Abstract
Multiple sclerosis (MS) has emerged as a treatable disorder with several disease-modifying therapies (DMTs) now licensed in the United States for MS treatment. These are interferon (IFN)-β-1a (two formulations, Avonex and Rebif), IFN-β-1b (Betaseron), glatiramer acetate (GA) (Copaxone), and mitoxantrone (Novantrone). Although all five DMTs were tested in phase III randomized controlled trials (RCTs) and shown to be superior to placebo, no therapy has ever been shown to halt disease progression (1–5). Because MS is a chronic, unpredictable disease and clinically variable from patient to patient, treatment choices for patients with MS can pose a dilemma, despite the plethora of information. Nonetheless, the use of DMTs in definite relapsing-remitting MS (RRMS) is well established.
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© 2005 Humana Press Inc., Totowa, NJ
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Tselis, A.C., Khan, O.A. (2005). Multiple Sclerosis. In: Olek, M.J. (eds) Multiple Sclerosis. Current Clinical Neurology. Humana Press. https://doi.org/10.1385/1-59259-855-2:131
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DOI: https://doi.org/10.1385/1-59259-855-2:131
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