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Stem Cells in Endocrinology pp 23–47Cite as

Germ Line Stem Cells

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Part of the book series: Contemporary Endocrinology ((COE))

Abstract

Stem cells are a unique cell population in both biological and clinical contexts. Stem cells are defined by their function to reproduce themselves (self-renewal) and concurrently generate daughter cells that are committed to differentiation (1). The differentiation of stem cells leads to the production of all cell types in a given cell lineage. Furthermore, stem cells conduct this dual function for a lifetime, thereby continuously providing specialized cells that perform normal functions of self-renewing tissues/organs (e.g., bone marrow, intestinal epithelium; see ref. 2). Clinically, these characteristics of stem cells allow them to be a potentially powerful resource for various applications, such as regenerative medicine and gene therapy (3). Our ability to understand stem cell biology is therefore crucial for such practical applications.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada

    Makoto C. Nagano PhD, DVM

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  1. Makoto C. Nagano PhD, DVM
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  1. Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine, Oregon Health and Sciences University, Portland, Oregon

    Linda B. Lester MS, MD

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Nagano, M.C. (2005). Germ Line Stem Cells. In: Lester, L.B. (eds) Stem Cells in Endocrinology. Contemporary Endocrinology. Humana Press. https://doi.org/10.1385/1-59259-900-1:023

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  • DOI: https://doi.org/10.1385/1-59259-900-1:023

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