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Tissue Microarrays

State of the Art, Pitfalls, and Promises
  • Chungyeul Kim
  • Soonmyung Paik
Part of the Cancer Drug Discovery and Development book series (CDD&D)

Abstract

In this chapter various methods for tissue array construction are compared and protocols for constructing tissue arrays in multicenter trial setting are provided. Listing of all available arrays for breast cancer including commercial and public sources are provided in the appendix.

Key Words

Cancer multicenter clinical trial tissue array tissue microarray 

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References

  1. 1.
    Kononen J, Bubendorf L, Kallioniemi A, et al. Tissue microarray for high-throughput molecular profiling of tumor specimens. Nat Med 1998;4:844–847.PubMedCrossRefGoogle Scholar
  2. 2.
    Jensen TA. Tissue microarray: advanced techniques. J Histotechnol 2003;26:101–104.Google Scholar
  3. 3.
    Jensen TA, Hammond E. The tissue microarray—a technical guide for histologists. J Histotechnol 2001;24:283–287.Google Scholar
  4. 4.
    Simon R, Mirlacher M, Sauter G. Tissue microarrays. Bio Techniques 2004;36:98–105.Google Scholar
  5. 5.
    Battifora H. The Multitumor (Sausage) Tissue Block: novel method for immuno-histochemical antibody testing. Lab Invest 1986;55:244–248.PubMedGoogle Scholar
  6. 6.
    Battifora H, Mehta P. The checkerboard tissue block. An improved multitissue control block. Lab Invest 1990;63:722–724.PubMedGoogle Scholar
  7. 7.
    Lampkin SR, Allred DC. Preparation of paraffin blocks and sections containing multiple tissue samples using a skin biopsy punch. J Histotechnol 1990;13:121–123.Google Scholar
  8. 8.
    Camp RL, Charette LA, Rimm DL. Validation of tissue microarray technology in breast carcinoma. Lab Invest 2000;80:1943–1949.PubMedCrossRefGoogle Scholar
  9. 9.
    Zhang D, Salto-Tellez M, Putti TC, et al. Reliability of tissue microarrays in detecting protein expression and gene amplification in breast cancer. Mod Pathol 2003;16:79–84.PubMedCrossRefGoogle Scholar
  10. 10.
    Camp RL, Dolled-Filhart M, King BL, Rimm DL. Quantitative analysis of breast cancer tissue microarrays shows that both high and normal levels of HER2 expression are associated with poor outcome. Cancer Res 2003;63:1445–1448.PubMedGoogle Scholar
  11. 11.
    Pollack JR, Sorlie T, Perou CM, et al. Microarray analysis reveals a major direct role of DN A copy number alteration in the transcriptional program of human breast tumors. Proc Natl Acad Sci USA 2002;99:12963–12968.PubMedCrossRefGoogle Scholar
  12. 12.
    Hyman E, Kauraniemi P, Hautaniemi S, et al. Impact of DNA amplification on gene expression patterns in breast cancer. Cancer Res 2002;62:6240–6245.PubMedGoogle Scholar

Copyright information

© Humana Press Inc. 2006

Authors and Affiliations

  • Chungyeul Kim
    • 1
  • Soonmyung Paik
    • 1
  1. 1.Division of PathologyNational Surgical Adjuvant Breast and Bowel Project FoundationPittsburghUSA

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