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Genetics of Atypical Parkinsonism

Implications for Nosology

  • Chapter
Atypical Parkinsonian Disorders

Part of the book series: Current Clinical Neurology ((CCNEU))

Abstract

Parkinson’s disease (PD) is traditionally defined as a clinico-pathologic entity, characterized by a core syndrome of akinesia, rigidity, tremor, and postural instability, and pathologically by a more or less selective degeneration of dopaminergic neurons of the substantia nigra, leading to a deficiency of dopamine in the striatal projection areas of these neurons. Characteristic eosinophilic inclusions, the Lewy bodies (LBs), are found in surviving dopaminergic neurons but also, although less abundantly, in other parts of the brain in most cases (1).

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Authors and Affiliations

  1. Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany

    Thomas Gasser MD

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  1. Thomas Gasser MD
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Editors and Affiliations

  1. Movement Disorder Program, Department of Neurology, University of Louisville School of Medicine, Louisville, KY

    Irene Litvan MD (Raymond Lee Lebby Professor of Parkinson Disease Research, Director) (Raymond Lee Lebby Professor of Parkinson Disease Research, Director)

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© 2005 Humana Press Inc., Totowa, NJ

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Gasser, T. (2005). Genetics of Atypical Parkinsonism. In: Litvan, I. (eds) Atypical Parkinsonian Disorders. Current Clinical Neurology. Humana Press. https://doi.org/10.1385/1-59259-834-X:139

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  • DOI: https://doi.org/10.1385/1-59259-834-X:139

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-331-2

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