Skip to main content
SpringerLink
Log in
Book cover

Neurological and Psychiatric Disorders pp 3–27Cite as

Neural Principles of Neurological and Psychiatric Disorders

  • Chapter

  • 1094 Accesses

Part of the book series: Current Clinical Neurology ((CCNEU))

Abstract

Recent progress in understanding the neurobiology and pharmacology of brain neurotransmitters and their neural circuits and pathways has been remarkable and serves as the foundation for in-depth preclinical research on neurological and psychiatric disorders. Most of the neurotransmitter receptors have been cloned and their anatomical localization and distribution have been clarified using advanced neurochemical methods. Novel discoveries have greatly stimulated clinical studies in the neuropathophysiology and neurogenetics of brain disorders. Sophisticated developments in neuroimaging techniques have yielded revolutionary insights into the complexity of maldevelopment or dysfunction of neuronal elements in neurological and psychiatric disorders, and have assisted in the rational design of novel neuropsychotropic agents for improved treatment of these disorders.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Baldessarini RJ, Tarazi FI. Drugs and the treatment of psychiatric disorders. In: Hardman JG, Limbird LE, eds. Goodman and Gilman’s The pharmacologic basis of therapeutics. 10th ed. New York: McGraw-Hill, 2001:485–520.

    Google Scholar 

  2. Baldessarini RJ, Tarazi FI. Brain dopamine receptors: A primer on their current status, basic and clinical. Harvard Rev Psychiatry 1996;3:301–325.

    CAS  Google Scholar 

  3. Cooper JR, Bloom EF, Roth RH. The biochemical basis of neuropharmacology. 8th ed. New York: Oxford University Press, 2003.

    Google Scholar 

  4. Lindvall O, Bjorklund A. Dopamine and norepinephrine containing neuron systems: their anatomy in the rat brain. In: Emson PC, ed. Chemical Neuroanatomy. New York: Raven Press, 1983:229–255.

    Google Scholar 

  5. Bylund DB, Eikenberg DC, Hieble JP, et al. International Union of Pharmacology nomenclature of adrenoceptors. Pharmacol Rev 1994;46:121–136.

    PubMed  CAS  Google Scholar 

  6. Hieble JP, Ruffolo RR Jr. Functions mediated by b-adrenoceptor activation. In: Ruffolo RR Jr, ed. Progress in basic and clinical pharmacology, vol. 7, b-Adrenoceptors: molecular biology, biochemistry and pharmacology. Basel: Karger, 1991:1–25.

    Google Scholar 

  7. Tork I. Anatomy of the serotonergic system. Ann NY Acad Sci 1990;600:9–35.

    Article  PubMed  CAS  Google Scholar 

  8. Barnes NM, Sharp T. A review of central 5-HT receptors and their function. Neuropharmacology 1999; 38:1083–1152.

    Article  PubMed  CAS  Google Scholar 

  9. Millan MJ. Improving the treatment of schizophrenia: focus on serotonin 5-HT1A receptors. J Pharmacol Exp Ther 2000;295:853–861

    PubMed  CAS  Google Scholar 

  10. Tarazi FI, Zhang K, Baldessarini RJ. Long-term effects of olanzapine, risperidone, and quetiapine on dopamine receptor types in regions of rat brain: implications for antipsychotic drug treatment. J Pharmacol Exp Ther 2001; 297:711–717.

    PubMed  CAS  Google Scholar 

  11. Tarazi FI, Campbell A, Yeghiayan SK, Baldessarini RJ. Localization of dopamine receptor subtypes in caudate-putamen and nucleus accumbens septi of rat brain: comparison of D1-, D2-, and D4-like receptors. Neuroscience 1998;83:169–176.

    Article  PubMed  CAS  Google Scholar 

  12. Young AB, Frey KA, Agranoff BW. Receptor assays: in vitro and in vivo. In: Phelps M, Mazziotta J, Schelbert H, eds. Positron Emission Tomography and Autoradiography: Principles and Applications for the Brain and Heart. New York: Raven Press, 1986:73–111.

    Google Scholar 

  13. Sternberger LA. Immunocytochemistry. New York: Wiley, 1986.

    Google Scholar 

  14. Mudgett-Hunter M. Monoclonal antibodies. In: Fozzard H, Haber E, Jennings R, Katz H, Morgan H, eds. The Heart and Cardiovascular System. New York: Raven Press, 1986:189–201.

    Google Scholar 

  15. Eberwine JH, Valentino KL, Barchas JD. In Situ Hybridization in Neurobiology. New York: Oxford University Press, 1994.

    Google Scholar 

  16. Chesselet M-F. In Situ Hybridization Histochemistry. Neurobiology. Boca Raton: CRC Press, 1990.

    Google Scholar 

  17. Graybiel AM. Neurotransmitters and neuromodulators in the basal ganglia. Trends Neurosci 1990;13: 244–254.

    Article  PubMed  CAS  Google Scholar 

  18. Gerfen CR. The neostriatal mosaic: multiple levels of compartmental organization. Trends Neurosci 1992; 15:133–139.

    Article  PubMed  CAS  Google Scholar 

  19. Alexander GE, Crutcher MD. Functional architecture of basal ganglia circuits: neural substrates of parallel processing. Trends Neursci 1990;13:266–271.

    Article  CAS  Google Scholar 

  20. LeDoux JE. The Emotional Brain. New York: Simon and Schuster, 1996.

    Google Scholar 

  21. Iversen S, Kupfermann I, Kandel ER. Emotional states and feelings. In: Kandel ER, Schwartz JH, Jessell TM, eds. Principles of Neural Science. 4th edition. New York: McGraw-Hill, 2000: 982–997.

    Google Scholar 

  22. Aggleton JP. The contribution of the amygdala to normal and abnormal emotional states. Trends Neurosci 1993;16:328–333.

    Article  PubMed  CAS  Google Scholar 

  23. Deutch AY. Prefrontal cortical dopamine systems and the elaboration of functional corticostriatal circuits: implications for schizophrenia and Parkinson’s disease. J Neural Transm 1993;91:197–221.

    Article  CAS  Google Scholar 

  24. Malison RT. Positron emission tomography and single-photon emission computed tomography. Methods and applications in substance abuse research, In: Kaufman MJ, ed. Brain Imaging in Substance Abuse: Research, Clinical, and Forensic Applications. Totowa, NJ: Humana Press, 2001:29–46.

    Google Scholar 

  25. Volkow ND, Fowler JS, Wang GJ. Positron Emission Tomography and Single Photon Emission Computed Tomography in Substance Abuse Research. Seminars Nuclear Med 2003;XXXIII:114–128.

    Article  Google Scholar 

  26. Fowler JS, Volkow ND, Wang G-J, Ding Y-S. 2-Deoxy-2-[18F]Fluoro-D-Glucose and alternative radiotracers for positron emission tomography imaging using the human brain as a model. Seminars Nuclear Med 2004;XXXIV: 112–121.

    Article  Google Scholar 

  27. Logothetis NK, Wandell BA. Interpreting the BOLD signal. Ann Rev Physiol 2004;66:735–769.

    Article  CAS  Google Scholar 

  28. Kim D-S, Garwood M. High-field magnetic resonance techniques for brain research. Curr Opin Neurobiol 2003;13:612–619.

    Article  PubMed  CAS  Google Scholar 

  29. Meade TJ, Taylor AK, Bull SR. New magnetic resonance contrast agents as biochemical reporters. Curr Opin Neurobiol 2003;13:597–602.

    Article  PubMed  CAS  Google Scholar 

  30. Wong EC, Buxton RB, Frank LR. Implementation of quantitative perfusion imaging techniques for functional brain mapping using pulsed arterial spin labeling. NMR Biomed 1997;10:237–249.

    Article  PubMed  CAS  Google Scholar 

  31. Renshaw PF, Frederick B, Maas LC III. Fundamentals of magnetic resonance. In: Kaufman MJ, ed. Brain Imaging in Substance Abuse: Research, Clinical, and Forensic Applications. Totowa, NJ: Humana Press, 2001:47–76.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Psychiatric Neuroscience, McLean Hospital, Boston, MA

    Frank I. Tarazi PhD, MSc

  2. Department of Psychiatry, Harvard Medical School, Boston, MA

    Frank I. Tarazi PhD, MSc

  3. Brain Imaging Center, McLean Hospital, Boston, MA

    Marc J. Kaufman PhD

  4. Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA

    Marc J. Kaufman PhD

Authors
  1. Frank I. Tarazi PhD, MSc
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Marc J. Kaufman PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA

    Frank I. Tarazi PhD, MSc

  2. Laboratory of Psychiatric Neuroscience, McLean Hospital, Belmont, MA

    Frank I. Tarazi PhD, MSc

  3. Department of Pharmacology and Neuroscience, Univesity of North Texas Health Science Center, Fort Worth, TX

    John A. Schetz PhD

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Humana Press Inc., Totowa, NJ

About this chapter

Cite this chapter

Tarazi, F.I., Kaufman, M.J. (2005). Neural Principles of Neurological and Psychiatric Disorders. In: Tarazi, F.I., Schetz, J.A. (eds) Neurological and Psychiatric Disorders. Current Clinical Neurology. Humana Press. https://doi.org/10.1385/1-59259-856-0:003

Download citation

  • DOI: https://doi.org/10.1385/1-59259-856-0:003

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-369-5

  • Online ISBN: 978-1-59259-856-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation