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Impacts and Interrelationships Between Medications, Nutrition, Diet, and Oral Health

  • Miriam R. Robbins
Part of the Nutrition and Health book series (NH)

Abstract

Long-term medication therapy is common, allowing increasing numbers of people to control chronic illnesses and achieve improved quality of life. However, use of medications is rarely without side effect or risk, making prevention and management of medication complications more challenging. As patients with chronic illness age, it is more common to encounter multiple medications directed at multiple organ systems, compounding the challenge of managing the adverse effects of, and interactions among, multiple medications. Drug-nutrient interactions and nutritional deficiencies are a potential primary problem with many medications, which can also lead to secondary oral health complications. Likewise, medications can affect primarily the oral environment and have secondary nutritional and diet consequences. This chapter reviews common drug-induced nutrient deficits and their mechanisms, drug-induced adverse oral conditions, and selected interrelationships between medications and nutritional and oral health.

Keywords

Oral Health Pernicious Anemia Folic Acid Deficiency Altered Taste Removable Dental Prosthesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Roe DA. Drug-Induced Nutritional Deficiencies, 2nd Ed. Westport, CT: Avi Publishing, 1985.Google Scholar
  2. 2.
    Rikans LE. Drugs and nutrition in old age. Life Sci 1986; 39(12):1027–1036.CrossRefGoogle Scholar
  3. 3.
    Branda R. Effects of drugs on cellular transport of nutrients. In Winick M, ed. Nutrition and Drugs. New York, NY: John Wiley, 1983, 13–29.Google Scholar
  4. 4.
    Lamy PP. Drug-nutrient interactions in the aged. In Watson RR, ed. Handbook of Nutrition in the Aged, 2nd Ed. Boca Raton, FL: CRC Press, 1994, 165–200.Google Scholar
  5. 5.
    Lamy ML. Drugs and oral health. The Maryland 1984; 60(7):125–135.Google Scholar
  6. 6.
    Blumberg J, Couris R. Pharmacology, nutrition and the elderly: interactions and implications. In Chernoff R, ed. Geriatric Nutrition: The Health Professionals Handbook. Gaithersburg, MD: Aspen Publishers, 1999L, 342–365.Google Scholar
  7. 7.
    Roe DA. Drugs, diet and nutrition. J Dent Children 1978; September-October:68–70.Google Scholar
  8. 8.
    Moseley V. Medications and malnutrition: cause and effect. J S C Med Assoc 1980; 76(7):339–342.Google Scholar
  9. 9.
    Zeman FJ. Drugs and Nutritional Care in Clinical Nutrition and Dietetics. Lexington, MA: D.C. Heath, 1983, 49–75.Google Scholar
  10. 10.
    Mohs ME. Assessment of nutritional status In Watson RR, ed. Handbook of Nutrition in the Aged, 2nd Ed. Boca Raton, FL: CRC Press, 1994, 145–164.Google Scholar
  11. 11.
    Roe DA. Drug-Induced Nutritional Deficiencies. In Roe DA, ed. Diet and Drug Interactions. Westport, CT: Avi Publishing, 1989, 83–103.Google Scholar
  12. 12.
    Dickerson JW. Some adverse effects of drugs on nutrition. Royal Soc Health J 1978; 98(6): 261–265.CrossRefGoogle Scholar
  13. 13.
    Zeman FJ Liver Disease and Alcoholism in Clinical Nutrition and Dietetics. Lexington, MA: D.C. Heath, 1983, 441–470.Google Scholar
  14. 14.
    Roe DA. Effects of drugs on nutrition. Life Sci 1974; 15(7):1219–1234.CrossRefGoogle Scholar
  15. 15.
    Roe DA. Medications and nutrition in the elderly. Primary Care 1994; 21:135–147.Google Scholar
  16. 16.
    Eddington ND. Pharmacokinetics. In Roberts J, Snyder DL, Friedman E, ed. Handbook of Pharmacology of Aging. Boca Raton, FL: CRC Press, 1996, 1–22.Google Scholar
  17. 17.
    Bressler R. Adverse drug reactions. In Bressler R, Katz MD, ed. Geriatric Pharmacology. New York, NY: McGraw-Hill, 1993, 41–61.Google Scholar
  18. 18.
    Roe DA. Drug-induced malnutrition in geriatric patients. Compr Ther 1977; 3(10):24–28.Google Scholar
  19. 19.
    Casciato DA. Supportive care. In Casciato DA, and Lowitz BB, ed. Manual of Clinical Oncology, 3rd Ed. Boston, MA: Little, Brown, 1996, 61–63.Google Scholar
  20. 20.
    Viswanathan CT, Welling, PG. Food effects on drug absorption. In Roe DA, ed. Drugs and Nutrition in the Geriatric Patient. New York, NY: Churchill Livingstone, 1984, 47–70.Google Scholar
  21. 21.
    Kirk KJ. Significant drug-nutrient interactions. Am Fam Phys 1995; 51:1175–1182.Google Scholar
  22. 22.
    Dresser GK, Bailey DG. Grapefruit juice-drug interactions. Clin Pharmacol Ther 2000; 68:28–34.CrossRefGoogle Scholar
  23. 23.
    Neuvonen PJ, Kivistoe KT. The clinical significance of food-drug interactions: a review. Med J Austral, 1989, 150:36–41.Google Scholar
  24. 24.
    Lambert ML. Drug and diet interactions. Am J Nurs 1975; 75(3):402–406.CrossRefGoogle Scholar
  25. 25.
    Roe DA. Interactions between drugs and nutrients. Med Clin North Am 1979; 63:998.Google Scholar
  26. 26.
    Holt GA. Food & Drug Interaction. Chicago, IL: Precept Press, 1998, 319–326.Google Scholar
  27. 27.
    Roe DA. Alcohol and the Diet. Westport, CT: Avi Publishing, 1979.Google Scholar
  28. 28.
    Roe DA. Drug-Induced Reactions to Alcohol and Food in Diet and Drug Interactions. Westport, CT: Avi Publishing, 1989, 59–71.Google Scholar
  29. 29.
    Lieber CS. Alcohol, protein nutrition and liver injury. In Winik M, ed. Nutrition and Drugs. New York, NY: Wiley-Interscience, 1983, 49–71.Google Scholar
  30. 30.
    Lewis IK, Hanlen JT, Hobbens MJ, Beck JD. Use of medications with potential oral adverse drug reactions. Special Care Dent 1993; 12(4):171–176CrossRefGoogle Scholar
  31. 31.
    Abdhollahi M, Radfar M. A review of drug-induced oral reactions. J Contemp Dent Prac 2003; 1: 10–31.Google Scholar
  32. 32.
    Lamy PP. Drugs, older adults and oral health. J Gerontol Nurs 1985; 11(10):36–37.Google Scholar
  33. 33.
    Soon JA. Effects of drug therapy on oral health of older adults. Can Dent Hygiene/Probe 1992; 3:(26):118–120.Google Scholar
  34. 34.
    Seymour RA. Oral and dental disorders. In Davies DM, Ferner RE, DeGlanville H, eds. Davies’s Textbook of Adverse Drug Reactions, 5th Ed. London, UK: Chapman & Hall Medical, 1998, 234–250.Google Scholar
  35. 35.
    Porte SR, Scully C. Adverse drug reactions in the mouth. Clin Dermatol 2000; 18(5):525–532.CrossRefGoogle Scholar
  36. 36.
    Guggenheimer J. Oral manifestations of drug therapy. Dent Clin North Am 2002; 46:857–868.CrossRefGoogle Scholar
  37. 37.
    Shiffman SS. Taste and smell losses in normal aging and disease. JAMA 1997; 278(16):1257–1362.Google Scholar
  38. 38.
    Henkin RI. Drug-induced taste and smell disorders. Drug Safety 1994; 11:318–377.Google Scholar
  39. 39.
    Frankmann CB. Medical nutrition therapy for neoplastic disease. In Mahan K, Escott-Stump S, eds. Krause’s Food, Nutrition and Diet Therapy, 10th Ed. Philadelphia, PA: WB Saunders, 2000, 867–888.Google Scholar
  40. 40.
    Wright JM. Oral manifestations of drug reactions. Dent Clin North Am 1984; 28(3):529–543.Google Scholar
  41. 41.
    Sonis ST. Oral complications of cancer therapy. In DeVita VT, Hellman S, Rosenberg SA, eds. Cancer: Principles and Practice of Oncology, 5th Ed. Philadelphia, PA: Lippincott-Raven, 1997, 2385–2393.Google Scholar
  42. 42.
    Korstanje MJ. Drug-induced mouth disorders. Clin Exp Dermatol 1995; 20(1):10–18.CrossRefGoogle Scholar
  43. 43.
    Duxbury AJ. Systemic pharmacotherapy. In Jones JH, Mason DK, eds. Oral Manifestations of Systemic Disease, 2nd Ed. London, UK: Bailliere Tindall, 1990, 411–479.Google Scholar
  44. 44.
    Linker CA. Folic acid deficiency. In Tierney LM, et al., eds. Current Medical Diagnosis and Treatment 2002, 41st Ed. New York, NY: Lange Medical/McGraw-Hill, 2002, 524–525.Google Scholar
  45. 45.
    Boyce HW Jr. Drug-induced esophageal damage: diseases of medical progress. Gastrointest Endosc 1998; 47:547–550.CrossRefGoogle Scholar
  46. 46.
    Kikendall JW. Pill-induced esophageal injury. In: Castell DO, Richter JE, eds. The Esophagus. Philadelphia, PA: Lippincott Williams & Wilkins, 1999.Google Scholar
  47. 47.
    Sliwa JA, Lis S. Drug-induced dysphagia. Arch Phys Med Rehabil. 1993; 74:445–447.Google Scholar
  48. 48.
    Balzer KM. Drug-induced dysphagia. Intl J MS Care 2000; 2(1):6.Google Scholar
  49. 49.
    U.S. Department of Health and Human Services. Harmful effects of medicines on the adult digestive system. NIH Publication No. 97-3421, September 1992.Google Scholar
  50. 50.
    Roe DA. Diet, nutrition and drug reactions. In Shils ME, Olson JA, Shike M, eds. Modern Nutrition in Health and Disease, 8th Ed. Philadelphia, PA: Lea and Febiger, 1994, 1399–1416.Google Scholar

Copyright information

© Humana Press Inc., Totowa, NJ 2005

Authors and Affiliations

  • Miriam R. Robbins
    • 1
  1. 1.Department of Oral MedicineNew York University College of DentistryNew York

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