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Oculomotor Dysfunction

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Parkinson’s Disease and Nonmotor Dysfunction

Part of the book series: Current Clinical Neurology ((CCNEU))

Abstract

The oculomotor system is known to engage key structures within the basal ganglia and respond to dopaminergic stimulation. Therefore, it is unsurprising that Parkinson’s disease (PD) should be associated with distinctive abnormalities of eye movement generation and control. Briefly outlined is the functional neuroanatomy of the oculomotor system, then the examination of the abnormalities seen in PD, their value in the differential diagnosis of Parkinsonism, and their response to pharmacological and surgical treatment are discussed. The chapter concludes with a novel hypothesis that attempts to reconcile saccadic hypometria, the most characteristic oculomotor deficit in PD, with current models of basal ganglia function.

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Authors and Affiliations

  1. Division of Neuroscience and Psychological Medicine, Imperial College, London, England, UK

    Parashkev Nachev MA, BM, BCh, MRCP(UK) & Christopher Kennard MBBS, PHD, FRCP, FmedSci

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  1. Parashkev Nachev MA, BM, BCh, MRCP(UK)
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  2. Christopher Kennard MBBS, PHD, FRCP, FmedSci
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Editor information

Editors and Affiliations

  1. Department of Neurology, University of Tennessee Health Science Center, Memphis, TN

    Ronald F. Pfeiffer MD

  2. Department of Neurology, State University of New York, Downstate Medical Center, Brooklyn, NY

    Ivan Bodis-Wollner MD, DSc

  3. Department of Ophthalmology, State University of New York, Downstate Medical Center, Brooklyn, NY

    Ivan Bodis-Wollner MD, DSc

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© 2005 Humana Press Inc., Totowa, NJ

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Nachev, P., Kennard, C. (2005). Oculomotor Dysfunction. In: Pfeiffer, R.F., Bodis-Wollner, I. (eds) Parkinson’s Disease and Nonmotor Dysfunction. Current Clinical Neurology. Humana Press. https://doi.org/10.1385/1-59259-859-5:271

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  • DOI: https://doi.org/10.1385/1-59259-859-5:271

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-316-9

  • Online ISBN: 978-1-59259-859-5

  • eBook Packages: MedicineMedicine (R0)

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