Skip to main content
SpringerLink
Log in

Emerging Research and Practices Regarding Nutrition, Diet, and Oral Medicine

  • Chapter
Nutrition and Oral Medicine

Part of the book series: Nutrition and Health ((NH))

  • 1233 Accesses

Abstract

The field of nutrition had its early heyday in the first half of the 20th century, only to be superseded by the rapidly growing fields of biochemistry, molecular biology, immunology, and genomics in the latter part of the century. At the present time, questions are once again being asked about nutrients, but this time they are being directed toward genomics, proteomics, cell signaling, developmental biology, cancer biology, tissue engineering, and much more. Like much of science, the questions relating nutrition to specific states of health and disease that have not yet been defined are the most intriguing. The aim of this chapter, therefore, is to guide the reader to areas of uncertainty and to leave the development of new approaches to defining the nutrition—disease relationship to the imagination and genius of the student, scientist, clinical practitioner, or entrepreneur.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Fomon SJ, Ekstrand J, Ziegler EE. Fluoride intake and prevalence of dental fluorosis: trends in fluoride intake with special attention to infants. J Public Health Dent 2000; 60:131–139.

    Article  CAS  Google Scholar 

  2. Alvarez JO. Nutrition, tooth development, and dental caries. Am J Clin Nutr 1995; 61(Suppl.): 410S–416S.

    CAS  Google Scholar 

  3. Konig KG. Diet and oral health. Int Dent J 2000; 50:162–174.

    CAS  Google Scholar 

  4. Lingstrom P, van Houte J, Kashket S. Food starches and dental caries. Crit Rev Oral Biol Med 2000; 11:366–80.

    CAS  Google Scholar 

  5. Moynihan P. The British Nutrition Foundation Oral Task Force Report: issues relevant to dental health professionals. Br Dent J 2000; 188:308–312.

    Article  CAS  Google Scholar 

  6. Sheiham A. Dietary effects on dental disease. Public Health Nutr 2001; 4:569–591.

    CAS  Google Scholar 

  7. McNutt K. Sugar replacers and the FDA noncariogenicity claim. J Dent Hygiene 2000; 74:36–40

    CAS  Google Scholar 

  8. Soderling E. Summary Report: Nutrition, diet and oral health in the 21st century. Int Dent J 2001; 51:389–391.

    CAS  Google Scholar 

  9. Kashket S. Historical review of remineralization research. J Clin Dent 1999; 10:56–63.

    Google Scholar 

  10. Proceedings, Workshop on Technological Advances in Intra-oral Model Systems Used to Assess Cariogenicity. J Dent Res 1992; 71(Spec Issue):801–956.

    Google Scholar 

  11. Kashket S, DePaola DP. Cheese consumption and the development and progression of dental caries. Nutr Rev 2002; 60:97–103.

    Article  Google Scholar 

  12. Jensen ME, Wefel JS. Human plaque pH responses to meals and the effects of chewing gum. Br Dent J 1989; 167:204–208.

    Article  CAS  Google Scholar 

  13. Hall AF, Creanor SL, Strang R, et al. The effect of sucrose-containing chewing-gum use on in situ enamel lesion remineralization. Caries Res 1995; 29:477–482.

    Article  CAS  Google Scholar 

  14. Szoke J, Banoczy J, Proskin HM. Effect of after-meal sucrose-free gum-chewing on clinical caries. J Dent Res 2001; 80:1725–1729.

    CAS  Google Scholar 

  15. Machiulskiene V, Nyvad B, Baelum V. Caries preventive effect of sugar-substituted chewing gum. Community Dent Oral Epidemiol 2001; 29:278–288.

    Article  CAS  Google Scholar 

  16. Smith DJ. Dental caries vaccines: prospects and concerns. Crit Rev Oral Biol Med 2002; 13: 335–349.

    CAS  Google Scholar 

  17. Young CS, Vacanti JP, Terada S, Bartlett JD, Yelick PC. Immunohistochemical analyses of bioengineered tooth tissues. J Dent Res 2002; 81(Spec Issue A):A–146.

    Google Scholar 

  18. Enwonwu CO. Interface of malnutrition and periodontal diseases. Am J Clin Nutr 1995; 61(Suppl.): 430S–436S.

    CAS  Google Scholar 

  19. Munoz CS, Kiger RD, Stephens JA, Kim J, Wilson AC. Effects of a nutritional supplement on periodontal status. Compend Contin Educ Dent 2001; 22:425–428.

    CAS  Google Scholar 

  20. Enwonwu CO, Phillips RS, Falkler WA. Nutrition and oral infectious diseases: state of the science. Compend Contin Educ Dent 2002; 23:431–448.

    Google Scholar 

  21. Enwonwu CO. Cellular and molecular effects of malnutrition and their relevance to periodontal disease. J Clin Periodontol 1994; 21(10):643–657.

    Article  CAS  Google Scholar 

  22. Grimble, RF. Nutritional modulation of immune function. Proc Nutr Soc 2001; 60:389–397.

    CAS  Google Scholar 

  23. Wu T, Trevisan M, Genco RJ, Dorn JP, Falkner KL, Sempos CT. Periodontal disease and risk of cerebrovascular disease: the first national health and nutrition examination survey and its follow-up study. Arch Intern Med 2000; 160:2749–2755.

    Article  CAS  Google Scholar 

  24. Genco R, Offenbacher S, Beck J. Periodontal disease and cardiovascular disease: epidemiology and possible mechanisms. J Am Dent Assoc 2002; 133(Suppl.):14S–22S.

    Google Scholar 

  25. Glurich I, Grossi S, Albini B, et al. Systemic inflammation in cardiovascular and periodontal disease: comparative study. Clin Diag Lab Immunol 2002; 9:425–432.

    Article  Google Scholar 

  26. Joshipura K, Ritchie C, Douglass C. Strength of evidence linking oral conditions and systemic disease. Compend Contin Educ Dent 2000; 21(Suppl.):12–23.

    Google Scholar 

  27. Saito Tssimazaki Y, Koga T, Tsuzuki M, Oshima A. Relationship between upper body obesity and periodontitis. J Dent Res 2001; 80:1631–1636.

    Article  Google Scholar 

  28. Joshipura K. The relationship between oral conditions and ischemic stroke and peripheral vascular disease. J Am Dent Assoc 2002; 133(Suppl.):23S–30S.

    Google Scholar 

  29. Tsai C, Hayes C, Taylor GW. Glycemic control of type 2 diabetes and severe periodontal disease in the US adult population. Community Dent Oral Epidemiol 2002; 30:182–192.

    Article  Google Scholar 

  30. Grossi SG, Genco RJ. Periodontal disease and diabetes mellitus: a two-way relationship. Ann Periodontol 1998; 3:51–61.

    CAS  Google Scholar 

  31. Soskolne WA, Klinger A. The relationship between periodontal diseases and diabetes: an overview. Ann Periodontol 2001; 6:91–98.

    Article  CAS  Google Scholar 

  32. Salvi GE, Lawrence HP, Offenbacher S, Beck JD. Influence of risk factors on the pathogenesis of periodontitis. Periodontol 2000 1997; 14:173–201.

    Article  CAS  Google Scholar 

  33. Krall EA. The periodontal-systemic connection: implications for treatment of patients with osteoporosis and periodontal disease. Ann Periodontol 2002; 6:209–213.

    Article  Google Scholar 

  34. Nishida M, Grossi SG, Dunford RG, Ho AW, Trevisan M, Genco RJ. Calcium and the risk for periodontal disease. J Periodontol 2 0001; 71:1057–1066.

    Article  Google Scholar 

  35. Socransky SS, Haffajee AD, Cugini MA, Smith C, Kent RL Jr. Microbial complexes in subgingival plaque. J Clin Periodontol 1998; 25:134–144.

    Article  CAS  Google Scholar 

  36. Maiden MFJ, Pham C, Kashket S. Glucose toxicity effect and accumulation of methylglyoxal by the periodontal anaerobe Bacteroides forsythus. Anaerobe 2004; 10:27–32.

    Article  CAS  Google Scholar 

  37. Kashket S, Maiden M, Haffajee A, Kashket ER. Accumulation of methylglyoxal in the gingival crevicular fluid of chronic periodontitis patients. J Clin Periodontol 2003; 30:364–367.

    Article  CAS  Google Scholar 

  38. Lalla E, Lamster IB, Stern DM, Schmidt AM. Receptor for advanced glycation end products, inflammation, and accelerated periodontal disease in diabetes: mechanisms and insights into therapeutic modalities. Ann Periodontol 2001; 6:113–118.

    Article  CAS  Google Scholar 

  39. Heasman PA, Collins JG, Offenbacher S. Changes in crevicular fluid levels of interleukin-1 beta, leukotriene B4, prostaglandin E2, thomboxane B2 and tumour necrosis factor alpha in experimental gingivitis in humans. J Periodontol Res 1993; 28:241–247.

    Article  CAS  Google Scholar 

  40. Zhang J, Kashket S, Lingstrom P. Evidence for the early onset of gingival inflammation following short-term plaque accumulation. J Clin Periodontol 2003; 29:1082–1085; 30:278.

    Article  Google Scholar 

  41. Saito T, Shimazaki Y, Yamashita Y, Koga T, Tsuzuki M, Sakamoto M. Association between periodontitis and exercise capacity. Periodontal Insights 1999; 62:9–12.

    Google Scholar 

  42. Kopelman PG. Obesity as a medical problem. Nature 2000; 404:635–643.

    CAS  Google Scholar 

  43. Haffajee AD, Socransky SS, Carpino EA, Teles RP. Relation of BMI to periodontal, microbial and host parameters. J Dent Res 2004; 83(Spec Iss A)abstract 173.

    Google Scholar 

  44. Das UN. Is obesity an inflammatory condition? Nutrition 2001; 17:953–966.

    Article  CAS  Google Scholar 

  45. Gemmell E, Marshall RJ, Seymour GJ. Cytokines and prostaglandins in immune homeostasis and tissue destruction in periodontal disease. Periodontol 2000 1997; 14:112–143.

    Article  CAS  Google Scholar 

  46. Gemmell E, Marshall RJ, Seymour GJ. Cytokines and prostaglandins in immune homeostasis and tissue destruction in periodontal disease. Periodontol 2000 1997; 14:112–143.

    Article  CAS  Google Scholar 

  47. Averous J, Bruhat A, Mordier S, Fafournoux P. Recent advances in the understanding of amino acid regulation of gene expression. J Nutr 2003; 133(Suppl. 1):2040S–2045S.

    CAS  Google Scholar 

  48. Moore JB, Blanchard RK, Cousins RJ. Dietary zinc modulates gene expression in murine thymus: results from a comprehensive differential display screening. Proc Natl Acad Sci USA 2003; 100:3883–3888.

    Article  CAS  Google Scholar 

  49. Hesketh JE, Villette S. Intracellular trafficking of micronutrients from gene regulation to nutrient requirements. Proc Nutr Soc 2002; 61:405–414.

    Article  CAS  Google Scholar 

  50. Olson RE. Nutrition and genetics: an expanding frontier. Am J Clin Nutr 2003; 78:201–208.

    CAS  Google Scholar 

  51. Clark SD. Polyunsaturated fatty acid regulation of gene transcription: a mechanism to improve energy balance and insulin resistance. Br J Nutr 2000; 83(Suppl.):S59–S66.

    Google Scholar 

  52. Jump DB, Clark SD. Regulation of gene expression by dietary fat. Annu Rev Nutr 1999; 19:63–90.

    Article  CAS  Google Scholar 

  53. Loktionov A. Common gene polymorphisms and nutrition: emerging links with pathogenesis of multifactorial chronic diseases (review). J Nutr Biochem 2003; 14:426–451.

    Article  CAS  Google Scholar 

  54. Muller M, Kersten S. Nutrigenomics: goals and strategies. Nature Rev (Genetics) 2003; 4:315–322.

    Article  CAS  Google Scholar 

  55. Battino M, Bullon P, Wilson M, Newman H. Oxidative injury and inflammatory periodontal diseases: the challenge of anti-oxidants to free radicals and reactive oxygen species. Crit Rev Oral Biol Med 1999; 10:458–476.

    CAS  Google Scholar 

  56. Bravo L. Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. Nutr Rev 1998; 56:317–333.

    Article  CAS  Google Scholar 

  57. Waddington RJ, Moseley R, Embery G. Reactive oxygen species: a potential role in the pathogenesis of periodontal diseases. Oral Dis 2000; 6:136–137.

    Google Scholar 

  58. Sculley DV, Langley-Evans SC. Salivary antioxidants and periodontal disease status. Proc Nutr Soc 2002; 61:137–143.

    Google Scholar 

  59. Diab-Ladki R, Pellat B, Chahine R. Decrease in the total antioxidant activity of saliva in patients with periodontal diseases. Clin Oral Investig 2003; 7:103–107.

    Article  Google Scholar 

  60. Zhang J, Kashket S. Inhibition of salivary amylase by black and green teas and their effects on the intraoral hydrolysis of starch. Caries Res 1998; 32:233–238.

    Article  CAS  Google Scholar 

  61. Paolino VJ, Kashket S. Inhibition by cocoa extracts of biosynthesis of extracellular polysaccharides by human oral bacteria. Arch Oral Biol 1985; 30:359–363.

    Article  CAS  Google Scholar 

  62. Hattori M, Kusumoto IT, Namba T, Ishigami T, Hara Y. Effect of tea polyphenols on glucan synthesis by glucosyltransferase from Streptococcus mutans. Chem Pharm Bull (Tokyo) 1990; 38:717–720.

    CAS  Google Scholar 

  63. Hara Y. Antioxidative action of tea polyphenols. 1. Am Biotechnol Lab 1994; 12:48.

    CAS  Google Scholar 

  64. Wu CD, Wei GX. Tea as a functional food for oral health. Nutrition 2002; 18:443–444.

    Article  CAS  Google Scholar 

  65. Hwang BY, Roberts SK, Chadwick LR, Wu CD, Kinghorn A. Antimicrobial constituents from goldenseal (the rhizomes of Hydrastis canadensis) against select oral pathogens. Planta Med 2003; 69:623–627.

    Article  CAS  Google Scholar 

  66. Ho KY, Tsai CC, Huang JS, Chen CP, Lin TC, Lin CC. Antimicrobial activity of tannin components from Vaccinium vitis-idaea L. J Pharm Pharmacol 2001; 53:187–191.

    Article  CAS  Google Scholar 

  67. Mao TK, Van der Water J, Keen CL, Schmitz HH, Geshwind ME. Effect of flavonols and their related oligomers on the secretin of interleukin-5 in peripheral blood mononuclear cells. J Med Food 2002; 5:17–22.

    Article  CAS  Google Scholar 

  68. Song SE, Choi BK, Kim SN, et al. Inhibitory effect of procyanidin oligomer from elm cortex on the matrix metalloproteinases and proteases of periodontopathogens. J Periodontal Res 2003; 38:282–289.

    Article  CAS  Google Scholar 

  69. Hirasawa M, Takada K, Makimura M, Otake S. Improvement of periodontal status by green tea catechin using a local delivery system: a clinical pilot study. J Periodontal Res 2002; 37:433–438.

    Article  CAS  Google Scholar 

  70. Nishida M, Grossi SG, Dunford RG, Ho AW, Trevisan M, Genco RJ. Dietary vitamin C and the risk for periodontal disease. J Periodontol 2000b; 71:1215–1223.

    Article  CAS  Google Scholar 

  71. Neiva RF, Steigenga J, Al-Shammari KF, Wang HL. Effects of specific nutrients on periodontal disease onset, progression and treatment. J Clin Periodontol 2003; 30:579–589.

    Article  CAS  Google Scholar 

  72. Shinkai RS, Hatch JP, Sakai S, Mobley CC, Saunders MJ, Rugh JD. Oral functions and diet quality in a community-based sample. J Dent Res 2001; 80:1625–1630.

    CAS  Google Scholar 

  73. Walls AW, Steele JG, Sheiham A, Marcenes W, Moynihan PJ. Oral health and nutrition in older people. J Public Health Dent 2000; 60:304–307.

    Article  CAS  Google Scholar 

  74. Sheiham A, Steele JG, Marcenes W, et al. The relationship among dental status, nutrient intake, and nutritional status in older people. J Dent Res 2001; 80:408–413.

    CAS  Google Scholar 

  75. Moynihan P, Bradbury J. Compromised dental function and nutrition. Nutrition 2001; 17:177–178.

    Article  CAS  Google Scholar 

  76. Ritchie CS, Joshipura K, Hung HC, Douglass CW. Nutrition as a mediator in the relation between oral and systemic disease: associations between specific measures of adult oral health and nutrition outcomes. Crit Rev Oral Biol Med 2002; 13:291–300.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Forsyth Institute, Boston, MA

    Shelby Kashket PhD & Dominick P. DePaola DDS, PhD (CEO)

Authors
  1. Shelby Kashket PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dominick P. DePaola DDS, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Primary Care, School of Health-Related Professions, University of Medicine and Dentistry of New Jersey, Newark, NJ

    Riva Touger-Decker PhD, RD, FADA

  2. Department of Diagnostic Sciences, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark, NJ

    Riva Touger-Decker PhD, RD, FADA

  3. Department of Oral Medicine, New York University College of Dentistry, New York, NY

    David A. Sirois DMD, PhD

  4. Department of Professional Studies, University of Nevada Las Vegas School of Dental Medicine, Las Vegas, NV

    Connie C. Mobley PhD, RD

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Humana Press Inc., Totowa, NJ

About this chapter

Cite this chapter

Kashket, S., DePaola, D.P. (2005). Emerging Research and Practices Regarding Nutrition, Diet, and Oral Medicine. In: Touger-Decker, R., Sirois, D.A., Mobley, C.C. (eds) Nutrition and Oral Medicine. Nutrition and Health. Humana Press. https://doi.org/10.1385/1-59259-831-5:167

Download citation

  • DOI: https://doi.org/10.1385/1-59259-831-5:167

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-192-9

  • Online ISBN: 978-1-59259-831-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation