Abstract
Osteoporosis is a systemic disease currently afflicting approx 44 million Americans; this figure will increase as the population ages. It results in progressive bone mineral loss and concurrent changes in bony architecture that leave bone vulnerable to fracture, often after minimal or no trauma. The spine is the most common site of osteoporotic fracture, with vertebral compression fracture (VCF) occurring in 20% of people over the age of 70 yr, and up to 50% of women 80 yr and older (1,2). Overall, 700,000 people per year in the United States suffer a VCF, exceeding even the frequency of hip fractures (3). Osteoporotic VCFs have been shown to be associated with up to a 30% age-adjusted increase in mortality (4). The cost to society of managing osteoporotic VCF patients in the United States in 1995 was $746 million (5). Possible acute complications of vertebral fracture include cord compression, urinary retention, and ileus (6). Long-term consequences include considerable pain (reported in 35% of detectable VCFs) (7) as well as pulmonary compromise (a 9% loss in predicted forced vital capacity with each vertebral fracture) (8). Other chronic sequelae include deconditioning, deformity, insomnia, and depression, resulting in substantial physical, functional, and psychosocial impairment (8,9).
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References
Heini PF, Walchli B, Berlemann U. Percutaneous transpedicular vertebroplasty with PMMA: operative technique and early results. A prospective study for the treatment of osteoporotic compression fractures. Eur Spine J 2000;9:445–450.
Einhorn TA. Vertebroplasty: an opportunity to do something really good for patients. Spine 2000;25:1051, 1052.
Riggs BL, Melton LJ 3rd. The worldwide problem of osteoporosis: insights afforded by epidemiology. Bone 1995;17:505S–511S.
Kado DM, Browner WS, Palermo L, Nevitt MC, Genant HK, Cummings SR. Vertebral fractures and mortality in older women-a prospective study: Study of Osteoporotic Fractures Research Group. Arch Intern Med 1999;159:1215–1220.
Ray NF, Chan JK, Thamer M, Melton LJ 3rd. Medical expenditures for the treatment of osteoporotic fractures in the United States in 1995: report from the national osteoporosis foundation. J Bone Miner Res 1997;12:24–35.
Bostrom MP, Lane JM. Future directions: augmentation of osteoporotic vertebral bodies. Spine 1997;22:38S–42S.
Cooper C, Atkinson EJ, O’Fallon WM, Melton LJ 3rd. Incidence of clinically diagnosed vertebral fractures: a population-based study in Rochester, Minnesota, 1985–1989. J Bone Miner Res 1992;7:221–227.
Leech JA, Dulberg C, Kellie S, Pattee L, Gay J. Relationship of lung function to severity of osteoporosis in women. Am Rev Respir Dis 1990;141:68–71.
Cotten A, Boutry N, Cortet B, Assaker R, Demondion X, Leblond D, Chastanet P, Duquesnoy B, Deramond H. Percutaneous vertebroplasty: state of the art. Radiographics 1998;18:311–320; discussion 320–313.
Patel U, Skingle S, Campbell GA, Crisp AJ, Boyle IT. Clinical profile of acute vertebral compression fractures in osteoporosis. Br J Rheumatol 1991;30:418–421.
Deramond H, Depriester C, Galibert P, Le Gars D. Percutaneous vertebroplasty with polymethylmethacrylate: technique, indications, and results. Radiol Clin North Am 1998;36:533–546.
Chiras J, Depriester C, Weill A, Sola-Martinez MT, Deramond H. [Percutaneous vertebral surgery: Technics and Indications]. J Neuroradiol 1997;24:45–59.
Jensen ME, Evans AJ, Mathis JM, Kallmes DF, Cloft HJ, Dion JE. Percutaneous poly methylmethacrylate vertebroplasty in the treatment of osteoporotic vertebral body compression fractures: technical aspects. Am J Neuroradiol 1997;18:1897–1904.
Deramond H, Wright NT, Belkoff SM. Temperature elevation caused by bone cement polymerization during vertebroplasty. Bone 1999;25:17S–21S.
Lieberman IH, Dudeney S, Reinhardt MK, Bell G. Initial outcome and efficacy of “kyphoplasty” in the treatment of painful osteoporotic vertebral compression fractures. Spine 2001;26:1631–1638.
Galibert P, Deramond H, Rosat P, Le Gars D. [Preliminary note on the treatment of vertebral angioma by percutaneous acrylic vertebroplasty]. Neurochirurgie 1987;33:166–168.
Bai B, Jazrawi LM, Kummer FJ, Spivak JM. The use of an injectable, biodegradable calcium phosphate bone substitute for the prophylactic augmentation of osteoporotic vertebrae and the management of vertebral compression fractures. Spine 1999;24:1521–1526.
Barr JD, Barr MS, Lemley TJ, McCann RM. Percutaneous vertebroplasty for pain relief and spinal stabilization. Spine 2000;25:923–928.
Mathis JM, Petri M, Naff N. Percutaneous vertebroplasty treatment of steroid-induced osteoporotic compression fractures. Arthritis Rheum 1998;41:171–175.
Cotten A, Dewatre F, Cortet B, Assaker R, Leblond D, Duquesnoy B, Chastanet P, Clarisse J. Percutaneous vertebroplasty for osteolytic metastases and myeloma: effects of the percentage of lesion filling and the leakage of methyl methacrylate at clinical follow-up. Radiology 1996;200:525–530.
Dean JR, Ison KT, Gishen P. The strengthening effect of percutaneous vertebroplasty. Clin Radiol 2000;55:471–476.
Cotten A, Duquesnoy B. Vertebroplasty: current data and future potential. Rev Rhum Engl Ed 1997;64:645–649.
Cortet B, Cotten A, Boutry N, Dewatre F, Flipo RM, Duquesnoy B, Chastanet P, Delcambre B. Percutaneous vertebroplasty in patients with osteolytic metastases or multiple myeloma. Rev Rhum Engl Ed 1997;64:177–183.
Weill A, Chiras J, Simon JM, Rose M, Sola-Martinez T, Enkaoua E. Spinal metastases: indications for and results of percutaneous injection of acrylic surgical cement. Radiology 1996;199:241–247.
Martin JB, Jean B, Sugiu K, San Millan Ruiz D, Piotin M, Murphy K, Rufenacht B, Muster M, Rufenacht DA. Vertebroplasty: clinical experience and follow-up results. Bone 1999;25:11S–15S.
Evans AJ, Jensen ME, Kip KE, DeNardo AJ, Lawler GJ, Negin GA, Remley KB, Boutin SM, Dunnagan SA. Vertebral compression fractures: pain reduction and improvement in functional mobility after percutaneous polymethylmethacrylate vertebroplasty retrospective report of 245 cases. Radiology 2003;226:366–372.
Cohen JE, Lylyk P, Ceratto R, Kaplan L, Umanskyt F, Gomori JM. Percutaneous vertebroplasty: technique and results in 192 procedures. Neurol Res 2004;26:41–49.
Cortet B, Cotten A, Boutry N, Flipo RM, Duquesnoy B, Chastanet P, Delcambre B. Percutaneous vertebroplasty in the treatment of osteoporotic vertebral compression fractures: an open prospective study. J Rheumatol 1999;26:2222–2228.
Cyteval C, Sarrabere MP, Roux JO, Thomas E, Jorgensen C, Blotman F, Sany J, Taourel P. Acute osteoporotic vertebral collapse: open study on percutaneous injection of acrylic surgical cement in 20 patients. Am J Roentgenol 1999;173:1685–1690.
Maynard AS, Jensen ME, Schweickert PA, Marx WF, Short JG, Kallmes DF. Value of bone scan imaging in predicting pain relief from percutaneous vertebroplasty in osteoporotic vertebral fractures. Am J Neuroradiol 2000;21:1807–1812.
Grados F, Depriester C, Cayrolle G, Hardy N, Deramond H, Fardellone P. Long-term observations of vertebral osteoporotic fractures treated by percutaneous vertebroplasty. Rheumatology (Oxf) 2000;39:1410–1414.
Kim AK, Jensen ME, Dion JE, Schweickert PA, Kaufmann TJ, Kallmes DF. Unilateral transpedicular percutaneous vertebroplasty: initial experience. Radiology 2002;222:737–741.
Kaufmann TJ, Jensen ME, Schweickert PA, Marx WF, Kallmes DF. Age of fracture and clinical outcomes of percutaneous vertebroplasty. Am J Neuroradiol 2001;22:1860–1863.
Ryu KS, Park CK, Kim MC, Kang JK. Dose-dependent epidural leakage of polymethylmethacrylate after percutaneous vertebroplasty in patients with osteoporotic vertebral com pression fractures. J Neurosurg 2002;96:56–61.
Kuivaniemi H, Tromp G, Prockop DJ. Mutations in collagen genes: causes of rare and some common diseases in humans. FASEB J 1991;5:2052–2060.
Padovani B, Kasriel O, Brunner P, Peretti-Viton P. Pulmonary embolism caused 1 acrylic cement: a rare complication of percutaneous vertebroplasty. Am J Neuroradiol 1999;20:375–377.
Cunin G, Boissonnet H, Petite H, Blanchat C, Guillemin G. Experimental vertebroplasty using osteoconductive granular material. Spine 2000;25:1070–1076.
Leeson MC, Lippitt SB. Thermal aspects of the use of polymethylmethacrylate in large metaphyseal defects in bone: a clinical review and laboratory study. Clin Orthop 1993:239–245.
Phillips H, Cole PV, Lettin AW. Cardiovascular effects of implanted acrylic bone cement Br Med J 1971;3:460, 461.
Coumans JV, Reinhardt MK, Lieberman IH. Kyphoplasty for vertebral compression fractures: 1-year clinical outcomes from a prospective study. J Neurosurg 2003;99:44–50.
Dudeney S, Lieberman IH, Reinhardt MK, Hussein M. Kyphoplasty in the treatment osteolytic vertebral compression fractures as a result of multiple myeloma. J Clin Oncol 2002;20:2382–2387.
Ledlie JT, Renfro M. Balloon kyphoplasty: one-year outcomes in vertebral body height restoration, chronic pain, and activity levels. J Neurosurg 2003;98:36–42.
Phillips FM, Ho E, Campbell-Hupp M, McNally T, Todd Wetzel F, Gupta P. Early radiographic and clinical results of balloon kyphoplasty for the treatment of osteoporotic vertebral compression fractures. Spine 2003;28:2260–2265.
Garfin SR, Yuan HA, Reiley MA. New technologies in spine: kyphoplasty and vertebroplasty for the treatment of painful osteoporotic compression fractures. Spine 2001;26:1511–1515.
Garfin SR, Reilley MA. Minimally invasive treatment of osteoporotic vertebral body com pression fractures. Spine J 2002;2:76–80.
Hiwatashi A, Moritani T, Numaguchi Y, Westesson PL. Increase in vertebral body height after vertebroplasty. Am J Neuroradiol 2003;24:185–189.
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© 2005 Humana Press Inc., Totowa, NJ
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Togawa, D., Lieberman, I.H. (2005). Vertebral Augmentation for Osteoporotic Compression Fractures. In: Kambin, P. (eds) Arthroscopic and Endoscopic Spinal Surgery. Humana Press. https://doi.org/10.1385/1-59259-904-4:239
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DOI: https://doi.org/10.1385/1-59259-904-4:239
Publisher Name: Humana Press
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