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Local Delivery Methods Into the CNS

  • Chapter
Minimally Invasive Neurosurgery

Abstract

The earliest forms of therapeutic drug delivery to the central nervous system (CNS) were systemically based intravenous and oral preparations. Despite attempts to increase target concentrations with intraarterial delivery or osmotic opening of the blood-brain barrier (BBB), systemic delivery remains hindered by systemic toxicity and the need for extensive drug modification for effective (80) BBB penetration. These limitations have provided the impetus for developing strategies of localized treatment for CNS disorders, to circumvent the BBB and increase local drug concentration without systemic toxicity.

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Authors and Affiliations

  1. Department of Neurological Surgery, Columbia University College of Physicians and Surgeons, New York, NY

    Timothy W. Vogel MD & Jeffrey N. Bruce MD

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  1. Timothy W. Vogel MD
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  2. Jeffrey N. Bruce MD
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Editors and Affiliations

  1. Department of Neurosurgery, The Children’s Hospital, Harvard Medical School, Boston, MA

    Mark R. Proctor MD  & Peter M. Black MD, PhD  & 

  2. Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA

    Peter M. Black MD, PhD

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Vogel, T.W., Bruce, J.N. (2005). Local Delivery Methods Into the CNS. In: Proctor, M.R., Black, P.M. (eds) Minimally Invasive Neurosurgery. Humana Press. https://doi.org/10.1385/1-59259-899-4:297

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  • DOI: https://doi.org/10.1385/1-59259-899-4:297

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