Abstract
Pulmonary complications remain a primary cause of morbidity and mortality in Parkinson’s disease (PD). Obstructive and restrictive airway deficits are related to disordered motor control of the respiratory musculature. Although this may sometimes lead to overt symptoms, such as stridor and respiratory failure, it more commonly results in silent aspiration and atelectasis, predisposing patients to pneumonia. Anti-Parkinson medications may produce pulmonary side effects (e.g., pleuropulmonary fibrosis associated with ergot-based dopamine agonists). Finally, motor fluctuations in patients with advanced PD may affect the respiratory system. Recognizing these pulmonary complications will assist the clinician in appropriately managing the disease and potentially reducing the impact of the abnormal respiratory system on the overall health of the patient with PD.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Parkinson J. An Essay on the Shaking Palsy. Sherwood, Nealy and Jones, London, 1817.
Hoehn MM, Yahr MD. Parkinsonism: onset, progression and mortality. Neurology 1967;17:427–442.
Mosewich RK, Rajput AH, Shuaib A, et al. Pulmonary embolism: an under-recognized yet frequent cause of death in Parkinsonism. Mov Disord 1994;9:350–352.
Nakashima K, Maeda M, Tabata M, et al. Prognosis of Parkinson’s Disease in Japan. Tottori University Parkinson’s Disease Epidemiology (TUPDE) Study Group Eur Neurol 1997;38:60–63.
Morgante L, Salemi G, Meneghini F, et al. Parkinson disease survival: a population-based study. Arch Neurol 2000;57:507–512.
Beyer MK, Herlofsen K, Arsland D, Larsen JP. Causes of death in a community-based study of Parkinson’s disease. Acta Neurol Scand 2001;103:7–11.
Baker KK, Ramig LO, Luschei ES, Smith ME. Thyroarytenoid muscle activity associated with hypophonia in Parkinson disease and aging. Neurology 1998;51:1592–1598.
Logemann JA, Fisher HB, Boshes B, Blonsky ER. Frequency and cooccurrence of vocal tract dysfunction in the speech of a large sample of Parkinson patients. J Speech Hear Disord 1978;43:47–57.
Hartelius L, Svensson P. Speech and swallowing symptoms associated with Parkinson’s disease and multiple sclerosis: a survey. Folia Phon Log 1994;46:9–17.
Liotti M, Ramig LO, Vogel D, et al. Hypophonia in Parkinson’s disease. Neural correlates of voice treatment revealed by PET. Neurology 2003;60:432–440.
Swart BJM, Willemse SC, Maassen BAM, Horstink MWIM. Improvement of voicing in patients with Parkinson’s disease by speech therapy. Neurology 2003;60:498–500.
Berke GS, Gerratt B, Kreiman J, Jackson K. Treatment of Parkinson hypophonia with percutaneous collagen augmentation. Laryngoscope 1999;1098:1295–1299.
Kim SH, Kearney JJ, Atkins JP. Percutaneous collagen augmentation for treatment of parkinsonian hypophonia. Otolaryngol Head Neck Surg 2002;126:653–656.
Jankovic J, Cardoso F, Grossman RG, Hamilton WJ. Outcome after stereotactic thalamotomy for parkinsonian, essential, and other types of tremor. Neurosurgery 1995;37:680–687.
Lang AE, Duff J, Saint-Cyr JA, et al. Posteroventral medial pallidotomy in Parkinson’s disease. J Neurol 1999;246(Suppl 2):28–41.
Okun MS, Stover NP, Subramanian T, et al. Complications of gamma knife surgery for Parkinson’s disease. Arch Neurol 2001;58:1995–2002.
Romito LM, Scerrati M, Contarin MF, et al. Long-term follow up of subthalamic nucleus stimulation in Parkinson’s disease. Neurology 2002;58:15.
Neu HC, Connolly JJ, Jr., Schwertley FW, et al. Obstructive respiratory dysfunction in parkinsonian patients. Am Rev Respir Dis 1967;95:33–47.
Obenour WH, Stevens PM, Cohen AA, McCutchen JJ. The causes of abnormal pulmonary function in Parkinson’s disease. Am Rev Respir Dis 1972;105:382–387.
Vincken WG, Gauthier SG, Dollfuss RE, et al. Involvement of upper-airway muscles in extrapyramidal disorders. A cause of airflow limitation. N Engl J Med 1984;311:438–442.
Hovestadt A, Bogaard JM, Meerwaldt JD, et al. Pulmonary function in Parkinson’s disease. J Neurol Neurosurg Psychiatry 1989;52:329–333.
Read D, Young A. Stridor and Parkinsonism. Postgrad Med J 1983;59:520–521.
Fink ME, Klebanoff LM, Lennihan L, Fahn S. Acute respiratory failure during drug manipulation in patients with Parkinson’s disease. Neurology 1989;39:348.
Riley DE, Grossman G, Martin L. Acute respiratory failure from dopamine agonist withdrawal. Neurology 1992;42:1843–1844.
Easdown LJ, Tessler MJ, Minuk J. Upper airway involvement in Parkinson’s disease resulting in postoperative respiratory failure. Can J Anaesth 1995;42:344–347.
Langer H, Woolf CR. Changes in pulmonary function Parkinson’s syndrome after treatment with L-dopa. Am Rev Respir Dis 1971;104:440–442.
de Bruin PF, de Bruin VM, Lees AJ, Pride NB. Effects of treatment on airway dynamics and respiratory muscle strength in Parkinson’s disease. Am Rev Respir Dis 1993;148:1576–1580.
Herer B, Arnulf I, Housset B. Effects of levodopa on pulmonary function in Parkinson’s disease. Chest 2001;119:387–393.
Izquierdo-Alonso JL, Jimenez-Jimenez FJ, Cabrera-Valdivia F, Mansilla-Lesmes M. Airway dysfunction in patients with Parkinson’s disease. Lung 1994;172:47–55.
Sabate M, Gonzalez I, Ruperez F, Rodriguez M. Obstructive and restrictive pulmonary dysfunctions in Parkinson’s disease. J Neurol Sci 1996;138:114–119.
Pepper PV, Goldstein MK. Postoperative complications in Parkinson’s disease. J Am Geriatr Soc 1999;47:967–972.
Fontana GA, Pantaleo T, Lavorini F, et al. Defective motor control of coughing in Parkinson’s disease. Am J Respir Crit Care Med 1998;158:458–464.
Galvez-Jimenez N, Lang AE. Perioperative problems in Parkinson’s disease and their management: apomorphine with rectal domperidone. Can J Neurol Sci 1996;23:198–203.
Chester CS, Gottfried SB, Cameron DI, Strohl KP. Pathophysiological findings in a patient with Shy-Drager and alveolar hypoventilation syndromes. Chest 1988;94:212–214.
Apps MCP, Scheaff PC, Ingram DA, et al. Respiration and sleep in Parkinson’s disease. J Neurol Neurosurg Psychiatry 1985;48:1240–1245.
Silber MH, Levine S. Stridor and death in multiple system atrophy. Mov Disord 2000;15:699–704.
Estenne M, Hubert M, De Troyer A. Respiratory-muscle involvement in Parkinson’s disease. N Engl J Med 1984;311:1516–1517.
Schwab RD, England AC, Peterson E. Akinesia, in Parkinson’s disease. Neurology 1959;9:65–72.
Nugent CA, Harris HW, Cohn J, et al. Dyspnea as a symptom in Parkinson’s syndrome. Am Rev Tuberc 1958;78:682–691.
Tzelepis GE, McCool FD, Friedman JH, Hoppin FG, Jr. Respiratory muscle dysfunction in Parkinson’s disease. Am Rev Respir Dis 1988;138:266–271.
Sabate M, Rodriguez M, Mendez E, et al. Obstructive and restrictive pulmonary dysfunction increases disability in Parkinson disease. Arch Phys Med Rehabil 1996;77:29–34.
Bhatt MH, Keenan SP, Fleetham JA, Calne DB. Pleuropulmonary disease associated with dopamine agonist therapy. Ann Neurol 1991;30:613–616.
Geminiani G, Fetoni V, Genitrini S, et al. Cabergoline in Parkinson’s disease complicated by motor fluctuations. Mov Disord 1996;11:495–500.
McElvaney NG, Wilcox PG, Churg A, Fleetham JA. Pleuropulmonary disease during bromocriptine treatment of Parkinson’s disease. Arch Intern Med 1988;148:2231–2236.
Todman DH, Oliver WA, Edwards RL. Pleuropulmonary fibrosis due to bromocriptine treatment for Parkinson’s disease. Clin Exp Neurol 1990;27:79–82.
LeWitt PA, Calne DB. Pleuropulmonary changes during long-term bromocriptine treatment for Parkinson’s disease. Lancet 1981;1:44–45.
Hillerdal G, Lee J, Blomkvist A, et al. Pleural disease during treatment with bromocriptine in patients previously exposed to asbestos. Eur Respir J 1997;10:2711–2715.
Weiner WJ, Goetz CG, Nausieda PA, Klawans HL. Respiratory dyskinesias: extrapyramidal dysfunction and dyspnea. Ann Intern Med 1978;88:327–331.
Zupnick HM, Brown LK, Miller A, Moros DA. Respiratory dysfunction due to L-dopa therapy for Parkinsonism, diagnosis using serial pulmonary function tests and respiratory inductive plethysmography. Am J Med 1990;89:109–114.
Corbin DO, Williams AC. Stridor during dystonic phases of Parkinson’s disease. J Neurol Neurosurg Psychiatry 1987;50:821–822.
Hartman DE. Stridor during dystonia phases of Parkinson’s disease. J Neurol Neurosurg Psychiatry 1988;51:161.
Vazquez A, Jimenez-Jimenez FJ, Garcia-Ruiz P, Garcia-Urra D. “Panic attacks” in Parkinson’s disease. A long-term complication of levodopa therapy. Acta Neurol Scand 1993;87:14–18.
Stacy M. Pharmacotherapy for advanced Parkinson’s disease. Pharmacotherapy 2000;20:8S–16S.
Witjas T, Kaphan E, Azulay JP, et al. Nonmotor fluctuations in Parkinson’s Disease. Neurology 2002;59:408–413.
Canning CG, Alison JA, Allen NE, Groeller H. Parkinson’s disease: an investigation of exercise capacity, respiratory function, and gait. Arch Phys Med Rehabil 1997;78:199–207.
Bergen JL, Toole T, Elliott RG, et al. Aerobic exercise intervention improves aerobic capacity and movement initiation in Parkinson’s disease patients. Neurorehabilitation 2002;17:161–168.
Koseoglu F, Inan L, Ozel S, et al. The effects of a pulmonary rehabilitation program on pulmonary function tests and exercise tolerance in patients with Parkinson’s disease. Funct Neurol 1997;12:319–325.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2005 Humana Press Inc., Totowa, NJ
About this chapter
Cite this chapter
Shill, H.A. (2005). Respiratory Dysfunction. In: Pfeiffer, R.F., Bodis-Wollner, I. (eds) Parkinson’s Disease and Nonmotor Dysfunction. Current Clinical Neurology. Humana Press. https://doi.org/10.1385/1-59259-859-5:173
Download citation
DOI: https://doi.org/10.1385/1-59259-859-5:173
Publisher Name: Humana Press
Print ISBN: 978-1-58829-316-9
Online ISBN: 978-1-59259-859-5
eBook Packages: MedicineMedicine (R0)