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Stem Cells in Endocrinology pp 183–206Cite as

The Manipulation of Mesenchymal Stem Cells for Bone Repair

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Part of the book series: Contemporary Endocrinology ((COE))

Abstract

Bone homeostasis is a dynamic process consisting of mutually dependent interactions between cells, substrates, and molecular signals that are, in turn, influenced by hormones, mitogens and differentiation factors. In general, when this environment is perturbed as a consequence of disease, including osteoporosis or injury, cell and molecular signals initiate a cascade of genetically programmed repair processes. Depending on the molecular signals and responding cells, the response to injury typically promotes regeneration to a form and function virtually indistinguishable from the preinjured state. However, if the injury becomes too extensive (i.e., becomes of a critical size), these regenerative processes are insufficient for meaningful repair. In these cases, a variety of therapeutic interventions including autografting, grafting from banked bone, or grafts of supplemental bone graft substitute materials are used. For numerous reasons, each of these therapies is associated with an unacceptably high failure rate (1).

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Authors and Affiliations

  1. Division of Plastic and Reconstructive Surgery, Department of Surgery, Oregon Health & Sciences University, Portland, OR

    Shelley R. Winn PhD

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  1. Shelley R. Winn PhD
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  1. Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine, Oregon Health and Sciences University, Portland, Oregon

    Linda B. Lester MS, MD

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© 2005 Humana Press Inc., Totowa, NJ

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Winn, S.R. (2005). The Manipulation of Mesenchymal Stem Cells for Bone Repair. In: Lester, L.B. (eds) Stem Cells in Endocrinology. Contemporary Endocrinology. Humana Press. https://doi.org/10.1385/1-59259-900-1:183

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  • DOI: https://doi.org/10.1385/1-59259-900-1:183

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-407-4

  • Online ISBN: 978-1-59259-900-4

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