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Cognitive Dysfunction in Multiple Sclerosis

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Multiple Sclerosis

Part of the book series: Current Clinical Neurology ((CCNEU))

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Abstract

Cognitive dysfunction is one of the more common symptoms of multiple sclerosis (MS), with an estimated point prevalence of 30 to 60%. The lifetime prevalence may be closer to 50 to 75%, as cognitive symptoms tend to progress with disease progression. Unfortunately, cognitive dysfunction can also be one of the more disabling symptoms of MS (13). This chapter reviews the prevalence, diagnosis, possible etiologies, assessment, and treatment of cognitive disorders in MS.

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References

  1. Amato MP, Ponziani G, Siracusa G, Sorbi S. Cognitive dysfunction in early-onset multiple sclerosis: a reappraisal after 10 years. Arch Neurol 2001;58:1602–1606.

    Article  PubMed  CAS  Google Scholar 

  2. Rao SM, Leo GJ, Bernardin L, Unverzagt F. Cognitive dysfunction in multiple sclerosis. I. Frequency, patterns, and prediction. Neurology 1991;41:685–691.

    PubMed  CAS  Google Scholar 

  3. Rao SM, Leo GJ, Ellington L, Nauertz T, Bernardin L, Unverzagt F. Cognitive dysfunction in multiple sclerosis II. Impact on employment and social functioning. Neurology 1991;41:692–696.

    PubMed  CAS  Google Scholar 

  4. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (4th ed). American Psychiatric Association, Washington, DC, 1994.

    Google Scholar 

  5. Rao S. Neuropsychology of multiple sclerosis: a critical review. J Clin Exp Neuropsychol 1986;8:503–542.

    PubMed  CAS  Google Scholar 

  6. Beatty WW, Goodkin DE, Monson N, Beatty P. Cognitive disturbances in patients with relapsing remitting multiple sclerosis. Arch Neurol 1989;46:1113–1119.

    PubMed  CAS  Google Scholar 

  7. Thornton AE, Raz N. Memory impairment in multiple sclerosis: a quantitative review. Neuropsychology 1997;11:357–366.

    Article  PubMed  CAS  Google Scholar 

  8. Zakzanis K. Distinct neurocognitive profiles in multiple sclerosis subtypes. Arch Clin Neuropsychol 2000;15:115–136.

    Article  PubMed  CAS  Google Scholar 

  9. Kujala P, Portin R, Ruutianen J, Memory deficits and early cognitive deterioration in MS. Acta Neurologica Scand 1996;93:329–335.

    Article  CAS  Google Scholar 

  10. Kail R. Speed of information processing in patients with Multiple Sclerosis. J Clin Exper Neuropsychol 1998;20:1–9.

    Article  Google Scholar 

  11. Grant I, McDonald WI, Trimble M. Neuropsychological impairment in early multiple sclerosis. In: Jensen K, et al. eds. Mental Disorders and Cognitive Deficits in Multiple Sclerosis John Libbey, London, 1989, pp. 17–26.

    Google Scholar 

  12. Brassington JC, Marsh NV. Neuropsychological aspects of multiple sclerosis. Neuropsychol Rev 1998;8:43–77.

    Article  PubMed  CAS  Google Scholar 

  13. Basso MR, Beason-Hazan S, Lynn J, Rammochan K, Bornstein RA. Screening for cognitive dysfunction in multiple sclerosis. Arch Neurol 1996;53:980–984.

    PubMed  CAS  Google Scholar 

  14. Rovaris M, Fillippi M, Falautano M, et al. Relation between MR abnormalities and patterns of cognitive impairment in multiple sclerosis. Neurology 1998;50:1601–1608.

    PubMed  CAS  Google Scholar 

  15. DeLuca J, Barbieri-Berger S, Johnson SK. The nature of memory impairments in multiple sclerosis: acquisition versus retrieval. J Clin Exp Neuropsychol 1994;16:183–189.

    PubMed  CAS  Google Scholar 

  16. Beatty W, Monson N. Picture and motor sequencing in Multiple Sclerosis. J Clin Exp Neuropsychol 1994;16:165–172.

    PubMed  CAS  Google Scholar 

  17. Foong J, et al. Executive function in multiple sclerosis: the role of frontal lobe pathology. Brain 1997;120:15–26.

    Article  PubMed  Google Scholar 

  18. Zivadinov R, De Masi R, NaSuelli D, et al. MRI techniques and cognitive impairment in the early phase of relapsing-remitting multiple sclerosis. Neuroradiology 2001;43:272–278.

    Article  PubMed  CAS  Google Scholar 

  19. Achiron A, Barak Y. Cognitive impairment in probable multiple sclerosis. J Neurol Neurosurg Psychiatry, 2003;74:443–446.

    Article  PubMed  CAS  Google Scholar 

  20. Amato M, Ponziani G, Siracusa G, Sorbi S. Cognitive dysfunction in early-onset multiple sclerosis: a reappraisal after 10 years. Arch Neurol 2001;58:1602–1606.

    Article  PubMed  CAS  Google Scholar 

  21. LaRocca, N.G., Personal Communication. 2001.

    Google Scholar 

  22. Camp S, Stevenson V, Thompson A, et al. Cognitive function in primary progressive and transitional progressive multiple sclerosis: a controlled study with MRI correlates. Brain 1999;122:1341–1348.

    Article  PubMed  Google Scholar 

  23. Comi G, Fillipi M, Marinelli V, et al. Brain MRI correlates of cognitive impairment in primary and secondary progressive multiple sclerosis. J Neurol Sci, 1995;132:222–227.

    Article  PubMed  CAS  Google Scholar 

  24. Hohol MJ, Guttman CRG, Orav J, et al. Serial neuropsychological assessment and magnetic resonance imaging analysis in multiple sclerosis. Arch Neurol 1997;54:1018–1025.

    PubMed  CAS  Google Scholar 

  25. Sperling RA, Guttman CR, Hohol MJ, et al. Regional magnetic resonance imaging lesion burden and cognitive functioning in multiple sclerosis: a longitudinal study. Arch Neurol 2001;58:115–121.

    Article  PubMed  CAS  Google Scholar 

  26. van Buchem MA, McGowan JC, Gossmann RI. Magnetization transfer histogram methodology: its clinical and neuropsychological correlates. Neurology 1999;53(S3):S23–S28.

    PubMed  Google Scholar 

  27. Rovaris M, Filippi M, Minicucci L, et al. Cortical/subcortical disease burden and cognitive impairment in patients with multiple sclerosis. AJNR Am J Neuroradiol 2000;21:402–408.

    PubMed  CAS  Google Scholar 

  28. Rovaris M, Filippi M. MRI correlates of cognitive dysfunction in multiple sclerosis patients. J Neurovirol 2000;6(Suppl 2):S172–S175.

    PubMed  Google Scholar 

  29. Foong J, Rozewicz L, Bavieca, Thompson AJ, Miller DH, Ron MA, et al. Correlates of executive function in multiple sclerosis: the use of magnetic resonance spectroscopy as an index of focal pathology. J Neuropsychiat Clin Neurosci 1999;11:54–50.

    Google Scholar 

  30. Krupp LB, Alvarez LA, LaRocca NG, Scheinberg LC, et al. Fatigue in multiple sclerosis. Arch Neurol 1988;45:435–437.

    PubMed  CAS  Google Scholar 

  31. Krupp LB, Sliwinski M, Masur DM, Friedberg F, Coyle PK, et al. Cognitive functioning and depression in patients with chronic fatigue syndrome and multiple sclerosis. Arch Neurol 1994;51:705–710.

    PubMed  CAS  Google Scholar 

  32. Krupp LB, Elkins LE. Fatigue and declines in cognitive functioning in multiple sclerosis. Neurology 2000;55:934–939.

    PubMed  CAS  Google Scholar 

  33. Canellopoulou M, Richardson JTE. The role of executive function in imagery mnemonics: evidence from multiple sclerosis. Neuropsychologia 1998;36:1181–1188.

    Article  PubMed  CAS  Google Scholar 

  34. Zivadinov R, Sepcic J, Nasuelli D, et al. A longitudinal study of brain atrophy and cognitive disturbances in the early phase of relapsing-remitting multiple sclerosis. J Neurol Neurosurg Psychiatry 2001;70:773–780.

    Article  PubMed  CAS  Google Scholar 

  35. Edwards S, Liu C, Blumhardt L. Cognitive correlates of supratentorial atrophy on MRI in multiple sclerosis. Acta Neurologica Scand 2001;104:214–223.

    Article  CAS  Google Scholar 

  36. Benedict R, Bakshi R, Simon JH, Priore R, Miller C, Munschauer F, et al. Frontal cortex atrophy predicts cognitive impairment in multiple sclerosis. J Neuropsychiatry Clin Neurosci 2002;14:44–51.

    PubMed  Google Scholar 

  37. Huber SJ, Rammohan KW, Bornstein RA, Christy JA, et al. Depressive symptoms are not influenced by severity of multiple sclerosis. Neuropsychiatry Neuropsychol Behav Neurol 1993;6:177–180.

    Google Scholar 

  38. Staffen W, Mair A, Zauner H, et al. Cognitive function and fMRI in patients with multiple sclerosis: evidence for compensatory cortical activation during an attention task. Brain 2002;125:1275–1282.

    Article  PubMed  CAS  Google Scholar 

  39. Gilchrist AC, Creed FH. Depression, cognitive impairment and social stress in multiple sclerosis. J Psychosomat Med 1994;38:193–201.

    Article  CAS  Google Scholar 

  40. Mohr DC, Goodkin DE, Gatto N, Van Der Wende J, et al. Depression, coping, and level of neurological impairment in multiple sclerosis. Mult Scler 1997;3:254–258.

    Article  PubMed  CAS  Google Scholar 

  41. Arnett PA, Higgenson CI, Randolph JJ. Depression in multiple sclerosis: relationship to planning ability. J Intl Neuropsychol Soc 2001;7:665–674.

    Article  CAS  Google Scholar 

  42. Baddeley AD, Hitch GJ. Working memory. In: The Psychology of Learning and Motivation, Bower GH, ed. Academic Press, San Diego, 1974, pp. 47–90.

    Google Scholar 

  43. Arnett PA, Higginson CI, Voss ND, et al. Depressed mood in multiple sclerosis: relationship to capacity-demanding memory and attentional functioning. Neuropsychology 1999;13:434–446.

    Article  PubMed  CAS  Google Scholar 

  44. Thornton AE, Raz N. Memory impairment in multiple sclerosis: a quantitative review. Neuropsychology, 1997;11:357–366.

    Article  PubMed  CAS  Google Scholar 

  45. Arnett PA, Higginson CI, Voss WD, Bender WI, Wurst JM, Tippin JM. Depression in multiple sclerosis: relationship to working memory capacity. Neuropsychology 1999;13:546–556.

    Article  PubMed  CAS  Google Scholar 

  46. Arnett PA, Higginson CT, Voss WD, et al. Depressed mood in multiple sclerosis: relationship to capacity-demanding memory and attentional functioning. Neuropsychology 1999;13:434–446.

    Article  PubMed  CAS  Google Scholar 

  47. Benedict R, Fischer JS, Archibald CJ, et al. Minimal neuropsychological assessment of MS patients: a consensus approach. Clin Neuropsychologist 2002;16:381–397.

    Google Scholar 

  48. Benedict R, et al. Screening for multiple sclerosis cognitive impairment using a self-administered 15-item questionnaire. Mult Scler 2003;9:95–101.

    Article  PubMed  CAS  Google Scholar 

  49. Rao SM. Neuropsychology Screening Battery for Multiple Sclerosis [unpublished manuscript]. Medical College of Wisconsin, Milwaukee, WI.

    Google Scholar 

  50. Fischer JS, Priore RL, Jacobs LD, et al., Neuropsychological effects of interferon beta-1a in relapsing multiple sclerosis. Multiple Sclerosis Collaborative Research Group. Ann Neurol 2000;48:885–892.

    Article  PubMed  CAS  Google Scholar 

  51. Pliskin NH, Hamer DP, Goldstein DS, et al. Improved delayed visual reproduction test performance in multiple sclerosis patients receiving interferon beta-1b. Neurology 1996;47:1463–1468.

    PubMed  CAS  Google Scholar 

  52. Weinstein A, Schwid SI, Schiffer RB, McDermott MP, Giang DW, Goodman AD. Neuropsychologic status in multiple sclerosis after treatment with glatiramer. Arch Neurol 1999;56:319–324.

    Article  PubMed  CAS  Google Scholar 

  53. Greene Y, Tariot P, Wishart H, et al. 12-week, open trial of donepezil hydrochloride in patients with multiple sclerosis and associated cognitive impairments. J Clin Psychopharmacol 2000;20:350–356.

    Article  PubMed  CAS  Google Scholar 

  54. Jønsson A, Korfitzen EM, Heltberg A, Ravnborg MH, Byskov-Ottosen E. Effects of neuropsychological treatment in patients with multiple sclerosis. Acta Neurologica Scand 1993;88:394–400.

    Google Scholar 

  55. Plohmann AM, Kappos L, Ammann W, et al. Computer assisted retraining of attentional impairments in patients with multiple sclerosis. J Neurol Neurosurg Psychiatry 1998;64:455–462.

    Article  PubMed  CAS  Google Scholar 

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© 2005 Humana Press Inc., Totowa, NJ

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Cox, D., Julian, L. (2005). Cognitive Dysfunction in Multiple Sclerosis. In: Olek, M.J. (eds) Multiple Sclerosis. Current Clinical Neurology. Humana Press. https://doi.org/10.1385/1-59259-855-2:091

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  • DOI: https://doi.org/10.1385/1-59259-855-2:091

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-033-5

  • Online ISBN: 978-1-59259-855-7

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