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Pilot and Preliminary Studies of Thrombolytic Therapy for Stroke

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Thrombolytic Therapy for Acute Stroke

Part of the book series: Current Clinical Neurology ((CCNEU))

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Abstract

The demonstration that tissue plasminogen activator (t-PA) is clinically effective for acute ischemic stroke was based on many important studies over the past two decades that then led to groundbreaking preliminary clinical trials. This chapter highlights and discusses these studies and their historical significance. Thrombolytic therapy is an inherently attractive treatment for ischemic stroke based on the known pathological and angiographic substrates of ischemic cerebrovascular disease (see Chapters 1–3). The majority of acute ischemic strokes are the direct consequences of atherothrombosis or thromboembolism of a cerebral or precerebral artery (see Chapter 2). The critical event is usually the formation of an acute thrombus, so the rationale for thrombolytic treatment is to achieve arterial recanalization with a relatively safe agent soon enough to improve patient outcome.

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Author information

Authors and Affiliations

  1. Stroke Program, Department of Neurology, The Mount Sinai School of Medicine and Medical Center, New York, NY

    Steven R. Levine MD

  2. Department of Neurology, University of Virginia Health System, Charlottesville, VA

    E. Clarke Haley MD

  3. UCSD Stroke Center, University of California, San Diego

    Patrick Lyden MD

  4. Veteran’s Affairs Medical Center, San Diego, CA

    Patrick Lyden MD

Authors
  1. Steven R. Levine MD
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  2. E. Clarke Haley MD
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  3. Patrick Lyden MD
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Editor information

Editors and Affiliations

  1. USCD Stroke Center, University of California, San Diego

    Patrick D. Lyden MD

  2. Veteran’s Affairs Medical Center, San Diego, CA

    Patrick D. Lyden MD

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© 2005 Humana Press Inc., Totowa, NJ

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Levine, S.R., Haley, E.C., Lyden, P. (2005). Pilot and Preliminary Studies of Thrombolytic Therapy for Stroke. In: Lyden, P.D. (eds) Thrombolytic Therapy for Acute Stroke. Current Clinical Neurology. Humana Press. https://doi.org/10.1385/1-59259-933-8:95

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  • DOI: https://doi.org/10.1385/1-59259-933-8:95

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-398-5

  • Online ISBN: 978-1-59259-933-2

  • eBook Packages: MedicineMedicine (R0)

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