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Primary Cerebral Neoplasms as a Cause of Sudden, Unexpected Death

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Forensic Pathology Reviews

Part of the book series: Forensic Pathology Reviews ((FPR,volume 2))

Abstract

This chapter deals with primary intracranial neoplasms as a cause of sudden, unexpected death, giving an overview of our current understanding of both clinical and pathological features of these tumors. A review of the literature and this author’s autopsy files shows that the incidence of sudden death as a result of primary intracranial neoplasms has declined over the last decades. Additionally, a proposal for a guideline for cases of sudden, unexpected death that are presumed to have an intracranial cause is presented.

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References

  1. Mason JK. Forensic Medicine for Lawyers, 3rd ed. Butterworths, London, Dublin, Edinburgh, 1995.

    Google Scholar 

  2. Knight B. Forensic Pathology, 2nd ed. Arnold, London, 1996.

    Google Scholar 

  3. Kleihues P, Cavenee WK. Pathology and Genetics of Tumours of the Nervous System. IARC Press, Lyon, 2000.

    Google Scholar 

  4. Gonzales M. The 2000 World Health Organization classification of tumours of the nervous system. J Clin Neurosci 2001;8:1–3.

    Article  PubMed  CAS  Google Scholar 

  5. Kleihues P, Louis DN, Scheithauer BW, et al. The WHO classification of tumors. J Neuropathol Appl Neurobiol 2002;61:215–225.

    Google Scholar 

  6. Büttner A, Winkler PA, Eisenmenger W, Weis S. Colloid cysts of the third ventricle with fatal outcome: a report of two cases and review of the literature. Int J Legal Med 1997;110:260–266.

    Article  PubMed  Google Scholar 

  7. Huntington RW, Cummings KL, Moe TI, O’Connell HV, Wybel R. Discovery of fatal primary intracranial neoplasms at medicolegal autopsies. Cancer 1965;18:117–127.

    Article  PubMed  Google Scholar 

  8. DiMaio SM, DiMaio VJ, Kirkpatrick JB. Sudden unexpected deaths due to primary intracranial neoplasms. Am J Forensic Med Pathol 1980;1:29–45.

    PubMed  CAS  Google Scholar 

  9. Matschke J, Stavrou D, Püschel K. Sudden unexpected death due to epidermoid cyst of the brain. Am J Forensic Med Pathol 2002;23:368–370.

    Article  PubMed  Google Scholar 

  10. Kernohan JW, Mabon RF, Svien HJ, Adson AW. A simplified classification of gliomas. Proc Staff Meet Mayo Clin 1949;24:71–75.

    CAS  Google Scholar 

  11. Lantos PL, Louis DN, Rosenblum MK, Kleihues P. Tumors of the nervous system. In: Graham DI, Lantos PL, eds. Greenfield’s Neuropathology. Arnold, London, New York, New Delhi, 2002, pp. 767–1051.

    Google Scholar 

  12. Black P, Wen PY. Clinical, imaging and laboratory diagnosis of brain tumors. In: Kaye AH, Laws ER, eds. Brain Tumors. An Encyclopedic Approach. Churchill Livingstone, Edinburgh, Hong Kong, London, 1995, pp. 191–214.

    Google Scholar 

  13. De Angelis LM. Brain tumors. New Eng J Med 2001;344:114–123.

    Article  Google Scholar 

  14. Leestma JE. Forensic Neuropathology. Raven Press, New York, 1988.

    Google Scholar 

  15. Matschke J, Tsokos M, Püschel K. Pilocytic astrocytoma of the brainstem as the cause of death in a 29-year-old man [Article in German]. Rechtsmedizin 2000;10:221–225.

    Article  Google Scholar 

  16. Silbergeld DL, Rostomily RC, Alvord ECJ. The cause of death in patients with glioblastoma is multifactorial: clinical factors and autopsy findings in 117 cases of supratentorial glioblastoma in adults. J Neurooncol 1991; 10:179–185.

    Article  PubMed  CAS  Google Scholar 

  17. Byard RW, Bourne AJ, Hanieh A. Sudden and unexpected death due to hemorrhage from occult central nervous system lesions. A pediatric autopsy study. Pediatr Neurosurg 1991;17:88–94.

    Article  PubMed  Google Scholar 

  18. Black M, Graham DI. Sudden unexplained death in adults. In: Love S, ed. Neuropathology. A Guide for Practising Pathologists (Current Topics in Pathology Vol. 95), Springer, Berlin, Heidelberg, New York, 2000, pp. 125–148.

    Google Scholar 

  19. Black M, Graham DI. Sudden unexplained death in adults caused by intracranial pathology. J Clin Pathol 2002;55:44–50.

    PubMed  CAS  Google Scholar 

  20. Sperhake JP, Matschke J, Orth U, Gal A, Püschel K. Sudden death due to cerebrotendinous xanthomatosis confirmed by mutation analysis. Int J Legal Med 2000;113:110–113.

    Article  PubMed  CAS  Google Scholar 

  21. CBTRUS 1997. Annual Report. Central Brain Tumor Registry of the United States, Chicago, 1998.

    Google Scholar 

  22. CBTRUS 1999. Annual Report. Central Brain Tumor Registry of the United States, Chicago, 2000.

    Google Scholar 

  23. Giles GG, Gonzales MF. Epidemiology of brain tumors and factors in prognosis. In: Kaye AH, Laws ER, eds. Brain Tumors. An Encyclopedic Approach. Churchill Livingstone, Edinburgh, Hong Kong, London, 1995, pp. 47–68.

    Google Scholar 

  24. DiMaio TM, DiMaio DJ. Sudden death due to colloid cysts of third cerebral ventricle. N Y State Med J 1974;74:1832–1834.

    CAS  Google Scholar 

  25. Eberhart CG, Morrison A, Gyure KA, Frazier J, Smialek JE, Troncoso JC. Decreasing incidence of sudden death due to undiagnosed primary intracranial tumors. Arch Pathol Lab Med 2001;125:1024–1030.

    PubMed  CAS  Google Scholar 

  26. Esiri MM. Oppenheimer’s Diagnostic Neuropathology: A Practical Manual, 2nd ed. Blackwell Science, Oxford, 1996.

    Google Scholar 

  27. Büttner A, Gall C, Mall G, Weis S. Unexpected death in persons with symptomatic epilepsy due to glial brain tumors: a report of two cases and review of the literature. Forensic Sci Int 1999;100:127–136.

    Article  PubMed  Google Scholar 

  28. Lindboe CF, Svenes KB, Slordal L. Sudden unexpected death in subjects with undiagnosed gliomas. Am J Forensic Med Pathol 1997;18:271–275.

    Article  PubMed  CAS  Google Scholar 

  29. Shemie S, Jay V, Rutka J, Armstrong D. Acute obstructive hydrocephalus and sudden death in children. Ann Emerg Med 1997;29:524–528.

    Article  PubMed  CAS  Google Scholar 

  30. Matsumoto H, Yamamoto K. A case of sudden death by undiagnosed glioblastoma multiforme. Jpn J Legal Med 1994;47:336–339.

    Google Scholar 

  31. Unger PD, Song S, Taff ML, Schwartz IS. Sudden death in a patient with von Recklinghausen’s neurofibromatosis. Am J Forensic Med Pathol 1984;5:175–179.

    Article  PubMed  CAS  Google Scholar 

  32. Abu Al Ragheb SY, Koussous KJ, Amr SS. Intracranial neoplasms associated with sudden death: a report of seven cases and a review of the literature. Med Sci Law 1986;26:270–272.

    Google Scholar 

  33. Buzzi S, Verdura C, Arlati S, Colecchia M. Sudden death in a child due to rare endocranial neoformation. Med Sci Law 1998;38:176–178.

    PubMed  CAS  Google Scholar 

  34. Gleckman AM, Smith TW. Sudden unexpected death from primary posterior fossa tumors. Am J Forensic Med Pathol 1998;19:303–308.

    Article  PubMed  CAS  Google Scholar 

  35. Prahlow JA, Teot LA, Lantz PE, Stanton CA. Sudden death in epilepsy due to an isolated subependymal giant cell astrocytoma of the septum pellucidum. Am J Forensic Med Pathol 1995;16:30–37.

    PubMed  CAS  Google Scholar 

  36. Rajs J, Rasten-Almqvist P, Nennesmo I. Unexpected death in two young infants mimics SIDS. Am J Forensic Med Pathol 1997;18:384–390.

    Article  PubMed  CAS  Google Scholar 

  37. Poon TP, Solis OG. Sudden death due to massive intraventricular hemorrhage into an unsuspected ependymoma. Surg Neurol 1985;24:63–66.

    Article  PubMed  CAS  Google Scholar 

  38. Mork SJ, Morild, I, Giertsen JC. Subependymoma and unexpected death. Forensic Sci Int 1986;30:275–280.

    Article  PubMed  CAS  Google Scholar 

  39. Schwarz KO, Perper JA, Rozin L. Sudden, unexpected death due to fourth ventricular subependymoma. Am J Forensic Med Pathol 1987;8:153–157.

    Article  PubMed  CAS  Google Scholar 

  40. Nelson J, Frost JL, Schochet SS. Sudden, unexpected death in a 5-year-old boy with an unusual primary intracranial neoplasm. Am J Forensic Med Pathol 1987;8: 148–152.

    PubMed  CAS  Google Scholar 

  41. Balko MG, Schultz DL. Sudden death due to a central neurocytoma. Am J Forensic Med Pathol 1999;20: 180–183.

    Article  PubMed  CAS  Google Scholar 

  42. Zappi E, Zappi M, Breithaupt M, Zugibe FT. Cerebral intraventricular lipoma and sudden death. J Forensic Sci 1993;38:489–492.

    PubMed  CAS  Google Scholar 

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© 2005 Humana Press Inc., Totowa, NJ

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Matschke, J. (2005). Primary Cerebral Neoplasms as a Cause of Sudden, Unexpected Death. In: Tsokos, M. (eds) Forensic Pathology Reviews. Forensic Pathology Reviews, vol 2. Humana Press. https://doi.org/10.1385/1-59259-872-2:045

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  • DOI: https://doi.org/10.1385/1-59259-872-2:045

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-415-9

  • Online ISBN: 978-1-59259-872-4

  • eBook Packages: MedicineMedicine (R0)

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