Abstract
The US Food and Drug Administration (FDA) approved intravenous tissue plasminogen activator (t-PA) as treatment for acute ischemic stroke in June 1996, based on the results of the National Institute of Neurological Disorders and Stroke (NINDS) study (see Chapter 7). The next important question was whether t-PA treatment could be applied in nonstudy community medical centers with a feasibility, safety, and efficacy comparable to that of NINDS trial. This question was answered by many community studies, which evaluated t-PA therapy in acute ischemic stroke. This chapter discusses community experience with intravenous t-PA in stroke treatment from 1996 to the present. Those studies are discussed in chronological order, highlighting the outcome and complication rates of each. Table 1 summarizes the results.
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© 2005 Humana Press Inc., Totowa, NJ
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Al-Khoury, L., Jackson, C.M. (2005). Community Experience With Intravenous Thrombolysis for Acute Stroke. In: Lyden, P.D. (eds) Thrombolytic Therapy for Acute Stroke. Current Clinical Neurology. Humana Press. https://doi.org/10.1385/1-59259-933-8:149
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DOI: https://doi.org/10.1385/1-59259-933-8:149
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