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Instrumentation in the Cytogenetics Laboratory

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The Principles of Clinical Cytogenetics
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Abstract

Ask anyone to envision a typical clinical laboratory, and a host of blinking, whirring, computer-controlled machines that analyze samples and spit out results usually comes to mind. Even traditionally labor-intensive settings, such as the cytology laboratory are frequently populated by automatic stainers, and machines that prepare and automatically analyze pap smears are becoming ever more popular.

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References

  1. Spurbeck, J.L., Zinmeister, A.R., Meyer, K.J., and Jalal, S.M. (1996) Dynamics of chromosome spreading. Am. J. Med. Genet. 61, 387–393.

    Article  CAS  PubMed  Google Scholar 

  2. Drent P. (2003) Digital imaging—new opportunities for microscopy. Retrieved May 27, 2003 Nikon Microscopy, http://www.microscopyu.com/articles/photomicrography/digital/drentdigital.html (accessed May 27, 2003).

  3. US Department of Health and Human Services (2003) Fact sheet:rotecting the privacy of patients’ health information, http://www.hhs.gov/news/facts/privacy.html (accessed October 10, 2003).

  4. Gee S. (2001) Seeing the genome, part 1. Cytogenetics—the challenges for automated genetic image analysis systems. G.I.T. Imaging Microsc. 1, 4–7.

    Google Scholar 

  5. Gee S. (2001) Seeing the genome, part 2. Cytogenetics in colour—automated imaging systems for fluorescent in situ hybridization (FISH). G.I.T. Imaging Microsc. 3, 4–7.

    Google Scholar 

  6. Brenner M. and Dunlay T. (n.d.) Fluorescence in situ hybridization: hardware and software implications in the research laboratory. Nikon Microscopy, http://www.microscopyu.com/articles/fluorescence/insitu/brennerinsitu.html (accessed May 22, 2003).

  7. Speicher M.R., Gwyn Ballard S., and Ward D.C. (1996) Karyotyping human chromosomes by combinatorial multifluor FISH. Nature Genet. 12, 368–375.

    Article  CAS  PubMed  Google Scholar 

  8. Azofeifa J., Fauth C., Kraus J., et al. (2000) An optimized probe set for the detection of small interchromosomal aberrations by use of 24-color FISH. Am. J. Hum. Genet. 66, 1684–1688.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  9. Kirchoff M., Gerdes T., Maahr J., et al. (1999) Deletions below 10 megabasepairs are detected in comparative genomic hybridization by standard reference intervals. Genes Chromosomes Cancer 25, 410–413.

    Article  Google Scholar 

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© 2005 Humana Press Inc., Totowa, NJ

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Gersen, S.L., Downey, L. (2005). Instrumentation in the Cytogenetics Laboratory. In: Gersen, S.L., Keagle, M.B. (eds) The Principles of Clinical Cytogenetics. Humana Press, Totowa, NJ. https://doi.org/10.1385/1-59259-833-1:113

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