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Mammalian Cell Death Pathways

Intrinsic and Extrinsic

  • Chapter
Death Receptors in Cancer Therapy

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

Programmed cell death results from a conserved cascade of events essential in the development and maintenance of tissue homeostasis. “Extrinsic” cell-death pathways initiate at the cell surface, leading to execution through substrate cleavage, and may involve mitochondrial amplification. Multiple “intrinsic” death pathways converge and require signaling through the mitochondria. Extrinsic cell death is integral to cell-mediated immunity and host immune surveillance/suppression of cancer. Caspase activation is highly regulated and defects at virtually all levels of death regulation are observed in cancer. This chapter focuses on the cell biology, biochemistry, and genetics of programmed cell death.

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Authors and Affiliations

  1. Laboratory of Molecular Oncology and Cycle Cell Regulation, Howard Hughes Medical Institute, Chevy Chase, MD

    E. Robert McDonald III PhD

  2. Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA

    Wafik S. El-Deiry MD, PhD

  3. Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA

    Wafik S. El-Deiry MD, PhD

  4. Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA

    Wafik S. El-Deiry MD, PhD

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  1. E. Robert McDonald III PhD
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Editors and Affiliations

  1. Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA

    Wafik S. El-Deiry MD, PhD

  2. Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA

    Wafik S. El-Deiry MD, PhD

  3. Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA

    Wafik S. El-Deiry MD, PhD

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McDonald, E.R., El-Deiry, W.S. (2005). Mammalian Cell Death Pathways. In: El-Deiry, W.S. (eds) Death Receptors in Cancer Therapy. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1385/1-59259-851-X:001

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  • DOI: https://doi.org/10.1385/1-59259-851-X:001

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