Several clinical trials covering thousands of patient cohorts have clearly demonstrated the correlation between the long-term macrovascular and microvascular complications of diabetes and poorly controlled blood glucose with the subsequent benefits of tighter glycemic control. This data indicates that insulin use (even in the early stages of diabetes) to insure proper glycemic control can be invaluable in reducing mortality and morbidity. In fact, earlier insulin use reduces glucose toxicity, allows endogenous insulin to function more efficiently, and reduces strain on the deteriorating β-cell (1).


Human Insulin Insulin Glargine Insulin Analog Oral Agent Postprandial Glucose 
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© Humana Press Inc., Totowa, NJ 2005

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