11:187–197.

    PubMed  CAS  Google Scholar 

  15. Yager JY, Cheang M, Seshia SS. Status epilepticus in child. Can J Neurol Sci 1988;15:402–405.

    PubMed  CAS  Google Scholar 

  16. Hauser WA. Status epilepticus: epidemiologic considerations. Neurology 1990;40(suppl 2):9–13.

    PubMed  CAS  Google Scholar 

  17. Clark LP, Prout TP. Status epilepticus: a clinical and pathological study in epilepsy (an article in three parts). Am J Insanity 1903–1904;60:291–306, 60:645–675, 60:81–108.

    Google Scholar 

  18. Bourneville DM. L’état de mal épileptique. In: Researches cliniques et therapeutiques sur l’%epilepsie et l’hysterie. Compte-rendu des observations recueillies à la Salpetrière. Paris: Delahaye 1876.

    Google Scholar 

  19. Dodson WE, DeLorenzo RJ, Tedley TA, Shinnar S, Treiman DM, Wannamaker BB. The treatment of convulsive status epilepticus; recommendations of the Epilepsy Foundation of America’s Working Group on Status Epilepticus. JAMA 1993;270:854–859.

    Article  Google Scholar 

  20. Gastaut H, Broughton R. Epileptic seizures: clinical and electrographic features, diagnosis and treatment. Springfield, IL: Charles C. Thomas; 1972:25–90.

    Google Scholar 

  21. Kramer R, Levisohn P. The duration of secondarily generalized tonic-clonic seizures. Epilepsia 1992;33(suppl 3):68(abstract).

    Google Scholar 

  22. Theodore WH, Porter RJ, Albert P, Kelley MA, Bromfield E, Devinsky O, Sato S. The secondarily generalized tonic-clonic seizure: a videotape analysis. Neurology 1994;44:1403–1407.

    PubMed  CAS  Google Scholar 

  23. Bleck TP. Convulsive disorders: status epilepticus. Clin Neuropharm 1991;14:191–198.

    CAS  Google Scholar 

  24. Treiman DM, Meyers PD, Walton NY, Collins JF, Colling C, Rowan J, Handforth A, Faught E, Calabrese VP, Uthman BM, Ramsay RE, Mamdani MB. A comparison of four treatments for generalized convulsive status epilepticus. New Engl J Med 1998;229:292–298.

    Google Scholar 

  25. Lowenstein DH, Bleck T, Macdonald RL. It’s time to revise the definition of status epilepticus. Epilepsia 1999;40:120–122.

    Article  PubMed  CAS  Google Scholar 

  26. DeLorenzo RJ, Pellock JM, Towne AR, Boggs JG. Epidemiology of status epilepticus. J Clin Neurophysiol 1995;12:316–325.

    PubMed  CAS  Google Scholar 

  27. Hesdorffer DC, Logroscino G, Cascino G, Annegers JF, Hauser WA. Incidence of status epilepticus in Rochester, Minnesota, 1965-1984. Neurology 1998;50:735–740.

    PubMed  CAS  Google Scholar 

  28. Wu YW, Shek DW, Garcia PA, Zhao S, Johnston SC. Incidence and mortality of generalized convulsive status epilepticus in California. Neurology 2002;58:1070–1076.

    PubMed  CAS  Google Scholar 

  29. Vignatelli L, Tonon C, D’Alessandro R. Incidence and short-term prognosis of status epilepticus in adults in Bologna, Italy. Epilepsia 2003;44:964–968.

    Article  PubMed  Google Scholar 

  30. Kanke S, Rosenow F, Vescovi M, Oertel WH, Mueller H-H, Wirbatz A, Katsarou N, Hamer H. Incidence of status epilepticus in adults in Germany: a prospective, population-based study. Epilepsia 2001;42:714–718.

    Article  Google Scholar 

  31. Coeytaux A, Jallon P, Galobardes B, Morabia A. Incidence of status epilepticus in French-speaking Switzerland. Neurology 2000;55:693–697.

    PubMed  CAS  Google Scholar 

  32. Mbodj I, Ndiaye M, Sene F, Salif Sow P, Sow HD, Diagana M, Pierre Ndiaye I, Gallo Diop A. Treatment of status epilepticus in a developing country. Neurophysiol Clin 2000;30:165–169.

    Article  PubMed  CAS  Google Scholar 

  33. Ogunniyi A, Ogunniyi JO, Bademosi O, Osuntokun BO, Adeuja AO. Aetiology of status epilepticus in Ibadan: a neuropathologic study. West Afr J Med 1992;11:263–267.

    PubMed  CAS  Google Scholar 

  34. Sridharan R, Radhakrishnan K, Ashok PP, Mousa ME. Epidemiological and clinical study of epilepsy in Benghazi, Libya. Epilepsia 1986;27:60–65.

    PubMed  CAS  Google Scholar 

  35. Tabarki B, Yacoub M, Selmi H, Oubich F, Barsaoui S, Essoussi AS. Infantile status epilepticus in Tunisia. Clinical, etiological, and prognostic aspects. Seizure 2001;10:365–369.

    Article  PubMed  CAS  Google Scholar 

  36. Kamgno J, Pion SD, Soussinesq M. Demographic impact of epilepsy in Africa: Results of a 10-year cohort study in a rural area of Cameroon. Epilepsia 2003;44:956–963.

    Article  PubMed  Google Scholar 

  37. Snow RW, Williams RE, Rogers JE, Mung’ala VO, Peshu N. The prevalence of epilepsy among a rural Kenyan population. Its association with premature mortality. Top Geogr Med 1994;46:175–179.

    CAS  Google Scholar 

  38. Tekle-Haimanot R, Forsgren L, Abebe M, Gebre-Mariam A, Heijebel J, Holmgren G, Ekstedt J. Clinical and electroencephalographic characteristics of epilepsy in rural Ethiopia: a communitybased study. Epilepsy Res 1990;7:230–239.

    Article  PubMed  CAS  Google Scholar 

  39. DeLorenzo RJ, Hauser WA, Towne AR, Boggs JG, Pellock JM, Penberthy L, Garnett L, Fortner CA, Ko D. A prospective, population-based epidemiologic study of status epilepticus in Richmond, Virginia. Neurology 1996;46:1029–1035.

    PubMed  CAS  Google Scholar 

  40. Logroscino G, Hesdorffer DC, Cascino G, Annegers JF, Hauser WA. Short-term mortality after a first episode of status epilepticus. Epilepsia 1997;38:1344–1349.

    Article  PubMed  CAS  Google Scholar 

  41. Delanty N, French JA, Labar DR, Pedley TA, Rowan AJ. Status epilepticus arising de novo in hospitalized patients: an analysis of 41 patients. Seizure 2001;10:116–119.

    Article  PubMed  CAS  Google Scholar 

  42. Logroscino G, Hesdorffer DC, Cascino G, Annegers JF, Hauser WA. Time trends in incidence, mortality, and case-fatality after first episode of status epilepticus. Epilepsia 2001;42:1031–1035.

    Article  PubMed  CAS  Google Scholar 

  43. Lowenstein DH, Alldredge BK. Status epilepticus at an urban public hospital in the 1980s. Neurology. 1993;43(3 Pt 1):483–498.

    PubMed  CAS  Google Scholar 

  44. Richmond Metropolitan Area Status Epilepticus Database, age distribution for 2,025 patients, unpublished data, 2003.

    Google Scholar 

  45. Towne AR, Pellock JM, Ko D, DeLorenzo RJ. Determinants of mortality in status epilepticus. Epilepsia 1994;35:27–34.

    Article  PubMed  CAS  Google Scholar 

  46. Velio SK, Ozmeno M, Boz C, Alio Z. Status epilepticus after stroke. Stroke 2001;32:169–172.

    Google Scholar 

  47. Labovitz SL, Hauser WA, Sacco RL. Prevelance and predictors of early seizure and status epilepticus after first stroke. Neurology 2001;57:200–206.

    PubMed  CAS  Google Scholar 

  48. Aminoff MJ, Simon RP. Status epilepticus, clinical features and consequences in 98 patients. Am J Med 1980;69:657–666.

    Article  PubMed  CAS  Google Scholar 

  49. DeLorenzo RJ, Garnett LK, Towne AR, Waterhouse EJ, Boggs JG, Morton LD, Choudhry MA, Barnes T, Ko D. Comparison of status epilepticus with prolonged seizure episodes lasting from 10–29 minutes. Epilepsia 1999;40:164–169.

    Article  PubMed  CAS  Google Scholar 

  50. Waterhouse EJ, Garnett LK, Towne AR, Morton LD, Barnes T, Ko D, DeLorenzo RJ. Prospective population-based study of intermittent and continuous convulsive status epilepticus in Richmond, Virginia. Epilepsia 1999;40:752–758.

    Article  PubMed  CAS  Google Scholar 

  51. Hauser WA. Status epilepticus: frequency, etiology, and neurological sequela. In: Delgado-Escueta AV, Wasterlain CG, Treiman DT, Porter RJ, eds. Status Epilepticus: Mechanisms of Brain Damage and Treatment. New York: Raven Press; 1983:3–14.

    Google Scholar 

  52. Leppik IE. Status epilepticus. Clin Ther 1985;7:272–278.

    PubMed  CAS  Google Scholar 

  53. Leppik IE. Status epilepticus. Neurol Clin 1986;4:633–643.

    PubMed  CAS  Google Scholar 

  54. Waterhouse EJ, Vaughan JK, Barnes TY, Boggs JG, Towne AR, Kopec-Garnett L, DeLorenzo RJ. Synergistic effect of status epilepticus and ischemic brain injury on mortality. Epilepsy Res 1998;29:175–183.

    Article  PubMed  CAS  Google Scholar 

  55. Shinnar S, Maytal J, Krasnoff L, Moshe SL. Recurrent status epilepticus in children. Ann Neurol 1992;31:598–602.

    Article  PubMed  CAS  Google Scholar 

  56. Waterhouse EJ, Garnett LK, Towne AR, Morton LD, Brown A, Ko D, DeLorenzo RJ. Risk factors for refractory status epilepticus. Epilepsia 1999;40(suppl. 7):151(abstract).

    Google Scholar 

  57. Jagoda A, Riggio S. Refractory status epilepticus in adults. Ann Emerg Med 1993;22:1337–1348.

    Article  PubMed  CAS  Google Scholar 

  58. Bleck TP. Advances in the management of refractory status epilepticus. Crit Care Med 1993;21:955–957.

    Article  PubMed  CAS  Google Scholar 

  59. Mayer SA, Claassen J, Lokin J, Mendelsohn F, Dennis LJ, Fitzsimmons B-F. Refractory status epilepticus: frequency, risk factors, and impact on outcome. Arch Neurol 2002;59:205–210.

    Article  PubMed  Google Scholar 

  60. Treiman DM, Walton NY, Collins JF, Point P. Treatment of status epilepticus if first drug fails. Epilepsia 1999;40(suppl 7):243(abstract).

    Google Scholar 

  61. Claassen J, Hirsch LJ, Emerson RG, Mayer SA. Treatment of refractory status epilepticus with pentobarbital, propofol, or midazolam: a systematic review. Epilepsia 2002;43:146–153.

    Article  PubMed  CAS  Google Scholar 

  62. Sahin M, Menache CC, Holmes GL, Riviello JJ. Outcome of severe refractory status epilepticus in children. Epilepsia 2001;42:1461–1467.

    Article  PubMed  CAS  Google Scholar 

  63. Gilbert DL, Gartside PS, Glauser TA. Efficacy and mortality in treatment of refractory generalized convulsive status epilepticus in children: a meta-analysis. J Child Neurol. 1999;14:602–609.

    PubMed  CAS  Google Scholar 

  64. Kim SJ, Lee DY, Kim JS. Neurologic outcomes of pediatric epileptic patients with pentobarbital coma. Pediatr Neurol 2001;25:217–220.

    Article  PubMed  CAS  Google Scholar 

  65. Sahin M, Menache CC, Holmes GL, Riviello JJ. Prolonged treatment for acute symptomatic refractory status epilepticus. Neurology 2003;61:395–401.

    Google Scholar 

  66. Shinnar S, Pellock JM, Moshe SL, Maytal J, O’Dell C, Driscoll SM, Alemany M, Newstein, DeLorenzo RJ. In whom does status epilepticus occur: age-related differences in children. Epilepsia 1997;38:907–914.

    Article  PubMed  CAS  Google Scholar 

  67. Gross-Tsur V, Shinnar SH. Convulsive status epilepticus in children. Harefuah 1993;125:93–95.

    PubMed  CAS  Google Scholar 

  68. Sillanpaa M, Shinnar S. Status epilepticus in a population-based cohort with childhood-onset epilepsy in Finland. Ann Neurol 2002;52:303–310.

    Article  PubMed  Google Scholar 

  69. Maytal J, Shninnar S, Moshe SL, Alvarez LA. Low morbidity and mortality of status epilepticus in children. Pediatrics 1989;83:323–331.

    PubMed  CAS  Google Scholar 

  70. Shinnar S, Pellock JM, Berg AT, O’Dell C, Driscoll SM, Maytal J, Moshe SL, DeLorenzo RJ. Shortterm outcomes of children with febrile status epilepticus. Epilepsia 2001;42:47–53.

    Article  PubMed  CAS  Google Scholar 

  71. Lacroix J, Deal C, Gauthier M, Rousseau E, Farrell CA. Admissions to a pediatric internsive care unit for status epilepticus: a 10-year experience. Crit Care Med 1994;22:827–832.

    Article  PubMed  CAS  Google Scholar 

  72. Eriksson KJ, Koivikko MJ. Status epilepticus in children: a etiology, treatment, and outcome. Dev Med Child Neurol 1997;39:652–658.

    Article  PubMed  CAS  Google Scholar 

  73. Annegers JF, Hauser WA, Shirts SB, Kurland LT. Factors prognostic of unprovoked seizures after febrile convulsions. N Engl J Med 1987;316:493–498.

    Article  PubMed  CAS  Google Scholar 

  74. Nelson KB, Ellenburg JH. Prognosis in children with febrile seizures. Pediatrics 1978;61:720–727.

    PubMed  CAS  Google Scholar 

  75. Nelson KB, Ellenburg JH. Predictors of epilepsy in children who have experienced febrile seizures. N Engl J Med 1976;295:1029–1033.

    Article  PubMed  CAS  Google Scholar 

  76. Berg AT, Shinnar S, Hauser WA, Alemany M, Shapiro ED, Salomon ME, Crain EF. A prospective study of recurrent febrile seizures. N Engl J Med 1992;327:1122–1127.

    Article  PubMed  CAS  Google Scholar 

  77. Berg AT, Shinnar S, Darefsky AS, Holford TR, Shapiro ED, Salomon NE, Crain EF, Hayser AWl. Predictors of recurrent febrile seizures. Arch Pediatr Adolesc Med 1997;151:371–378.

    PubMed  CAS  Google Scholar 

  78. Ellenburg JH, Nelson KB. Febrile seizures and later intellectual performance. Arch Neurol 1978;35:17–21.

    Google Scholar 

  79. Berg AT, Shinnar S. Complex febrile seizures. Epilepsia 1996;37:126–133.

    Article  PubMed  CAS  Google Scholar 

  80. Corey LA, Berg K, Pellock JM, Solaas MH, Nance WE, DeLorenzo RJ. The occurrence of epilepsy and febrile seizures in Virginia and Norwegian twins. Neurology 1991;41:1433–1436.

    PubMed  CAS  Google Scholar 

  81. Miller LL, Pellock JM, DeLorenzo RJ, Meyer JM, Corey LA. Univariate genetic analyses of epilepsy and seizures in a population-based twin study: The Virginia Registry. Genetic Epidemiol 1998;15:33–49.

    Article  CAS  Google Scholar 

  82. Miller LL, Pellock JM, Boggs JG, DeLorenzo RJ, Meyer JM, Corey LA. Epilepsy and seizure occurrence in a population-based sample of Virginian twins and their families. Epilepsy Res 1999;34:135–143.

    Article  PubMed  CAS  Google Scholar 

  83. Corey LA, Pellock JM, Boggs JG, Miller LL, DeLorenzo RJ. Evidence for a genetic predisposition for status epilepticus. Neurology 1998;50:558–560.

    PubMed  CAS  Google Scholar 

  84. DeLorenzo RJ. Clinical and epidemiological study of status epilepticus in the elderly. In: Rowan AJ, Ramsey RE, eds. Seizures and Epilepsy in the Elderly. Newton, MA: Butterworth-Heinemann; 1997;191–205.

    Google Scholar 

  85. Waterhouse EJ, DeLorenzo RJ. Status epilepticus in older patients: epidemiology and treatment options. Drugs & Aging 2001;18:133–142.

    Article  CAS  Google Scholar 

  86. Sung CY, Chu NS. Status epilepticus in the elderly: etiology, seizure type and outcome. Acta Neurol Scand 1989;80:51–56.

    PubMed  CAS  Google Scholar 

  87. Labar D, Barrera J, Solomon G, Harden C. Nonconvulsive status epilepticus in the elderly: a case series and review of the literature. J Epilepsy 1998;11:74–78.

    Article  Google Scholar 

  88. Litt B, Wityk RJ, Hertz SH, Mullen PD, Weiss H, Ryan DH, Henry TR. Nonconvulsive status epilepticus in the critically ill elderly. Epilepsia 1998;39:1194–1202.

    Article  PubMed  CAS  Google Scholar 

  89. Walker MC. Status epilepticus on the intensive care unit. J Neurol 2003;250:401–406.

    Article  PubMed  Google Scholar 

  90. Towne AR, Waterhouse EJ, Boggs JG, Garnett LK, Brown AJ, Smith JR, DeLorenzo RJ. Prevalence of nonconvulsive status epilepticus in comatose patients. Neurology 2000;54:340–345.

    PubMed  CAS  Google Scholar 

  91. Drislane FW, Schomer DL. Clinical implications of generalized electrographic status epilepticus. Epilepsy Res 1994;19:111–121.

    Article  PubMed  CAS  Google Scholar 

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Waterhouse, E.J. (2005). Epidemiology of Status Epilepticus. In: Drislane, F.W. (eds) Status Epilepticus. Current Clinical Neurology. Humana Press. https://doi.org/10.1385/1-59259-945-1:055

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  • DOI: https://doi.org/10.1385/1-59259-945-1:055

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