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Diabetic Neuropathy

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Diabetes and Cardiovascular Disease

Part of the book series: Contemporary Cardiology ((CONCARD))

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Abstract

Dysfunction and damage of the somatic and autonomic nervous systems leads to diabetic neuropathy. Simply defined it is characterized by “The presence of symptoms and /or signs of peripheral nerve dysfunction in people with diabetes after the exclusion of other causes” (1). For the practicing physician, a clinically relevant classification is preferred (2) (Table 1). However, to enable quantification for epidemiology and research, particularly for clinical trials, a more detailed definition that includes subclinical neuropathy is required (3,4). An established paradigm for use in clinical trials includes the following:

  • • Neuropathic symptoms (NSS: neuropathy symptom score).

  • • Neuropathic deficits (NIS: neuropathy impairment score).

  • • Motor/sensory nerve conduction velocity (MS:NCV).

  • • quantitative sensory testing (QST)

  • • Autonomic function testing (AFT).

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Authors and Affiliations

  1. Department of Medicine, Manchester Royal Infirmary, Manchester, UK

    Rayaz A. Malik MB.ChB, PhD

  2. Joslin-Beth Israel Deaconess Foot Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

    Aristidis Veves MD, DSc

  3. Department of Surgery, Harvard Medical School, Boston, MA

    Aristidis Veves MD, DSc

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  1. Rayaz A. Malik MB.ChB, PhD
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  2. Aristidis Veves MD, DSc
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Editors and Affiliations

  1. Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

    Michael T. Johnstone MD, CM, FRCP(C)  & Aristidis Veves MD, DSC  & 

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Malik, R.A., Veves, A. (2005). Diabetic Neuropathy. In: Johnstone, M.T., Veves, A. (eds) Diabetes and Cardiovascular Disease. Contemporary Cardiology. Humana Press. https://doi.org/10.1385/1-59259-908-7:381

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  • DOI: https://doi.org/10.1385/1-59259-908-7:381

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