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Bone Metastasis and Pathological Fractures

Bone Tissue Engineering as a Novel Therapy

  • Chapter
Bone Metastasis

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

Bone metastasis commonly occurs in association with solid malignant tumors such as breast, prostate, lung, and renal cancers (1–5). Thirty to seventy percent of cancer patients have skeletal metastasis (6), making the axial skeleton the third most common site for metastasis after lung and liver. Because all of these cancers (breast, prostate, lung, and renal) are common, metastatic bone lesions actually outnumber primary bone malignancies. The spine is affected in approximately half of all patients with bone metastasis (5,6), and involvement of the appendicular skeleton, primarily the femur and humerus, is also common. Metastatic bone lesions can be classified as osteolytic, osteoblastic, mixed, or intertrabecular type based on histology (3,4,7). Bone metastases secondary to breast cancer are typically osteolytic in nature, and these lesions are of particular interest as bone resorption at these sites often leads to pathological fracture. Thus, breast cancer is also the most common cause of pathological fracture (7).

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Author information

Authors and Affiliations

  1. Department of Health Management, Atlantic Veterinary College, Charlottetown, Prince Edward Island, Canada

    Laurie A. McDuffee PhD, DVM, DACVS

  2. Department of Orthopedic Surgery, Hamilton Health Sciences, Hamilton, Ontario, Canada

    Nigel Colterjohn MD

  3. Department of Pathology and Molecular Medicine/Juravinski Cancer Centre, McMaster University, Hamilton, Ontario, Canada

    Gurmit Singh PhD

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  1. Laurie A. McDuffee PhD, DVM, DACVS
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  2. Nigel Colterjohn MD
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  3. Gurmit Singh PhD
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Editor information

Editors and Affiliations

  1. Department of Pathology and Molecular Medicine/Juravinski Cancer Centre, McMaster University, Hamilton, Ontario, Canada

    Gurmit Singh PhD

  2. Calcium Research Laboratory, McGill University Health Centre, Montreal, Quebec, Canada

    Shafaat A. Rabbani MD

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© 2005 Humana Press Inc., Totowa, NJ

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McDuffee, L.A., Colterjohn, N., Singh, G. (2005). Bone Metastasis and Pathological Fractures. In: Singh, G., Rabbani, S.A. (eds) Bone Metastasis. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1385/1-59259-892-7:229

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  • DOI: https://doi.org/10.1385/1-59259-892-7:229

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-403-6

  • Online ISBN: 978-1-59259-892-2

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