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Biomarkers in Breast Cancer pp 293–321Cite as

Detection of Early Tumor Dissemination in Patients With Breast Cancer

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Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

Women who are newly diagnosed with breast cancer have operable disease, and therefore are potentially curable. Nevertheless, a sub-population of these patients, who are thought to be disease free after initial treatment, go on to develop recurrent disease. These recurrences are due to early spread of tumor cells, either systemically (peripheral blood and/or bone marrow) or regionally (lymph nodes) that are not detected by methods routinely employed. To address this problem, more sensitive methodologies of detecting early disseminated tumor cells have been developed over the past decade and a half. This chapter looks at the more important methods and discusses the clinical relevance of these methods.

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Authors and Affiliations

  1. Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

    Debra Hawes MD & Richard J. Cote MD, FRCPATH

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  1. Debra Hawes MD
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  2. Richard J. Cote MD, FRCPATH
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Editors and Affiliations

  1. Division of Medical Oncology, “San Filippo Neri” Hospital, Rome, Italy

    Giampietro Gasparini MD

  2. Breast Oncology Program, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI

    Daniel F. Hayes MD

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© 2006 Humana Press Inc., Totowa, NJ

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Hawes, D., Cote, R.J. (2006). Detection of Early Tumor Dissemination in Patients With Breast Cancer. In: Gasparini, G., Hayes, D.F. (eds) Biomarkers in Breast Cancer. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1385/1-59259-915-X:293

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