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Proapoptotic Gene Silencing Via Methylation in Human Tumors

  • Chapter
Death Receptors in Cancer Therapy

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Abstract

Apoptosis, or programmed cell death (PCD), is an active process whereby individual cells, responding to internal and/or external stimuli, commit suicide. This process plays a crucial role in the normal life cycle of organisms, facilitating embryonic development, metamorphosis, cellular specialization; maintaining homeostasis (1,2). Apoptosis is characterized by a complex set of tightly controlled biochemical and molecular events leading to cell death, disassembly of various cellular components, and eventual engulfment of the resulting cellular debris (3,4). Inappropriate apoptosis has been associated with a variety of pathological conditions, such as neurodegenerative disorders, autoimmune phenomena, mitochondrial disorders, ischemic damage and cancer (5,6).

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Authors and Affiliations

  1. Department of Hematology and Oncology, St. Jude Children’s Research Hospital, Memphis, TN

    Tanya Tekautz MD

  2. Department of Genetics and Tumor Cell Biology, St. Jude Children’s Research Hospital, Memphis, TN

    Tanya Tekautz MD, Tal Teitz PhD, Jill M. Lahti PhD & Vincent J. Kidd PhD

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  2. Tal Teitz PhD
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Editors and Affiliations

  1. Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA

    Wafik S. El-Deiry MD, PhD

  2. Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA

    Wafik S. El-Deiry MD, PhD

  3. Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA

    Wafik S. El-Deiry MD, PhD

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Tekautz, T., Teitz, T., Lahti, J.M., Kidd, V.J. (2005). Proapoptotic Gene Silencing Via Methylation in Human Tumors. In: El-Deiry, W.S. (eds) Death Receptors in Cancer Therapy. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1385/1-59259-851-X:207

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  • DOI: https://doi.org/10.1385/1-59259-851-X:207

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