Diabetes and Thrombosis

  • David J. Schneider
  • Burton E. Sobel
Part of the Contemporary Cardiology book series (CONCARD)


Complications of macrovascular disease are responsible for 50% of the deaths in patients with type 2 diabetes mellitus (DM), 27% of the deaths in patients with type 1 diabetes for 35 years or less, and 67% of the deaths in patients with type 1 diabetes for 40 years or more (1,2). The rapid progression of macroangiopathy in patients with type 2 diabetes may reflect diverse phenomena; some intrinsic to the vessel wall; angiopathic factors such as elevated homocysteine and hyperlipidemia; deleterious effects of dysinsulinemia; and excessive or persistent microthrombi with consequent acceleration of vasculopathy secondary to clot-associated mitogens (3,4). As a result of these phenomena, cardiovascular mortality is as high as 15 % in the 10 years after the diagnosis of DM becomes established (5). Because more than 90% of patients with diabetes have type 2 diabetes and because macrovascular disease is the cause of death in most patients with type 2 as opposed to type 1 (insulinopenic) diabetes, type 2 diabetes will be the focus of this chapter. In addition to coronary artery disease (CAD), patients with type 2 diabetes have a high prevalence and rapid progression of peripheral arterial disease (PAD), cerebral vascular disease, and complications of percutaneous coronary intervention including restenosis (6).


Plasminogen Activator Plaque Rupture Platelet Reactivity Arterioscler Thromb Vasc Biol Percutaneous Coronary Interven 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Humana Press Inc., Totowa, NJ 2005

Authors and Affiliations

  • David J. Schneider
    • 1
  • Burton E. Sobel
    • 1
  1. 1.Department of MedicineThe University of Vermont College of MedicineBurlington

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