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Atypical Parkinsonian Disorders pp 33–63Cite as

Neuropathology of Atypical Parkinsonian Disorders

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Part of the book series: Current Clinical Neurology ((CCNEU))

Abstract

Although the clinical syndrome of parkinsonism (rigidity, bradykinesia, and tremor) is most often owing to idiopathic Parkinson’s disease (PD), it may also be associated with a variety of other underlying pathologies (Table 1) (1–3). Each of these other pathological conditions tends to have a characteristic clinical phenotype, however atypical cases are increasingly recognized (4–8). Moreover, some patients with PD have additional clinical features such as dementia, autonomic dysfunction, or gastrointestinal dysmotility (9–13). As a result, the accurate diagnosis of a patient with parkinsonism, and especially those with atypical or additional clinical features, ultimately depends on neuropathological examination. This chapter will review the pathological changes that characterize those conditions that may present with or have parkinsonism as a major feature, either in isolation or combined with other clinical manifestations. Although the focus of this text and chapter are the atypical causes of parkinsonism, a description of the pathological features of typical PD is included for comparison.

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada

    Ian R. A. Mackenzie MD, FRCPC

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  1. Movement Disorder Program, Department of Neurology, University of Louisville School of Medicine, Louisville, KY

    Irene Litvan MD (Raymond Lee Lebby Professor of Parkinson Disease Research, Director) (Raymond Lee Lebby Professor of Parkinson Disease Research, Director)

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Mackenzie, I.R.A. (2005). Neuropathology of Atypical Parkinsonian Disorders. In: Litvan, I. (eds) Atypical Parkinsonian Disorders. Current Clinical Neurology. Humana Press. https://doi.org/10.1385/1-59259-834-X:033

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