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Biology of Brain Metastasis

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Book cover Brain Tumors

Part of the book series: Contemporary Cancer Research ((CCR))

Abstract

Brain metastases, which develop in up to 35% of all cancer patients, are a major cause of death from cancer. Development of improved therapies requires the understanding of the biology of brain metastasis. A relevant in vivo model for brain metastasis is essential. The intracarotid injection of murine or human cancer cells into syngeneic or immune-incompetent mice produces metastasis in different regions of the brain. This site-specific metastasis is not due to patterns of initial cell arrest, motility, or invasiveness, but rather to the ability of tumor cells to proliferate in the brain parenchyma or the meninges. The blood-brain barrier is intact in metastases that are smaller than 0.25 mm in diameter. Although in larger metastases the blood-brain barrier is leaky, the lesions are resistant to many chemotherapeutic drugs. These data demonstrate that the development of brain metastasis represents the end result of multiple interactions between tumor cells and the unique microenvironment of the brain.

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Authors and Affiliations

  1. Department of Cancer Biology, The University of Texas M. D. Anderson Cancer Center, Houston, TX

    Minsoo Kang MD, Takamitsu Fujimaki MD, DMSC, Seiji Yano MD, PhD & Isaiah J. Fidler DVM, PhD

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  1. Minsoo Kang MD
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  2. Takamitsu Fujimaki MD, DMSC
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  3. Seiji Yano MD, PhD
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  4. Isaiah J. Fidler DVM, PhD
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  1. Department of Surgery, Duke University Medical Center, Durham, NC

    Francis Ali-Osman DSc

  2. Comprehensive Cancer Center, Duke University Medical Center, Durham, NC

    Francis Ali-Osman DSc

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Kang, M., Fujimaki, T., Yano, S., Fidler, I.J. (2005). Biology of Brain Metastasis. In: Ali-Osman, F. (eds) Brain Tumors. Contemporary Cancer Research. Humana Press. https://doi.org/10.1385/1-59259-843-9:091

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