Tumor Necrosis Factor Family of Ligands and Receptors in Cancer Therapy

  • Anas Younes
  • Andrea Cerutti
Part of the Cancer Drug Discovery and Development book series (CDD&D)


The tumor necrosis factor (TNF) family members are membrane-bound and soluble proteins that play an important physiological role in lymphocyte homeostasis, immunity, inflammation, and calcium metabolism. Abnormalities in the expression or function of these ligands and their receptors have been linked to several human diseases, including autoimmunity and cancer. These observations provided the background for exploring this system to design novel treatment strategies for autoimmune diseases, bone disorders, and cancer. Because the systemic administration of some TNF family members is toxic to normal cells, only a few have a potential therapeutic value. In this concise review, we focus on the potential role of six TNF family members in cancer therapy: CD30 ligand, CD40 ligand, receptor activator of nuclear factor-κB (RANK)/RANK ligand, TNF-related apoptosis-inducing ligand (TRAIL) Apo-2L/TRAIL, BAFF, and APRIL and their receptors.

Key Words

Hodgkin TRAIL apoptosis CD30 CD40 RANK BAFF TACI IL-13 BlyS 


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Copyright information

© Humana Press Inc., Totowa, NJ 2005

Authors and Affiliations

  • Anas Younes
    • 1
  • Andrea Cerutti
    • 1
  1. 1.Department of Lymphoma and MyelomaThe University of Texas, M. D. Anderson Cancer CenterHouston

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