Abstract
Female sexual dysfunction (FSD) is a complex set of conditions associated with multiple anatomical, physiological, biological, medical, and psychological factors. It can be age-related and appears to be highly prevalent, affecting 20 to 50% of women (1). Data from the National Health and Social Life Survey (NHSLS), a large representative sample of US women, reported that one-third of women experienced loss of sexual interest, and nearly one-fourth reported lack of orgasm during the past year (2). Sexual dysfunctions are associated with problems of mood, self-esteem, quality of life, emotional distress, and relationship difficulties (1).
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References
Basson R, Berman J, Burnett A, et al. (2000) Report of the international consensus development conference on female sexual dysfunction: definitions and classifications. J Urol 163:888–893.
Laumann EO, Paik A, Rosen RC. (1999) Sexual dysfunction in the United States: prevalence and predictors. JAMA 281:537–544.
Berman JR, Goldstein I. (2001) Female sexual dysfunction. Urol Clin North Am 28:405–416.
Kaplan HS. (1974) The New Sex Therapy. New York, NY: Brunner Mazel.
Masters WH, Johnson VE. (1970) Human Sexual Inadequacy. Boston, MA: Little Brown, pp. 214–315.
Rosen RC. (2000) Prevalence and risk factors of sexual dysfunction in men and women. Curr Psychiatry Rep 2:189–195.
American Psychiatric Association. (1994) Diagnostic and Statistical Manual of Mental Disorders, 4th Ed., Washington, DC: American Psychiatric Press, pp. 543, 544,547–549,554–565.
World Health Organization. (1992) International Statistical Classification of Diseases and Related Health Problems, 10th Ed., Geneva, Switerland: World Health Organization, pp. 355–356.
Basson R. (2000) The female sexual response: a different model. J Sex Marital Ther 26:51–65.
Berman JR, Bassuk J. (2002) Physiology and pathophysiology of female sexual function and dysfunction. World J Urol 20:111–118.
Goldstein I, Berman JR. (1998) Vasculogenic female sexual dysfunction: vaginal engorgement and clitoral erectile insufficiency syndromes. Int J Impot Res 10(Suppl 2):S84–S90; discussion S98–S101.
Berman JR, Berman L, Goldstein I. (1999) Female sexual dysfunction: incidence, pathophysiology, evaluation, and treatment options. Urology 54:385–391.
Sipski ML, Rosen RC, Alexander CJ, et al. (2000) Sildenafil effects on sexual and cardiovascular responses in women with spinal cord injury. Urology 55:812–815.
Shafik A. (2000) The role of the levator ani muscle in evacuation, sexual performance and pelvic floor disorders. Int Urogynecol J Pelvic Floor Dysfunct 11:361–376.
Weber AA. (1999) Effects of estrogens and androgens on the libido of women following surgical and natural menopause. Menopausal Med 7:5–8.
Berman JR, McCarthy MM, Kyprianou N. (1998) Effect of estrogen withdrawal on nitric oxide synthase expression and apoptosis in the rat vagina. Urology 51:650–656.
Laan E, van Lunsen RH. (1997) Hormones and sexuality in postmenopausal women: a psychophysiological study. J Psychosom Obstet Gynaecol 18:126–133.
Kow LM, Pfaff DW. (1973) Effects of estrogen treatment on the size of receptive field and response threshold of pudendal nerve in the female rat. Neuroendrocrinology 13:299–313.
Greendale GA, Lee NP, Arriola ER. (1999) The menopause. Lancet 353:571–580.
Davis SR, Tran J. (2001) Testosterone influences libido and well being in women.Trends Endocrinol Metab 12:33–37.
Dennerstein L, Dudley E, Burger H. (2001) Are changes in sexual functioning during midlife due to aging or menopause? Fertil Steril 76:456–460.
Traish AM, Kim N, Min K, et al. (2002) Androgens in female genital sexual arousal function: a biochemical perspective. J Sex Marital Ther 28(Suppl 1):233–244.
Vierhapper H, Nowotny P, Waldhausl W. (1997) Determination of testosterone production rates in men and women using stable isotope/dilution and mass spectrometry. J Clin Endocrinol Metab 82:1492–1496.
Mathur RS, Landgrebe SC, Moody LO, et al. (1985) The effect of estrogen treatment on plasma concentrations of steroid hormones, gonadotropins, prolactin and sex hormone-binding globulin in post-menopausal women. Maturitas 7:129–133.
Rosen RC, Lane RM, Menza M. (1999) Effects of SSRI’s on sexual function: a critical review. J Clin Psychopharmacol 19:67–85.
Coleman CC, King BR, Bolden-Watson C, et al. (2001) A placebo-controlled comparison of the effects on sexual functioning of bupropion sustained release and fluoxetine. Clin Ther 23:1040–1058.
Rosen RC, Leiblum SR. (1995) Treatment of sexual disorders in the 1990s: an integrated approach. J Consult Clin Psychol 63:877–890.
Burchardt M, Burchardt T, Anastasiadis AG, et al. (2002) Sexual dysfunction is common and overlooked in female patients with hypertension. J Sex Marital Ther 28:17–26.
Stuart FM, Hammond DC, Pett MA. (1987) Inhibited sexual desire in women. Arch Sex Behav 16:91–106.
Dunn KM, Croft PR, Hackett GI. (1998) Sexual problems: a study of the prevalence and need for health care in the general population. Fam Pract 15:519–524.
Rosen RC, Taylor JF, Leiblum SR, et al. (1993) Prevalence of sexual dysfunction in women: results of a survey study of 329 women in an outpatient gynecological clinic. J Sex Marital Ther 19:171–188.
Heimann JR, Grafton-Becker V. (1989) Orgasmic disorders in women. New York, NY: Guidford Press.
Jamieson DJ, Steege JF. (1996) The prevalence of dysmenorrhea, dyspareunia, pelvic pain, and irritable bowel syndrome in primary care practices. Obstet Gynecol 87:55–58.
Shokrollahi P, Mirmohamadi M, Mehrabi F, et al. (1999) Prevalence of sexual dysfunction in women seeking services at family planning centers in Tehran. J Sex Marital Ther 25:211–215.
Van Geelen JM, van de Weijer PH, Arnolds H. (1996) Urogenital symptoms and their resulting discomfort in non-institutionalized 50-to-75-year-old Dutch women. Ned Tijdschr Geneeskd 140:713–716.
Stenberg A, Heimer G, Ulmsten U. (1995) The prevalence of urogenital symptoms in postmenopausal women. Maturitas 22(Suppl):S17–S20.
Spector IP, Carey MP. (1990) Incidence and prevalence of the sexual dysfunctions: a critical review. Arch Sex Behav 19:389–409.
Leiblum SR, Wiegel M. (2002) Psychotherapeutic interventions for treating female sexual dysfunction. World J Urol 20:127–136.
Burnett AL, Calvin DC, Silver RI, et al. (1997) Immunohistochemical description of nitric oxide synthase isoforms in human clitoris. J Urol 158:75–78.
Palle C, Bredjkaer HE, Ottesen B, et al. (1990) Vasoactive intestinal polypeptide and human vaginal blood flow: comparison between transvaginal and intravenous administration. Clin Exp Pharmacol Physiol 17:61–68.
Berman JR, Berman LA, Toler SM, et al. (2004) Safety and efficacy of sildenafil citrate for the treatment of female sexual arousal dysfunction: a double blind placebo controlled study. J Urol 170(6 pt 1):2333–2338.
Sipski M, Rosen RC, Alexander CJ, et al. (2000) Sildenafil effects on sexual and cardiovascular responses in women with spinal cord injury. Urology 55:812–815.
Caruso S, Intelisano G, Lupo L, et al. (2001) Premenopausal women affected by sexual arousal disorder treated with Sildenafil: A double blind, crossover, placebo-controlled study. Brit J Obstet Gynaecol 108:623–628.
Shen WW, Urosevich Z, Clayton DO. (1999) Sildenafil in the treatment of female sexual dysfunction induced by selective serotonin reuptake inhibitors. J Reprod Med 44:535–542.
Lobo RA. (2001) Androgens in postmenopausal women: production, possible role, and replacement options. Obstet Gynecol Surv 56:361–376
Guay A, Davis SR. (2002) Testosterone insufficiency in women: fact of fiction? World J Urol 20:106–110.
Guay AT. (2001) Decreased testosterone in regularly menstruating women with decreased libido: a clinical observation. J Sex Marital Ther 27:513–519.
Guay AT, Jacobson J. (2002) Decreased free testosterone and dehydroepiandrosterone-sulfate (DHEA-S) levels in women with decreased libido. J Sex Marital Ther 28(Suppl 1):129–142.
Shifren JL, Baunstein GD, Simon JA, et al. (2000) Transdermal testosterone treatment in women with impaired sexual function after oophorectomy. N Engl J Med 343:682–688.
Tuiten A, Van Honk J, Koppeschaar H, et al. (2000) Time course and effects of testosterone administration on sexual arousal in women. Arch Gen Psychiatry 57:149–153.
Arlt W, Callies F, Van Vlijmen JC, et al. (1999) Dehydroepiandrosterone replacement in women with adrenal insufficiency. N Engl J Med 341:1013–1020.
Davis SR, Walker KZ, Strauss BJ. (2000) Effects of estradiol with and without testosterone on body composition and relationships with lipids in postmenopausal women. Menopause 7:395–401.
Billups KL. (2002) the role of mechanical devices in treating female sexual dysfunction and enhancing the female sexual response. World J Urol 20:137–141.
Hurlbert DF. (1995) The coital alignment technique and directed masturbation: a comparative study on female orgasm. J Sex Marital Ther 21:21–29.
Wilson SK, Delk II JR, Billups KL. (2001) Treating symptoms of female sexual arousal disorder with the eros clitoral therapy device. J Gend Specif Med 4:54–58.
Shabsigh R, Kimoto Y, Amar E, et al. (2004) Economical aspects of sexual dysfunction. In: Jardin A, Wagner G, Khouri S, Giuliano F, Lue TF, Rosen R, eds., Erectile and Sexual Dysfunction, 2nd International Consultation on Erectile and Sexual Dysfunction co-sponsored by the World Health Organization (WHO), International Society of Sexual and Impotence Research (ISSIR) and Societe Internationale d’Urologie (SIU), Health Publications Ltd., pp. 53–64.
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Shabsigh, R., Davis, A.R., Anastasiadis, A.G., Makhsida, N., Yan, G. (2005). Female Sexual Dysfunction. In: Broderick, G.A. (eds) Oral Pharmacotherapy for Male Sexual Dysfunction. Current Clinical Urology. Humana Press. https://doi.org/10.1385/1-59259-871-4:423
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DOI: https://doi.org/10.1385/1-59259-871-4:423
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