Cystic Fibrosis

  • Eugene H. LewisIII
  • Myra J. Lewis
  • Jean A. Amos
  • Gregory J. Tsongalis

Abstract

Cystic fibrosis (CF), a clinically heterogeneous disease, is the first genetic disease for which adult population screening has been initiated in the United States. Since the discovery of the CFTR gene in 1989, much has been learned about the pathophysiology and molecular genetics of this disorder. This review includes an overview of the genetics of CF, a discussion of pathophysiology, and clinical and anatomic pathology and concludes with a review of molecular diagnostics.

Keywords

Const Ipation Vasculiti Pneumothorax Cholangitis Poss 

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Copyright information

© Humana Press, a part of Springer Science+Business Media, LLC 2006

Authors and Affiliations

  • Eugene H. LewisIII
    • 1
  • Myra J. Lewis
    • 1
  • Jean A. Amos
    • 2
  • Gregory J. Tsongalis
    • 3
  1. 1.Department of Pathology and Laboratory MedicineHartford HospitalHartfordUSA
  2. 2.Molecular GeneticsSpecialty Laboratorie, Inc.Santa Monica
  3. 3.Department of PathologyDartmouth Medical School, Dartmouth-Hitchcock Medical CenterLebanon

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