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Integrative Physiology in the Proteomics and Post-Genomics Age pp 215–237Cite as

The Zebrafish As an Integrative Physiology Model

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Abstract

The complexity of nervous system structure and function presents considerable challenges for understanding the output of the nervous system (behavior) in terms of the molecular and cellular properties of component parts (neurons). For integrated studies of nervous system physiology, a model system needs to meet several requirements. First, the model system should have a well-defined anatomy that ideally is simple and minimally complex. Furthermore, the ability to identify neurons of interest for physiological analysis and perturbation of known cellular processes augments the power of the system. Finally, the system should allow elimination of the unique functional contribution of specific neurons either by targeted ablation methods or genetic and molecular perturbations.

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  1. Department of Physiology and Biophysics, University of Colorado Health Sciences Center, Denver, CO

    Alicia E. Novak & Angeles B. Ribera

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  1. Alicia E. Novak
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  2. Angeles B. Ribera
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  1. Department of Physiology, University of Saskatchewan, Saskatoon, Canada

    Wolfgang Walz PhD

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Novak, A.E., Ribera, A.B. (2005). The Zebrafish As an Integrative Physiology Model. In: Walz, W. (eds) Integrative Physiology in the Proteomics and Post-Genomics Age. Humana Press. https://doi.org/10.1385/1-59259-925-7:215

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