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β-Lactam Antibiotics

  • Chapter
Drug Interactions in Infectious Diseases

Part of the book series: Infectious Disease ((ID))

Abstract

The β-lactam antibiotics are a large class of diverse compounds used clinically in both the oral and parenteral forms. The β-lactam antibiotic agents have become the most widely used therapeutic class of antimicrobials because of their broad antibacterial spectrum and excellent safety profile. Reports of drug-drug interactions with the β-lactam antimicrobials are a relatively rare phenomenon, and when interactions do occur, they are generally minor. This chapter describes the drug-drug interactions of the β-lactam antibiotics: penicillins, cephalosporins, carbapenems, and monobactams.

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References

  1. Rogers HJ, James CA, Morrison PJ. Effect of cimetidine on oral absorption of ampicillin and cotrimoxazole. J Antimicrob Chemother 1980;6:297–300.

    PubMed  CAS  Google Scholar 

  2. Paulsen O, Hoglund P, Walder M. No effect of omeprazole-induced hypoacidity on the bioavailability of ampicillin and bacampicillin. Scand J Infect Dis 1989;21:219–223.

    PubMed  CAS  Google Scholar 

  3. Stainforth DH, Clarke HL, Horton R, et al. Augmentin bioavailability following cimetidine, aluminum hydroxide and milk. Int J Clin Pharmacol Ther Toxicol 1985;23:154–157.

    Google Scholar 

  4. Deppermann KM, Lode H, Hoffken G, et al. Influence of ranitidine, pirenzepine, and aluminum magnesium hydroxide on the bioavailability of various antibiotics, including amoxicillin, cephalexin, doxycycline, and amoxicillin-clavulanic acid. Antimicrob Agents Chemother 1989;33:1901–1907.

    PubMed  CAS  Google Scholar 

  5. Sommers DK, Van Wyk M, Moncrieff J. Influence of food and reduced gastric acidity on the bioavailability of bacampicillin and cefuroxime axetil. Br J Clin Pharm 1984:18:535–539.

    CAS  Google Scholar 

  6. Jick H, Porter JB. Potentiation of ampicillin skin reactions by allopurinol or hyperuricemia. J Clin Pharmacol 1981;21:456–458.

    PubMed  CAS  Google Scholar 

  7. Fessel WJ. Immunologic reactivity in hyperuricemia. N Engl J Med 1972;286:1218.

    PubMed  CAS  Google Scholar 

  8. Townsend RS. In vitro inactivation of gentamicin by ampicillin. Am J Hosp Pharm 1989;46:2250–2251.

    PubMed  CAS  Google Scholar 

  9. McLaughlin JE, Reeves DS. Clinical and laboratory evidence for inactivation of gentamicin by carbenicillin. Lancet 1971;1:261–264.

    PubMed  CAS  Google Scholar 

  10. Uber WE, Brundage RC, White RL, et al. In vivo inactivation of tobramycin by piperacillin. DICP Ann Pharmacother 1991;25:357–359.

    CAS  Google Scholar 

  11. Halstenson CE, Hirata CA, Heim-Duthoy KL, et al. Effect of concomitant administration of piperacillin on the disposition of netilmicin and tobramycin in patients with end-stage renal disease. Antimicrob Agents Chemother 1990;34:128–133.

    PubMed  CAS  Google Scholar 

  12. Davies M, Morgan JR, Anand C. Interactions of carbenicillin and ticarcillin with gentamicin. Antimicrob Agents Chemother 1975;7:431–434.

    PubMed  CAS  Google Scholar 

  13. Weibert R, Keane W, Shapiro F. Carbenicillin inactivation of aminoglycosides in patients with severe renal failure. Trans Am Soc Artif Organs 1976;22:439.

    CAS  Google Scholar 

  14. Eykyn S, Philips I, Ridley M. Gentamicin plus carbenicillin. Lancet 1 1971;13:545,546.

    Google Scholar 

  15. Davies M, Morgan JR, Anand C. Interactions of carbenicillin and ticarcillin with gentamicin. Antimicrob Agents Chemother 1975:7:431–434.

    PubMed  CAS  Google Scholar 

  16. Kradjian WA, Burger R. In vivo inactivation of gentamicin by carbenicillin and ticarcillin. Arch Intern Med 1980;140:1668–1670.

    Google Scholar 

  17. Lau A, Lee M, Flascha S, et al. Effect of piperacillin on tobramycin pharmacokinetics in patients with normal renal function. Antimicrob Agents Chemother 1983;24:533–537.

    PubMed  CAS  Google Scholar 

  18. Hitt CM, Patel KB, Nicolau DP, Zhu Z, Nightingale CH. Influence of piperacillintazobactam on pharmacokinetics of gentamicin given once daily. Am J Health Syst Pharm 1997;1:2704–2708.

    Google Scholar 

  19. Dowell JA, Korth-Bradley J, Milisci M, et al. Evaluating possible pharmacokinetic interactions between tobramycin, piperacillin, and a combination of piperacillin and tazobactam in patients with various degrees of renal impairment. J Clin Pharmacol 2001;41:979–986.

    PubMed  CAS  Google Scholar 

  20. Noone P, Pattison JR. Therapeutic implications of interaction of gentamicin and penicillins. Lancet 1971;2:575–578.

    PubMed  CAS  Google Scholar 

  21. Ervin FR, Bullock WE, Nuttall CE. Inactivation of gentamicin by penicillins in patients with renal failure. Antimicrob Agents Chemother 1976;9:1009–1011.

    Google Scholar 

  22. Cheng SH, White A. Effect of orally administered neomycin on the absorption of penicillin V. N Engl J Med 1962;267:1296–1297.

    PubMed  CAS  Google Scholar 

  23. Moellering RC, Wennersten C, Weinberg AN. Synergy of penicillin and gentamicin against enterococci. J Infect Dis 1971;S124:207.

    Google Scholar 

  24. Guenthner SH, Chao HP, Wenzel RP. Synergy between amikacin and ticarcillin or mezlocillin against nosocomial bloodstream isolates. J Antimicrob Chemother 1986;18:550–552.

    PubMed  CAS  Google Scholar 

  25. Laverdiere M, Gallimore B, Restieri C, et al. In vitro synergism of ceftriaxone combined with aminoglycosides against Pseudomonas aeruginosa. Diagn Microbiol Infect Dis 1994;19:39–46.

    PubMed  CAS  Google Scholar 

  26. Marks MI, Hammerberg S, Greenstone G, et al. Activity of newer aminoglycosides and carbenicillin, alone, and in combination against gentamicin-resistant Pseudomonas aeruginosa. Antimicrob Agents Chemother 1976;10:399–401.

    PubMed  CAS  Google Scholar 

  27. Moellering RC, Wennersten, Weinberg AJ. Studies on antibiotic synergism against enterococci. I. Bacteriologic studies. J Lab Clin Med 1971;77:821–828.

    PubMed  CAS  Google Scholar 

  28. Weinstein AJ, Moellering RC. Penicillin and gentamicin therapy for enterococcal infections. JAMA 1973;223:1030–1032.

    PubMed  CAS  Google Scholar 

  29. Anderson ET, Young LS, Hewitt WL. Antimicrobial synergism in the therapy of Gramnegative rod bacteremia. Chemotherapy 1978;24:45–54.

    PubMed  CAS  Google Scholar 

  30. Brown CH, Natelson EA, Bradshaw MW, et al. The hemostatic defect produced by carbenicillin. N Engl J Med 1974;291:265–270.

    PubMed  CAS  Google Scholar 

  31. Brown CH, Natelson EA, Bradshaw MW, et al. Study of the effects of ticarcillin on blood coagulation and platelet function. Antimicrob Agents Chemother 1975;7:652–657.

    PubMed  CAS  Google Scholar 

  32. Brown CH, Bradshaw MW, Natelson EA, et al. Defective platelet function following the administration of penicillin compounds. Blood 1976;6:949–956.

    Google Scholar 

  33. Andrassy K, Ritz E, Hasper B, et al. Penicillin-induced coagulation disorder. Lancet 1976;2:1039–1041.

    PubMed  CAS  Google Scholar 

  34. Andrassy K, Weischedel E, Ritz E, et al. Bleeding in uremic patients after carbenicillin. Thrombos Haemost 1976;36:115–126.

    CAS  Google Scholar 

  35. Tabernero Romo JM, Corbacho L, Sanchez S, et al. Effects of carbenicillin on blood coagulation; a study in patients with chronic renal failure. Clin Nephrol 1979;11:31–34.

    Google Scholar 

  36. Wisloff F, Larsen JP, Dahle A, et al. Effect of prophylactic high-dose treatment with ampicillin and cloxacillin on bleeding time and bleeding in patients undergoing elective vascular surgery. Scand J Haematol 1983;31:97–101.

    PubMed  CAS  Google Scholar 

  37. Lurie A, Ogilvie M, Gold CH, et al. Carbenicillin-induced coagulopathy. S Afr Med J 1974;48:457–461.

    PubMed  CAS  Google Scholar 

  38. Taylor AT, Pritchard DC, Goldstein AO, et al. Continuation of warfarin-nafcillin interaction during dicloxacillin therapy. J Fam Pract 1994;39:182–185.

    PubMed  CAS  Google Scholar 

  39. Heilker GM, Fowler JW, Self TH, et al. Possible nafcillin-warfarin interaction. Arch Intern Med 1994;154:822–824.

    PubMed  CAS  Google Scholar 

  40. Qureshi GD, Reinders TP, Somori GJ, et al. Warfarin resistance with nafcillin therapy. Ann Intern Med 1984;100:527–529.

    PubMed  CAS  Google Scholar 

  41. Shovick VA, Rihn TL. Decreased hypoprothrombinemic response to warfarin secondary to the warfarin-nafcillin interaction. Drug Intell Clin Pharm 1991;25:598–600.

    CAS  Google Scholar 

  42. Krstenansky PM, Jones WN, Garewal HS. Effect of dicloxacillin sodium on the hypoprothrombinemic response to warfarin sodium. Clin Pharm 1987;6:804–806.

    PubMed  CAS  Google Scholar 

  43. Mailloux AT, Gidal BE, Sorkness CA. Potential interaction between warfarin and dicloxacillin. Ann Pharmacother 1996:30:1402–1407.

    PubMed  CAS  Google Scholar 

  44. Davis RL, Berman W, Wernly JA, et al. Warfarin-nafcillin interaction. J Pediatr 1991;118:300–303.

    PubMed  CAS  Google Scholar 

  45. Rolinson GN, Sutherland R. The binding of antibiotics to serum proteins. Br J Pharmacol 1965;25:638–650.

    CAS  Google Scholar 

  46. Brown MA, Korchinski ED, Miller DR. Interaction of penicillin-G and warfarin? Can J Hosp Pharm 1979;32:18,19.

    Google Scholar 

  47. Davydov L, Yermolnik M, Cuni LJ. Warfarin and amoxicillin/clavulanate drug interaction. Ann Pharmacother 2003;37:367–370.

    PubMed  Google Scholar 

  48. Kampmann J, Molholm Hansen J, Siersbaek-Nielsen K, Laursen H. Effect of some drugs on penicillin half-life in blood. Clin Pharmacol Ther 1972;13:516–519.

    PubMed  CAS  Google Scholar 

  49. Kunin CM. Clinical pharmacology of the new penicillins. II. Effect of drugs which interfere with binding to serum proteins. Clin Pharmacol Ther 1966;7:180–188.

    PubMed  CAS  Google Scholar 

  50. Suffness M, Rose BS. Potential drug interactions and adverse effects related to aspirin. Drug Intell Clin Pharm 1974;8:694–699.

    CAS  Google Scholar 

  51. Moskowitz B, Somani SM, McDonald RH. Salicylate interaction with penicillin and secobarbital binding sites on human serum albumin. Clin Toxicol 1973;6:247–256.

    PubMed  CAS  Google Scholar 

  52. Hayes AH. Therapeutic implications of drug interactions with acetaminophen and aspirin. Arch Intern Med 1981:141:301–304.

    PubMed  CAS  Google Scholar 

  53. Schafer-Korting M, Kirch W, Axthelm T, et al. Atenolol interaction with aspirin, allopurinol, and ampicillin. Clin Pharmacol Ther 1983;33:283–288.

    PubMed  CAS  Google Scholar 

  54. McLean AJ, Tonkin A, McCarthy P, et al. Dose-dependence of atenolol-ampicillin interaction. Br J Clin Pharmacol 1984;18:969–971.

    PubMed  CAS  Google Scholar 

  55. Westphal JF, Trouvin JH, Deslandes A, et al. Nifedipine enhances amoxicillin absorption kinetics and bioavailability in humans. J Pharmacol Exp Ther 1990;255:312–317.

    PubMed  CAS  Google Scholar 

  56. Lang CC, Jamal SK, Mohamed Z, et al. Evidence of an interaction between nifedipine and nafcillin in humans. Br J Clin Pharmacol 2003;55:588–590.

    PubMed  CAS  Google Scholar 

  57. Jawetz E. Gunnison JB, Coleman VR. The combined action of penicillin with streptomycin or chloromycetin on enterococci in vitro. Science 1950;3:254–256.

    Google Scholar 

  58. Wallace JF, Smith H, Garcia M, et al. Studies on the pathogenesis of meningitis. VI Antagonism between penicillin and chloramphenicol in experimental pneumococcal meningitis. J Lab Clin Med 1967;70:408–418.

    PubMed  CAS  Google Scholar 

  59. Yourassowsky E, Monsieur R. Antagonism limit of penicillin G and chloramphenicol against Neisseria meningitidis. Arzneimittel Forsch 1971;21:1385–1387.

    CAS  Google Scholar 

  60. Gjessing HC, Odegaard K. Oral chloramphenicol alone and with intramuscular procaine penicillin in the treatment of gonorrhoea. Br J Vener Dis 1967;43:133–136.

    PubMed  CAS  Google Scholar 

  61. DeRitis F, Giammanco G, Manzillo G. Chloramphenicol combined with ampicillin in treatment of typhoid. Br Med J 1972;4:17,18.

    CAS  Google Scholar 

  62. Ali HM. Reduced ampicillin bioavailability following oral coadministration with chloroquine. J Antimicrob Chemother 1985;15:781–784.

    PubMed  CAS  Google Scholar 

  63. Barriere SL, Catlin DH, Orlando PL, et al. Alteration in the pharmacokinetic disposition of ciprofloxacin by simultaneous administration of azlocillin. Antimicrob Agents Chemother 1990;34:823–826.

    PubMed  CAS  Google Scholar 

  64. Peterson LR, Moody JA, Fasching CE, et al. In vivo and in vitro activity of ciprofloxacin plus azlocillin against 12 streptococcal isolates in a neutropenic site model. Diagn Microbiol Infect Dis 1987;7:127–136.

    PubMed  CAS  Google Scholar 

  65. Dossetor J. Drug interaction with oral contraceptive steroids [editorial]. Br Med J 1980;280:467,468.

    Google Scholar 

  66. DeSano EA, Hurley SC. Possible interaction of antihistamines and antibiotics with oral contraceptive effectiveness. Fertil Steril 1982;1:853,854.

    Google Scholar 

  67. Bainton R. Interaction between antibiotic therapy and contraceptive medication. Oral Surg Oral Med Oral Pathol 1986;61:453–455.

    PubMed  CAS  Google Scholar 

  68. Silber TJ. Apparent oral contraceptive failure associated with antibiotic administration. J Adolesc Health Care 1983;4:287–289.

    PubMed  CAS  Google Scholar 

  69. Miller DM, Helms SE, Brodell RT. A practical approach to antibiotic treatment in women taking oral contraceptives. J Am Acad Dermatol 1994;30:1008–1011.

    PubMed  CAS  Google Scholar 

  70. Fernandez N, Sierra M, Diez MJ, et al. Study of the pharmacokinetic interaction between ethinylestradiol and amoxicillin in rabbits. Contraception 1997:55:47–52.

    PubMed  CAS  Google Scholar 

  71. Back DJ, Brenckenridge AM, Cross KJ, et al. An antibiotic interaction with ethinyloestradiol in the rat and rabbit. J Steroid Biochem 1982;16:407–413.

    PubMed  CAS  Google Scholar 

  72. Back DJ, Breckenridge AM, MacIver M, et al. The effects of ampicillin on oral contraceptive steroids in women. Br J Clin Pharmacol 1982;14:43–48.

    PubMed  CAS  Google Scholar 

  73. Friedman CI, Huneke AL, Kim MH, et al. The effect of ampicillin on oral contraceptive effectiveness. Obstet Gynecol 1980;55:33–37.

    PubMed  CAS  Google Scholar 

  74. Joshi JV, Joshi UM, Sankholi GM, et al. A study of interaction of low-dose combination oral contraceptive with ampicillin and metronidazole. Contraception 1980;22:643–652.

    PubMed  CAS  Google Scholar 

  75. Weisberg E. Interactions between oral contraceptives and antifungals/antibacterials. Is contraceptive failure the result? Clin Pharmacokinet 1999;36:309–13.

    PubMed  CAS  Google Scholar 

  76. Veremis SA, Maddux MS, Pollak R, et al. Subtherapeutic cyclosporine concentrations during nafcillin therapy. Transplantation 1987;43:913–915.

    PubMed  CAS  Google Scholar 

  77. Finland M, Bach MC, Garner C, et al. Synergistic action of ampicillin and erythromycin against Nocardia asteroids: effect of time of incubation. Antimicrob Agents Chemother 1974;5:344–353.

    PubMed  CAS  Google Scholar 

  78. Roberts CE, Rosenfeld LS, Kirby WM. Synergism of erythromycin and penicillin against resistant staphylococci: mechanism and relation to synthetic penicillins. Antimicrob Agents Chemother 1962:831–842.

    Google Scholar 

  79. Waterworth PM. Apparent synergy between penicillin and erythromycin or fusidic acid. Clin Med 1963:70:941–953.

    PubMed  CAS  Google Scholar 

  80. Oswald EJ, Reedy RJ, Wright WW. Antibiotic combinations: an in vitro study of antistaphylococcal effects of erythromycin plus penicillin, streptomycin, or tetracycline. Antimicrob Agents Chemother 1961:904–910.

    Google Scholar 

  81. Herrell WE, Balows A, Becker J. Erythrocillin: a new approach to the problem of antibiotic-resistant staphylococci. Antibiot Med Clin Ther 1960;7:637–642.

    CAS  Google Scholar 

  82. Manten A. Synergism and antagonism between antibiotic mixtures containing erythromycin. Antibiot Chemother 1954;4:1228–1233.

    CAS  Google Scholar 

  83. Allen NE, Epp JK. Mechanism of penicillin-erythromycin synergy on antibiotic resistant Staphylococcus aureus. Antimicrob Agents Chemother 1978;13:849–853.

    PubMed  CAS  Google Scholar 

  84. Manten A, Terra JI. The antagonism between penicillin and other antibiotics in relation to drug concentration. Chemotherapia 1964;8:21–29.

    Google Scholar 

  85. Chang TW, Weinstein L. Inhibitory effects of other antibiotics on bacterial morphologic changes induced by penicillin G. Nature 1966:211:763–765.

    PubMed  CAS  Google Scholar 

  86. Garrod LP, Waterworth PM. Methods of testing combined antibiotic bactericidal action and the significance of the results. J Clin Pathol 1962;15:328–338.

    PubMed  CAS  Google Scholar 

  87. Strom J. Penicillin and erythromycin singly and in combination in scarlatina therapy and the interference between them. Antibiot Chemother 1961;11:694–697.

    PubMed  CAS  Google Scholar 

  88. Robinson L, Fonseca K. Value of the minimum bactericidal concentration of antibiotics in the management of a case of recurrent Streptococcus bovis septicaemia. J Clin Pathol 1982;35:879,880.

    PubMed  CAS  Google Scholar 

  89. Bach MC, Monaco AP, Finland M. Pulmonary nocardiosis therapy with minocycline and with erythromycin plus ampicillin. JAMA 1973;224:1378–1381.

    PubMed  CAS  Google Scholar 

  90. Martinez JA, Horcajada JP, Almela M, et al. Addition of a macrolide to a β-lactam-based empirical antibiotic regimen is associated with lower in-hospital mortality for patients with bacteremic pneumococcal pneumonia. Clin Infect Dis 2003;36:389–395.

    PubMed  CAS  Google Scholar 

  91. Waterer GW, Somes GW, Wunderink RG. Monotherapy may be suboptimal for severe bacteremic pneumococcal pneumonia. Arch Intern Med 2001;161:1837–1842.

    PubMed  CAS  Google Scholar 

  92. Mutson MA, Stanek. Bacteremic pneumococcal pneumonia in one American city: a 20-year longitudinal study, 1978–1997. Am J Med 1999;107:S34–S43.

    Google Scholar 

  93. Mandell LA, Bartlett JG, Dowell SF, et al. Update of practice guidelines for the management of community-acquired pneumonia in immunocompetent adults. Clin Infect Dis 2003;37:1405–1433.

    PubMed  Google Scholar 

  94. Huupponen R, Seppala P, Iisalo E. Effect of guar gum, a fibre preparation on digoxin and penicillin absorption in man. Eur J Clin Pharmacol 1984;26:279–281.

    PubMed  CAS  Google Scholar 

  95. Brooks BM, Thomas AL, Coleman JW. Benzylpenicillin differentially conjugates to IFN-γ, TNF-α, IL-1β, IL-4 and IL-13 but selectively reduces IFN-γ activity. Clin Exp Immunol 2 2003;131:268–274.

    CAS  Google Scholar 

  96. Brooks BM, Thomas AL, Coleman JW. Benzylpenicillin differentially conjugates to IFN-γ, TNF-α, IL-1β, IL-4 and IL-13 but selectively reduces IFN-γ activity. Clin Exp Immunol 2003;131:268–274.

    PubMed  CAS  Google Scholar 

  97. Attef OA, Ali AA. Effect of khat chewing on the bioavailability of ampicillin and amoxycillin. J Antimicrob Chemother 1997;39:523–525.

    PubMed  CAS  Google Scholar 

  98. Jayasagar G, Krishna Kumar M, Chandrasekhar K, et al. Effect of cephalexin on the pharmacokinetics of metformin in healthy human volunteers. Drug Metabol Drug Interact 2002;19:41–48.

    PubMed  CAS  Google Scholar 

  99. Wang DS, Kusuhara H, Kato Y, et al. Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin. Mol Pharmacol 2003;63:844–848.

    PubMed  CAS  Google Scholar 

  100. Iven H, Brasch H. The effects of antibiotics and uricosuric drugs on the renal elimination of methotrexate and 7-hydroxymethotrexate in rabbits. Cancer Chemother Pharmacol 1988;21:337–342.

    PubMed  CAS  Google Scholar 

  101. Iven H, Brasch H. Influence of the antibiotics piperacillin, doxycycline, and tobramycin on the pharmacokinetics of methotrexate in rabbits. Cancer Chemother Pharmacol 1986;17:218–222.

    PubMed  CAS  Google Scholar 

  102. Najjar TA, Abou-Auda HS, Ghilzai NM. Influence of piperacillin on the pharmacokinetics of methotrexate and 7-hydroxymethotrexate. Cancer Chemother Pharmacol 1998:42:423–428.

    PubMed  CAS  Google Scholar 

  103. Iven H, Brasch H. Cephalosporins increase the renal clearance of methotrexate and 7-hydroxymethotrexate in rabbits. Cancer Chemother Pharmacol 1990;26:139–143.

    PubMed  CAS  Google Scholar 

  104. Yamamoto K, Sawada Y, Mutsashita Y, et al. Delayed elimination of methotrexate associated with piperacillin administration. Ann Pharmacother 1997;31:1261–1262.

    PubMed  CAS  Google Scholar 

  105. Bloom NJ, Ignoffo RJ, Reis CA, et al. Delayed clearance (Cl) of methotrexate (MTX) associated with antibiotics and antiinflammatory agents [abstract]. Clin Res 1986;34:560A.

    Google Scholar 

  106. Nierenberg DW, Mamelok RD. Toxic reaction to methotrexate in a patient receiving penicillin and furosemide: a possible interaction [letter]. Arch Dermatol 1983;119:449,450.

    PubMed  CAS  Google Scholar 

  107. Dean R, Nachman J, Lorenzana AN. Possible methotrexate-mezlocillin interaction. Am J Pediatr Hematol Oncol 1992;14:88–92.

    PubMed  CAS  Google Scholar 

  108. Ronchera CL, Hernández T, Peris JE. Pharmacokinetic interaction between high-dose methotrexate and amoxycillin. Ther Drug Monit 1993;15:375–379.

    PubMed  CAS  Google Scholar 

  109. Titier K, Lagrange F, Péhourcq, Moore N, et al. Pharmacokinetic interaction between high-dose methotrexate and oxacillin. Ther Drug Monit 2002;24:570–572.

    PubMed  Google Scholar 

  110. Herrick AL, Grennan DM, Aarons L. Lack of interaction between methotrexate and penicillins. Rheumatology 1999;38:284–285.

    PubMed  CAS  Google Scholar 

  111. Hill G, Cihlar T, Oo C, et al. The anti-influenza drug oseltamivir exhibits low potential to induce pharmacokinetic drug interactions via renal secretion-correlation of in vivo and in vitro studies. Drug Metab Dispos 2002;30:13–19.

    PubMed  CAS  Google Scholar 

  112. Hardman JG, Limbird LE, Molinoff PB, Ruddon RW, Gilman AG, eds. Goodman and Gilman’s The Pharmacological Basis of Therapeutics. New York: McGraw-Hill, 1996.

    Google Scholar 

  113. Dasgupta A, Sperelakis A, Mason A, et al. Phenytoin-oxacillin interactions in normal and uremic sera. Pharmacotherapy 1997;17:375–378.

    PubMed  CAS  Google Scholar 

  114. Dasgupta A, Dennen DA, Dean R, et al. Displacement of phenytoin from serum protein carriers by antibiotics: studies with ceftriaxone, nafcillin, and sulfamethoxazole. Clin Chem 1991;37:98–100.

    PubMed  CAS  Google Scholar 

  115. Welling PG, Selen SD, Kendall MJ, et al. Probenecid: an unexplained effect on cephalosporin pharmacology. Br J Clin Pharmacol 1979;8:491–495.

    PubMed  CAS  Google Scholar 

  116. Gibaldi M, Schwartz MA. Apparent effect of probenecid on the distribution of penicillins in man. Clin Pharmacol Ther 1968;9:345–349.

    PubMed  CAS  Google Scholar 

  117. Barbhaiya R, Thin RN, Turner P, et al. Clinical pharmacological studies of amoxycillin: effect of probenecid. Br J Vener Dis 1979;55:211–213.

    PubMed  CAS  Google Scholar 

  118. Waller ES, Sharanevych MA, Yakatan GJ. The effect of probenecid on nafcillin disposition. J Clin Pharmacol 1982;22:482–489.

    PubMed  CAS  Google Scholar 

  119. Corvaia L, Li SC, Ioannides-Demos LL, et al. A prospective study of the effects of oral probenecid on the pharmacokinetics of intravenous ticarcillin in patients with cystic fibrosis. J Antimicrob Chemother 1992;30:875–878.

    PubMed  CAS  Google Scholar 

  120. Shanson DC, McNabb R, Hajipieris P. The effect of probenecid on serum amoxycillin concentrations up to 18 hours after a single 3 g oral dose of amoxycillin: possible implications for preventing endocarditis. J Antimicrob Chemother 1984;13:629–632.

    PubMed  CAS  Google Scholar 

  121. Ziv G, Sulman FG. Effects of probenecid on the distribution, elimination, and passage into milk of benzylpenicillin, ampicillin, and cloxacillin. Arch Int Pharmacodyn Ther 1974;207:373–382.

    PubMed  CAS  Google Scholar 

  122. Krogsgaard MR, Hansen BA, Slotsbjerg T, et al. Should probenecid be used to reduce the dicloxacillin dosage in orthopaedic infections? A study of the dicloxacillin-saving effect of probenecid. Pharmacol Toxicol 1994;74:181–184.

    PubMed  CAS  Google Scholar 

  123. Hoffstedt B, Haidl S, Walder M. Influence of probenecid on serum and subcutaneous tissue fluid concentrations of benzylpenicillin and ceftazidime in human volunteers. Eur J Clin Microbiol 1983;2:604–606.

    PubMed  CAS  Google Scholar 

  124. Ganes D, Batra A, Faulkner D, et al. Effect of probenecid on the pharmacokinetics of piperacillin and tazobactam in healthy volunteers. Pharm Res 1991;8:S299.

    Google Scholar 

  125. Babalola CP, Iwheye GB, Olaniyi AA. Effect of proguanil interaction on bioavailability of cloxacillin. J Clin Pharm Ther 2002;27:461–464.

    PubMed  CAS  Google Scholar 

  126. Speck RS, Jawetz E, Gunnison JB. Studies on antibiotic synergism and antagonism. The interference of aureomycin or terramycin with the action of penicillin in infections in mice. Arch Intern Med 1951;88:168–174.

    CAS  Google Scholar 

  127. Gunnison JB, Coleman VR, Jawetz E. Interference of aureomycin and of terramycin with the action of penicillin in vitro. Proc Soc Exp Biol Med 1950;75:549–452.

    PubMed  CAS  Google Scholar 

  128. Chuang YC, Liu JW, Ko WC, et al. In vitro synergism between cefotaxime and minocycline against Vibrio vulnificus. Antimicrob Agents Chemother 1997;41:2214–2217.

    PubMed  CAS  Google Scholar 

  129. Chuang YC, Ko WC, Wang ST, et al. Minocycline and cefotaxime in the treatment of experimental murine Vibrio vulnificus infection. Antimicrob Agents Chemother 1998;42:1319–1322.

    PubMed  CAS  Google Scholar 

  130. Ko WC, Lee HC, Chuang YC, et al. In vitro and in vivo combinations of cefotaxime and minocycline against Aeromonas hydrophilia. Antimicrob Agents Chemother 2001;45:1281–1283.

    PubMed  CAS  Google Scholar 

  131. Lepper MH, Dowling HP. Treatment of pneumococcic meningitis with penicillin compared with penicillin plus aureomycin: studies including observations on an apparent antagonism between penicillin and aureomycin. Arch Intern Med 1951:88:489–494.

    CAS  Google Scholar 

  132. Olsson RA, Kirby JC, Romansky MJ. Pneumococcal meningitis in the adult. Clinical, therapeutic and prognostic aspects in 43 patients. Ann Intern Med 1961;55:545–549.

    PubMed  CAS  Google Scholar 

  133. Strom J. The question of antagonism between penicillin and chlortetracycline, illustrated by therapeutical experiments in scarlatina. Antibiot Med 1955;1:6–12.

    PubMed  CAS  Google Scholar 

  134. Ahern JJ, Kirby WMM. Lack of interference of aureomycin in treatment of pneumococcic pneumonia. Arch Intern Med 1953;91:197–203

    CAS  Google Scholar 

  135. Tryba M. Potentiation of non-depolarizing muscle relaxants of acetylaminopenicillin. Studies on the example of vecuronium [English abstract]. Anaethesist 1985;34:651–655.

    CAS  Google Scholar 

  136. Singh YN, Harvey AL, Marshall IG. Antibiotic-induced paralysis of the mouse phrenic nerve-hemidiaphragm preparation, and reversibility by calcium and by neostigmine. Anesthesiology 1978;48:418–424.

    PubMed  CAS  Google Scholar 

  137. Harwood TN, Moorthy SS. Prolonged vecuronium-induced neuromuscular blockade in children. Anesth Analg 1989;68:534–536.

    PubMed  CAS  Google Scholar 

  138. Mackie K, Pavlin EG. Recurrent paralysis following pipercillin administration. Anesthesiology 1990;72:561–563.

    PubMed  CAS  Google Scholar 

  139. Condon RE, Munshi CA, Arfman RC. Interaction of vecuronium with pipercillin or cefoxitin evaluated in a prospective, randomized, double-blind clinical trial. Am Surg 1995;61:403–406.

    PubMed  CAS  Google Scholar 

  140. Kadlec GJ, Ha LH, Jarboe CH, et al. Effect on ampicillin on theophylline half-life in infants and young children. South Med J 1978;71:1584.

    PubMed  CAS  Google Scholar 

  141. Jonkman JH, Van der Boon WJ, Schoenmaker R, et al. Lack of effect of amoxicillin on theophylline pharmacokinetics. Br J Clin Pharmacol 1985;19:99–101.

    PubMed  CAS  Google Scholar 

  142. Matera MG, Cazzola M, Lampa E, et al. Clinical pharmacokinetics of theophylline during co-treatment with ticarcillin plus clavulanic acid in patients suffering from acute exacerbation of chronic bronchitis. J Chemother 1993;5:233–236.

    PubMed  CAS  Google Scholar 

  143. Cazzola M, Santangelo G, Guidetti E, et al. Influence of sulbactam plus ampicillin on theophylline clearance. Int J Clin Pharmacol Res 1991;11:11–15.

    PubMed  CAS  Google Scholar 

  144. Jonkman JH, Van der Boon WJ, Schoenmaker R, et al. Clinical pharmacokinetics of amoxycillin and theophylline during cotreatment with both medicaments. Chemotherapy 1985;31:329–335.

    PubMed  CAS  Google Scholar 

  145. Hughes GS, Heald DL, Barker KB, et al. The effects of gastric pH and food on the pharmacokinetics of a new oral cephalosporin, cefpodoxime proxetil. Clin Pharmacol Ther 1989;46:674–685.

    PubMed  CAS  Google Scholar 

  146. Saathoff N, Lode H, Neider K, et al. Pharmacokinetics of cefpodoxime proxetil and interactions with an antacid and an H2 receptor antagonist. Antimicrob Agents Chemother 1992;36:796–800.

    PubMed  CAS  Google Scholar 

  147. Spectracef® [package insert]. Purdue Pharmaceutical Products, Stanford, CT, 2003.

    Google Scholar 

  148. Omnicef® [package insert]. Abbott Laboratories North Chicago, IL, 2001.

    Google Scholar 

  149. Satterwhite JH, Cerimele BJ, Coleman DL. Pharmacokinetics of cefaclor AF: effects of age, antacids, and H2-receptor antagonists. Postgrad Med J 1992;68:S3–S9.

    PubMed  CAS  Google Scholar 

  150. Healy DP, Sahia J, Sterling LP, et al. Influence of antacid containing aluminum and magnesium on the pharmacokinetics of cefixime. Antimicrob Agents Chemother 1989;33:1994–1997.

    PubMed  CAS  Google Scholar 

  151. Deslandes A, Camus F, Lacroix C, et al. Effects of nifedipine and diltiazem on pharmacokinetics of cefpodoxime following its oral administration. Antimicrob Agents Chemother 1996;40:2879–2881.

    PubMed  CAS  Google Scholar 

  152. Duverne C, Bouten A, Deslandes A, et al. Modification of cefixime bioavailability by nifedipine in humans: involvement of the dipeptide carrier system. Antimicrob Agents Chemother 1992;36:2462–2467.

    PubMed  CAS  Google Scholar 

  153. Berlioz F, Julien S, Tsocas A, et al. Neural modulation of cephalexin intestinal absorption through the di-and tripeptide brush border transporter of rat jejunum in vivo. J Pharmacol Exp Ther 1999;288:1037–1044.

    PubMed  CAS  Google Scholar 

  154. Marino EL, Vicente MT, Dominguez-Gil A. Influence of cholestyramine on the pharmacokinetic parameters of cefadroxil after simultaneous administration. Int J Pharmaceut 1983;16:23–30.

    CAS  Google Scholar 

  155. Parsons RL, Paddock GM, Hossack GM. Cholestyramine induced antibiotic malabsorption. Chemotherapy 4. In: Williams JD, Geddes AM, eds. Pharmacology of Antibiotics. New York: Plenum, 1975, pp. 191–198.

    Google Scholar 

  156. Kannangara DW, Gallagher K, Lefrock JL. Disulfiram-like reactions with newer cephalosporins: cefmenoxime. Am J Med Sci 1984;287:45–47.

    Google Scholar 

  157. Foster TS, Raehl CL, Wilson HD. Disulfiram-like reaction associated with a parenteral cephalosporin. Am J Hosp Pharm 1980;37:858,859.

    PubMed  CAS  Google Scholar 

  158. Uri JV, Parks DB. Disulfiram-like reaction to certain cephalosporins. Ther Drug Monit 1983;5:219–224.

    PubMed  CAS  Google Scholar 

  159. Ueno K, Tanaka K, Tsujimura K, et al. Impairment of cefdinir absorption by iron ion. Clin Pharmacol Ther 1993;54:473–475.

    PubMed  CAS  Google Scholar 

  160. Shukla UA, Pittman KA, Barbhiaya RH. Pharmacokinetic interactions of cefprozil with food, propantheline, metoclopramide, and probenecid in healthy volunteers. J Clin Pharmacol 1992;32:725–731.

    PubMed  CAS  Google Scholar 

  161. Neu HC. The in vitro activity, human pharmacology, and clinical effectiveness of new β-lactam antibiotics. Annu Rev Pharmacol Toxicol 1982;22:599–642.

    PubMed  CAS  Google Scholar 

  162. Merle-Melet M, Bresler L, Lokiec F, et al. Effects of diclofenac on ceftriaxone pharmacokinetics in humans. Antimicrob Agents Chemother 1992;36:2331–2333.

    PubMed  CAS  Google Scholar 

  163. Andrassy K, Bechtold H, Ritz E. Hypoprothrombinemia caused by cephalosporins. J Antimicrob Chemother 1985;15:133–136.

    PubMed  CAS  Google Scholar 

  164. Freedy HR, Cetnarowski AB, Lumish RM, et al. Cefoperazone-induced coagulopathy. Drug Intell Clin Pharm 1986;20:281–283.

    PubMed  Google Scholar 

  165. Rymer W, Greenlaw CW. Hypoprothrombinemia associated with cefamandole. Drug Intell Clin Pharm 1980;40;780–783.

    Google Scholar 

  166. Osborne JC. Hypoprothrombinemia and bleeding due to cefoperazone [letter]. Ann Intern Med 1985;102:721,722.

    PubMed  CAS  Google Scholar 

  167. Cristiano P. Hypoprothrombinemia associated with cefoperazone treatment. Drug Intell Clin Pharm 1984;18:314–316.

    PubMed  CAS  Google Scholar 

  168. Hooper CA, Haney BB, Stone HH. Gastrointestinal bleeding due to vitamin K deficiency in patients on parenteral cefamandole [letter]. Lancet 1980;1:39,40.

    PubMed  CAS  Google Scholar 

  169. Pakter RL, Russell TR, Mielke CH, et al. Coagulopathy associated with the use of moxalactam. JAMA 1982;248:1100.

    PubMed  CAS  Google Scholar 

  170. Marier RL, Faro S, Sanders CV, et al. Moxalactam in the therapy of serious infections. Antimicrob Agents Chemother 1982;21:650–654.

    PubMed  CAS  Google Scholar 

  171. Angaran DM, Virgil MS, Dias VC. The comparative influence of prophylactic antibiotics on the prothrombin response to warfarin in the postoperative prosthetic cardiac valve patient. Ann Surg 1987;206:155–161.

    PubMed  CAS  Google Scholar 

  172. Angaran DM, Dias VC, Arom KV, et al. The influence of prophylactic antibiotics on the warfarin anticoagulation response in the postoperative prosthetic cardiac valve patient. Cefamandole vs vancomycin. Ann Surg 1984;199:107–111.

    PubMed  CAS  Google Scholar 

  173. Bechtold H, Andrassy K, Jahnchen E, et al. Evidence for impaired hepatic vitamin K1 metabolism in patients treated with N-methyl-thiotetrazole cefalosporins. Thromb Haemost 1984;51:358–361.

    PubMed  CAS  Google Scholar 

  174. Frick P, Riedler G, Brogli H. Dose response and minimal daily requirement for vitamin K in man. Applied Physiol 1967;23:387–389.

    CAS  Google Scholar 

  175. Lipsky J. N-Methyl-thio-tetrazole inhibition of the γ carboxylation of glutamic acid: possible mechanism for antibiotic associated hypothrombinemia. Lancet 1983;2:192,193.

    PubMed  CAS  Google Scholar 

  176. Lipsky J, Lewis J, Novick W. Production of hypoprothrombinemia by moxalactam and 1-methyl-5-thiotetrazole in rats. Antimicrob Agents Chemother 1984;25:380,381.

    PubMed  CAS  Google Scholar 

  177. Verhagen CA, Mattie H, Van Strijen E. The renal clearance of cefuroxime and ceftazidime and the effect of probenecid on their tubular excretion. Br J Clin Pharmacol 1994;37:193–197.

    PubMed  CAS  Google Scholar 

  178. Luthy R, Blaser J, Bonetti A, et al. Comparative multiple-dose pharmacokinetics of cefotaxime, moxalactam, and ceftazidime. Antimicrob Agents Chemother 1981;20:567–575.

    PubMed  CAS  Google Scholar 

  179. LeBel M, Paone RP, Lewis GP. Effect of probenecid on the pharmacokinetics of ceftizoxime. J Antimicrob Chemother 1983;12:147–155.

    PubMed  CAS  Google Scholar 

  180. Reeves DS, Bullock DW, Bywater MJ, et al. The effect of probenecid on the pharmacokinetics and distribution of cefoxitin in healthy volunteers. Br J Clin Pharm 1981;11:353–359.

    CAS  Google Scholar 

  181. Marino EL, Dominquez-Gil A. The pharmacokinetics of cefadroxil associated with probenecid. Int J Clin Pharmacol Ther Toxicol 1981;19:506–508.

    PubMed  CAS  Google Scholar 

  182. Stoeckel K. Pharmacokinetics of Rocephin®, a highly active new cephalosporin with an exceptionally long biological half-life. Chemotherapy 1981;27:42–46.

    PubMed  CAS  Google Scholar 

  183. Kaplan KS, Reisberg BE, Weinstein L. Cephaloridine: antimicrobial activity and pharmacologic behavior. Am J Med Sci 1967;253:667–674.

    PubMed  CAS  Google Scholar 

  184. Duncan WC. Treatment of gonorrhoea with cefazolin plus probenecid. J Infect Dis 1974;130:398–401.

    PubMed  CAS  Google Scholar 

  185. Mischler TW, Sugerman AA, Willard SA, Barmick L, Neiss ES. Influence of probenecid and food on the bioavailability of cephradine in normal male subjects. J Clin Pharmacol 1974;14:604–611.

    PubMed  CAS  Google Scholar 

  186. Tuano SB, Brodie JL. Kirby WM. Cephaloridine vs cephalothin: relation of the kidney to blood level differences after parenteral administration. Antimicrob Agents Chemother 1966;6:101–106.

    PubMed  CAS  Google Scholar 

  187. Griffith RS, Black HR, Brier GL, et al. Effect of probenecid on the blood levels and urinary excretion of cefamandole. Antimicrob Agents Chemother 1977;11:809–812.

    PubMed  CAS  Google Scholar 

  188. Bint AJ, Reeves DS, Holt HA. Effect of probenecid on serum cefoxitin concentrations. J Antimicrob Chemother 1977;3:627,628.

    PubMed  CAS  Google Scholar 

  189. Taylor WA, Holloway WJ. Cephalexin in the treatment of gonorrhea. Int J Clin Pharmacol 1972;6:7–9.

    PubMed  CAS  Google Scholar 

  190. Ko H, Cathcart KS, Griffith DL, et al. Pharmacokinetics of intravenously administered cefmetazole and cefoxitin and effects of probenecid on cefmetazole elimination. Antimicrob Agents Chemother 1989;33:356–361.

    PubMed  CAS  Google Scholar 

  191. Vlasses PH, Holbrook AM, Schrogie J, et al. Effect of orally administered probenecid on the pharmacokinetics of cefoxitin. Antimicrob Agents Chemother 1980;17:847–855.

    PubMed  CAS  Google Scholar 

  192. Spina SP, Dillon EC Jr. Effect of chronic probenecid therapy on cefazolin serum concentrations. Ann Pharmacother 2003;37:621–624.

    PubMed  CAS  Google Scholar 

  193. Stoeckel K, Trueb V, Dubach UC, et al. Effect of probenecid on the elimination and protein binding of ceftriaxone. Eur J Clin Pharmacol 1988;34:151–156.

    PubMed  CAS  Google Scholar 

  194. O’Callaghan CH, Acred P, Harper PB, et al. GR 20263, a new broad-spectrum cephalosporin with antipseudomonal activity. Antimicrob Agents Chemother 1980;17:876–883.

    PubMed  CAS  Google Scholar 

  195. DeSante KA, Israel KS, Brier GL, et al. Effect of probenecid on the pharmacokinetics of moxalactam. Antimicrob Agents Chemother 1982;21:58–61.

    PubMed  CAS  Google Scholar 

  196. Patel IH, Soni PP, Carbone JJ, et al. Lack of probenecid effect on nonrenal excretion of ceftriaxone in anephric patients. J Clin Pharmacol 1990;30:449–453.

    PubMed  CAS  Google Scholar 

  197. Kercsmar CM, Stern RC, Reed MD, et al. Ceftazidime in cystic fibrosis: pharmacokinetics and therapeutic response. J Antimicrob Chemother 1983;12:289–295.

    PubMed  Google Scholar 

  198. Jovanovich JF, Saravolatz LD, Burch K, et al. Failure of probenecid to alter the pharmacokinetics of ceforanide. Antimicrob Agents Chemother 1981;20:530–532.

    PubMed  CAS  Google Scholar 

  199. Pfeifer HJ, Greenblatt DJ, Friedman P. Effects of three antibiotics on theophylline kinetics. Clin Pharmacol Ther 1979;26:36–40.

    PubMed  CAS  Google Scholar 

  200. Bachmann K, Schwartz J, Forney RB, et al. Impact of cefaclor on the pharmacokinetics of theophylline. Ther Drug Monitor 1986;8:151–154.

    CAS  Google Scholar 

  201. Jonkman JH, Van der Boon WJ, Schoenmaker R, et al. Clinical pharmacokinetics of theophylline during co-treatment with cefaclor. Int J Clin Pharmacol Ther Toxicol 1986;24:88–92.

    PubMed  CAS  Google Scholar 

  202. Hammond D, Abate MA. Theophylline toxicity, acute illness, and cefaclor. Drug Intell Clin Pharm 1989;23:339,340.

    CAS  Google Scholar 

  203. Foord RD. Cephaloridine, cephalothin, and the kidney. J Antimicrob Chemother 1975;1(suppl):119–133.

    PubMed  CAS  Google Scholar 

  204. Koch-Weser J, Sidel VW, Federman EB, et al. Adverse effects of sodium colistimethate. Manifestations and specific reaction rates during 317 courses of therapy. Ann Intern Med 1970;72:857–868.

    PubMed  CAS  Google Scholar 

  205. Adler S, Segel DP. Nonoliguric renal failure secondary to sodium colistimethate: a report of four cases. Am J Med Sci 1971;262:109–114.

    PubMed  CAS  Google Scholar 

  206. Plager JE. Association of renal injury with combined cephalothin-gentamicin therapy among patients severely ill with malignant disease. Cancer 1976;37:1937–1943.

    PubMed  CAS  Google Scholar 

  207. Wade JC, Smith CR, Petty BG, et al. Cephalothin plus an aminoglycoside is more nephrotoxic than methicillin plus an aminoglycoside. Lancet 1978;2:604–606.

    PubMed  CAS  Google Scholar 

  208. Gurwich EL, Sula J, Hoy RH. Gentamicin-cephalothin drug reaction. Am J Hosp Pharm 1978;35:1402,1403.

    PubMed  CAS  Google Scholar 

  209. Hansen MM, Kaaber K. Nephrotoxicity in combined cephalothin-gentamicin therapy among patients severely ill with malignant disease. Cancer 1976;37:1937–1943.

    Google Scholar 

  210. Cabanillas F, Burgos RC, Rodriquez RC, et al. Nephrotoxicity of combined cephalothingentamicin regimen. Arch Intern Med 1975;135:850–852.

    PubMed  CAS  Google Scholar 

  211. Fillastre JP, Laumonier R, Humbert G, et al. Acute renal failure associated with combined gentamicin and cephalothin therapy. Br Med J 1973;2:396,397.

    PubMed  CAS  Google Scholar 

  212. Bobrow SL, Jaffe E, Young RC, et al. Anuria and acute tubular necrosis associated with gentamicin and cephalothin. JAMA 1972;222:1546,1547.

    PubMed  CAS  Google Scholar 

  213. Kleinknecht D, Jungers P, Fillastre JP. Nephrotoxicity of cephaloridine. Ann Intern Med 1974;80:421,422.

    PubMed  CAS  Google Scholar 

  214. Dodds MG, Foord RD. Enhancement by potent diuretics of renal tubular necrosis induced by cephaloridine. Br J Pharmacol 1970;40:227–236.

    PubMed  CAS  Google Scholar 

  215. Norrby R, Stenqvist K, Elgefors B, et al. Interaction between cephaloridine and furosemide in man. Scand J Infect Dis 1976;8:209–212.

    PubMed  CAS  Google Scholar 

  216. Simpson IJ. Nephrotoxicity and acute renal failure associated with cephalothin and cephaloridine. N Z Med J 1971;74:312–315.

    PubMed  CAS  Google Scholar 

  217. Trollfors B, Norrby R, Kristianson K. Effects on renal function of treatment with cefoxitin sodium alone or in combination with furosemide. J Antimicrob Chemother 1978;4:S85–S89.

    Google Scholar 

  218. Korn A, Eichler HG, Gasic S. A drug interaction study of ceftriaxone and frusemide in healthy volunteers. Int J Clin Pharmacol Ther Toxicol 1986;24:262–264.

    PubMed  CAS  Google Scholar 

  219. Walstad RA, Dahl K, Hellum KB, et al. The pharmacokinetics of ceftazidime in patients with impaired renal function and concurrent frusemide therapy. Eur J Clin Pharmacol 1988;35:273–279.

    PubMed  CAS  Google Scholar 

  220. Bax RP, Bastain W, Featherstone A, et al. The pharmacokinetics of meropenem in volunteers. J Antimicrob Chemother 1989:24:311–320.

    PubMed  CAS  Google Scholar 

  221. Invanz® [package insert]. Merck and Co., Whitehouse Station, NJ, 2003.

    Google Scholar 

  222. Norrby SR, Alestig K, Ferber F, et al. Pharmacokinetics and tolerance of N-formimidoyl thienamycin (MK0787) in humans. Antimicrob Agents Chemother 1983;23:293–299.

    PubMed  CAS  Google Scholar 

  223. DeTurck BJ, Diltoer MW, Cornelis PJ, et al. Lowering of plasma valproic acid concentrations during concomitant therapy with meropenem and amikacin [letter]. J Antimicrob Chemother 1998;42:563,564.

    CAS  Google Scholar 

  224. Nagai K, Shimizu T, Togo A, et al. Decrease in serum levels of valproic acid during treatment with a new carbapenem, panipenem/βmipron. J Antimicrob Chemother 1997;39:295,296.

    PubMed  CAS  Google Scholar 

  225. Torii M, Takiguchi Y, Saito F, et al. Inhibition by carbapenem antibiotic imipenem of intestinal absorption of valproic acid in rats. Pharm Pharmacol 2001;53:823–829.

    CAS  Google Scholar 

  226. Yokogawa K, Iwashita S, Kubota A, et al. Effect of meropenem on disposition kinetics of valproate and its metabolites in rabbits. Pharm Res 2001;18:1320–1326.

    PubMed  CAS  Google Scholar 

  227. Yamamura N, Imura K, Naganuma H, et al. Panipenem, a carbapenem antibiotic, enhances the glucuronidation of intravenously administered valproic acid in rats. Drug Metab Dispos 1999;27:724–730.

    PubMed  CAS  Google Scholar 

  228. Bösmuller C, Steurer W, Königsrainer A, et al. Increased risk of central nervous system toxicity in patients treated with cyclosporine and imipenem/cilastatin. Nephron 1991;58:362–364.

    PubMed  Google Scholar 

  229. Zazgornik J, Schein W, Heimberger K, et al. Potentiation of neurotoxic side effects by coadministration of imipenem to cyclosporine therapy in a kidney transplant recipient—synergism of side effects or drug interaction. Clin Nephrol 1986;26:265,266.

    PubMed  CAS  Google Scholar 

  230. Mraz W, Sido B, Knedel M, et al. Concomitant immunosuppressive and antibiotic therapy—reduction of cyclosporine A blood levels due to treatment with imipenem/cilastatin. Transplant Proc 1992;24:1704–1708.

    PubMed  CAS  Google Scholar 

  231. Semel JD, Allen N. Seizures in patients simultaneously receiving theophylline and imipenem or ciprofloxacin or metronidazole. South Med J 1991;84:465–468.

    PubMed  CAS  Google Scholar 

  232. Primaxin® [package insert]. Merck and Co., Whitehouse Station, NJ, 2003.

    Google Scholar 

  233. Azactam® [package insert]. Bristol-Myers Squibb, Princeton, NJ, 1999.

    Google Scholar 

  234. Swabb EA, Sugerman AA, Frantz M, et al. Renal handling of the monobactam aztreonam in healthy subjects. Clin Pharmacol Ther 1983;33:609–614.

    PubMed  CAS  Google Scholar 

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Neuhauser, M.M., Danziger, L.H. (2005). β-Lactam Antibiotics. In: Piscitelli, S.C., Rodvold, K.A. (eds) Drug Interactions in Infectious Diseases. Infectious Disease. Humana Press. https://doi.org/10.1385/1-59259-924-9:255

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