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Repair and Neuroprotective Strategies in Multiple Sclerosis

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Multiple Sclerosis

Part of the book series: Current Clinical Neurology ((CCNEU))

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Abstract

Multiple sclerosis (MS) is a demyelinating and inflammatory disease of the central nervous system (CNS). The destruction of the oligodendrocyte-derived myelin lamellae leads to loss of nerve insulation and results in impairment of fast saltatory conduction. Axons and neurons are also damaged and lost in the disease process (1), and cell repopulation is hampered by the inability of mature neurons to undergo cell division. An attractive approach for reestablishing electrochemical circuits in MS would be to restore the function or number of myelin-generating oligodendrocytes in early lesions, to act as bridges that guide and promote axonal regeneration.

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  1. Department of Neurology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA

    Fernando Dangond MD

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  1. Multiple Sclerosis Center, Department of Neurology, University of California, Irvine, CA

    Michael J. Olek DO

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© 2005 Humana Press Inc., Totowa, NJ

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Dangond, F. (2005). Repair and Neuroprotective Strategies in Multiple Sclerosis. In: Olek, M.J. (eds) Multiple Sclerosis. Current Clinical Neurology. Humana Press. https://doi.org/10.1385/1-59259-855-2:193

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  • DOI: https://doi.org/10.1385/1-59259-855-2:193

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-033-5

  • Online ISBN: 978-1-59259-855-7

  • eBook Packages: MedicineMedicine (R0)

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