p53 as a Prognostic and Predictive Indicator
Cancer is a disease of genes, and the p53 gene appears to be the most frequently mutated gene associated with human cancer. p53 is crucially involved in numerous central pathways determining the life and death of a cell. The information about the functional status of p53 has been considered to be extremely important for estimation of prognosis and the need of further treatment as well as for prediction of response and the selection of the optimal therapy. The aim of this chapter is to evaluate why one of the most promising and most intensively studied markers is not recommended for routine clinical use to date. The pitfalls of the p53 analysis and the challenges of well-designed p53 studies are elucidated and the need of carefully planned studies using an optimal p53 analysis method is pointed out.
Key Wordsp53 biological marker prognostic predictive p53 sequencing p53 immunohistochemistry p53 study design
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