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Transdifferentiation in the Nervous System

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Neural Development and Stem Cells

Part of the book series: Contemporary Neuroscience ((CNEURO))

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Abstract

In the nervous system, neural stem cells follow a sequential process of development. More differentiated cells have a more limited repertoire of fate choices while fully differentiated cells do not have any alternative fates and may not be able to reenter the cell cycle at all (reviewed in refs. 1 and 2). This progressive restriction of developmental potential is a normal aspect of development, and phenotypic plasticity appears uncommon. To a large part, analysis with gene specific promoters, culture of isolated populations of cells, clonal analysis, and challenge perturbation experiments (3) have confirmed this lack of plasticity and suggested that cells acquire an identity prior to terminal mitosis and this positional and phenotypic identity is difficult to alter (4,5). Overall the idea that there is a cell intrinsic change that restricts the potential of initially pluripotent cells is appealing, as it helps explain how the same regulatory molecules can be reiteratively used at multiple stages and in different tissues to direct differentiation and different fates in multiple distinct lineages (2,6).

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  1. Laboratory of Neurosciences, National Institute on Aging, Baltimore, MD

    Ying Liu & Mahendra S. Rao

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    Mahendra S. Rao MBBS, PhD

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Liu, Y., Rao, M.S. (2006). Transdifferentiation in the Nervous System. In: Rao, M.S. (eds) Neural Development and Stem Cells. Contemporary Neuroscience. Humana Press. https://doi.org/10.1385/1-59259-914-1:249

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