Gene Transfer Approaches to Enhancing Bone Healing

  • Oliver Betz
  • Mark Vrahas
  • Axel Baltzer
  • Jay R. Lieberman
  • Paul D. Robbins
  • Christopher H. Evans


Although bone is one of the few organs in the body that can heal spontaneously and restore function without scarring, it has been recognized since the time of Hippocrates that repair is not always satisfactory.Bone healing is inadequate when the loss of bone through, for example, tumor resection or traumatic injury, is extensive enough to produce a critical-sized defect.Healing may also be impaired in much smaller defects, and nonunion following fracture occurs in 5–10%of cases (1, 2, 3).


Gene Therapy Gene Transfer Bone Healing Adenovirus Vector Osseous Lesion 
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Copyright information

© Humana Press Inc., Totowa, NJ 2005

Authors and Affiliations

  • Oliver Betz
    • 1
  • Mark Vrahas
    • 1
  • Axel Baltzer
    • 2
  • Jay R. Lieberman
    • 3
  • Paul D. Robbins
    • 4
  • Christopher H. Evans
    • 1
  1. 1.Center for Molecular OrthopaedicsHarvard Medical SchoolBoston
  2. 2.Praxis und Klink für OrthopaedieDusseldorfGermany
  3. 3.Department of Orthopaedic Surgery, David Geffen School of MedicineUniversity of CaliforniaLos Angeles
  4. 4.Department of Molecular Genetics and BiochemistryUniversity of Pittsburgh School of MedicinePittsburgh

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