Abstract
The presence of vascular dementia (VaD) is largely unrecognized and untreated in the elderly (1,2). The typical history is that of an elderly parent or grandparent who fails to regain the previous level of function and independence after a stroke. More often, in the absence of the heralding stroke symptoms, the family notices that the patient has become depressed and apathetic, exhibits personality changes, experiences social inhibition, and has slowing mental capacity and sluggish motor activities with the inability to solve simple daily problems. Walking becomes deliberate, insecure, with a shuffling character and short steps; patients become unsteady on their feet and may take frequent falls. Often, the patient also suffers from urinary urgency, stress incontinence, and nocturia. Patients are no longer able to perform simple activities of daily living (ADLs), such as using the bathroom, showering, getting dressed, cooking, shopping, participating in rehabilitation activities and exercise routines, or performing more complex tasks, such as using the telephone or balancing a checkbook. Frequently, these changes occur after a surgical procedure, such as abdominal surgery, knee or hip replacement, or coronary artery bypass graft (CABG).
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References
Román GC. Vascular dementia revisited: diagnosis, pathogenesis, treatment, and prevention. Med Clin N Am 2002;86:477–99.
Román GC, Erkinjuntti T, Wallin A, Pantoni L, Chui HC. Subcortical ischaemic vascular dementia. Lancet Neurol 2002;1:426–436.
Folstein MF, Folstein SE, McHugh PR. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189–198.
Huppert FA, Brayne C, Gill C, Paykel ES, Beardsall L. CAMCOG—a concise neuropsychological test to assist dementia diagnosis: sociodemographic characteristics in an elderly population sample. Br J Clin Psychol 1995;34:529–541.
Román GC, Royall DR. Executive control function: a rational basis for the diagnosis of vascular dementia. Alzheimer Dis Assoc Disord 1999;13(Suppl):S69–S80.
Dubois MF, Herbert R. The incidence of vascular dementia in Canada: a comparison with Europe and East Asia. Neuroepidemiology 2001;20:179–187.
Murray CJ, Lopez AD. Global mortality, disability, and the contribution of risk factors: global burden of disease study. Lancet 1997;349:1436–1442.
Román GC. Stroke, cognitive decline and vascular dementia: the silent epidemic of the 21st century. Neuroepidemiology 2003;22:161–164.
Erkinjuntti T, Gauthier S, eds. Vascular cognitive impairment. London, UK: Martin Dunitz, 2002.
Bowler JV, Hachinski V, eds. Vascular Cognitive Impairment: Preventable dementia. Oxford, UK: Oxford University Press, 2003.
Petersen RC, ed. Mild cognitive impairment: aging to Alzheimer’s disease. Oxford, UK: Oxford University Press, 2003.
Wentzel C, Rockwood K, MacKnight C, et al. Progression of impairment in patients with vascular cognitive impairment without dementia. Neurology 2001;57:714–716.
Ingles JL, Wentzel C, Fisk JD, Rockwood K. Neuropsychological predictors of incident dementia in patients with vascular cognitive impairment, without dementia. Stroke 2002;33:1999–2002.
O’Brien JT, Erkinjuntti T, Reisberg B, et al. Vascular cognitive impairment. Lancet Neurol 2003;2:89–98.
Polvikowski T, Sulkava R, Myllykangas L, et al. Prevalence of Alzheimer’s disease in very old people: a prospective neuropathological study. Neurology 2001;56:1690–1696.
Hénon H, Pasquier F, Durieu I, et al. Pre-existing dementia in stroke patients: baseline frequency, associated factors and outcome. Stroke 1997;28:2429–2436.
Hénon H, Durieu I, Guerouaou D, et al. Post-stroke dementia: incidence and relationship to pre-stroke cognitive decline. Neurology 2001;57:1216–1222.
Snowdon DA, Grenier LH, Mortimer JA, Riley KP, Markesbery WR. Brain infarction and the clinical expression of Alzheimer disease. The Nun study. J Am Med Assoc 1997;277:813–817.
Zekry D, Duyckaerts C, Belmin J, et al. The vascular lesions in vascular and mixed dementia: the weight of functional neuroanatomy. Neurobiol Aging 2003;24:213–219.
Zekry D, Duyckaerts C, Moulias R, et al. Degenerative and vascular lesions of the brain have synergistic effects in dementia of the elderly. Acta Neuropathol 2002;103:481–487.
Zekry D, Hauw J-J, Gold G. Mixed dementia: epidemiology, diagnosis, and treatment. JAGS 2002;50:1431–1438.
Goulding JM, Signorini DF, Chatterjee S, et al. Inverse relation between Braak stage and cerebrovascular pathology in Alzheimer predominant dementia. J Neurol Neurosurg Psychiatry 1999;67:654–657.
Longstreth WT Jr, Bernick C, Manolio T, et al. Lacunar infarcts defined by magnetic resonance imaging of 3660 elderly people: the Cardiovascular Health Study. Arch Neurol 1998;55:1217–1225.
Vermeer SE, Prins ND, den Heijer T, et al. Silent brain infarcts and the risk of dementia and cognitive decline. N Engl J Med 2003;348:1215–1222.
Rocca WA, Hofman A, Brayne C, et al. The prevalence of vascular dementia in Europe: facts and fragments from 1980-1990 studies. Ann Neurol 1991;30:817–824.
de la Torre JC. Alzheimer disease as a vascular disorder: nosological evidence. Stroke 2002;33:1152–1162.
Nolan KA, Lino MM, Seligmann AW, Blass JP. Absence of vascular dementia in an autopsy series from a dementia clinic. J Am Geriatr Soc 1998;46:567–604.
Barclay LL, Weiss EM, Mattis S, Bond O, Blass JP. Unrecognized cognitive impairment in cardiac rehabilitation patients. J Am Geriatr Soc 1988;36:22–28.
Abildstrom H, Rasmussen LS, Rentowl P, et al. Cognitive dysfunction 1–2 years after non-cardiac surgery in the elderly: International Study of Post-Operative Cognitive Dysfunction. Acta Anaesthesiol Scand 2000;44:1246–1251.
Pullicino P, Mifsud V, Wong E, Graham S, Ali I, Smajlovic D. Hypoperfusion-related cerebral ischemia and cardiac left ventricular systolic dysfunction. J Stroke Cerebrovasc Dis 2001;10:178–182.
McKhann GM, Goldsborough MA, Borowicz LM Jr, et al. Cognitive outcome after coronary artery bypass: a one-year prospective study. Ann Thorac Surgery 1997;63:510–515.
Newman MF, Kirchner JL, Phillips-Bute B, et al. Longitudinal assessment of neurocognitive function after coronary artery bypass surgery. N Engl J Med 2001;344:395–402.
Restrepo L, Wityk RJ, Grega MA, et al. Diffusion-and perfusion-weighted magnetic resonance imaging of the brain before and after coronary artery bypass graft surgery. Stroke 2002;33:2909–2915
Alexopoulos GS, Kiosses DN, Klimstra S, Kalayam B, Bruce ML. Clinical presentation of the ‘depression-executive dysfunction syndrome’ of late life. Am J Geriatr Psychiatry 2002;10:98–106.
Pugh KG, Lipsitz LA. The microvascular frontal-subcortical syndrome of aging. Neurobiol Aging 2002;23:421–431.
Verghese J, Lipton RB, Hall CB, et al. Abnormal gait as a predictor of non-Alzheimer’s dementia. N Engl J Med 2002;347:1761–1768.
Alexander GE, DeLong MR, Strick PL. Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Ann Rev Neurosci 1986;9:137–181.
Cummings JL. Frontal-subcortical circuits and human behavior. Arch Neurol 1993;50:873–880.
Mega MS, Cummings JL. Frontal-subcortical circuits and neuropsychiatric disorders. J Neuropsychiatry Clin Neurosci 1994;6:358–370.
Masterman DL, Cummings JL. Frontal-subcortical circuits: the anatomic basis of executive, social and motivated behaviors. J Psychopharmacol 1997;11:107–114.
Fuster JM. Executive frontal functions. Exp Brain Res 2000;133:66–70.
Royall DR, Lauterbach EC, Cummings JL, et al., and the Committee on Research of the American Neuropsychiatric Association. Executive Control Function: a review of its promise and challenges to clinical research. J Neuropsy Clin Neurosci 2002;14:377–405.
Luria AR. Higher Cortical Functions in Man. New York, NY: Basic Books, 1966.
Royall DR, Cordes JA, Polk M. CLOX: an executive drawing task. J Neurol Neurosurg Psychiatry 1998;64:588–594.
Reitan RM, Davidson LA. Clinical Neuropsychology: Current Status and Applications. Washington, DC: Hemisphere, 1974.
Teng EL, Chui HC. The Modified Mini-Mental State (3MS) examination. J Clin Psychiatry 1987;48:314–318.
Teng EL, Hasegawa K, Homma A, et al. The Cognitive Abilities Screening Instrument (CASI): a practical test for cross-cultural epidemiological studies of dementia. Int Psychogeriatr 1994;6:45–56.
Román GC. Vascular dementia today. Rev Neurol (Paris) 1999;155(Suppl):S64–S72.
Pohjasvaara T, Erkinjuntti T, Vataja R, Kaste M. Dementia three months after stroke. Baseline frequency and effect of different definitions of dementia in the Helsinki Stroke Aging Memory Study (SAM) cohort. Stroke 1997;28:785–792.
Tatemichi TK, Desmont DW, Paik M, et al. Clinical determinants of dementia related to stroke. Ann Neurol 1993;33:568–575.
Barba R, Martinez-Espinosa S, Rodriguez-Garcia E, Pondal M, Vivancos J, Del Ser T. Poststroke dementia: clinical features and risk factors. Stroke 2000;31:1494–501.
Leys D, Erkinjuntti T, Desmond DW, et al. Vascular dementia: the role of cerebral infarcts. Alzheimer Dis Assoc Disord 1999;13(Suppl):S38–S48.
Ferro JM. Hyperacute cognitive stroke syndromes. J Neurol 2001;248:841–849.
Roman GC, Tatemichi TK, Erkinjuntti T, et al. Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. Neurology 1993;43:250–60.
Desmond DW. Vascular dementia: a construct in evolution. Cerebrovasc Brain Metab Res 1996;8:296–325.
Delay J, Brion S. Les Démences Tardives. Paris, France: Masson et Cie, 1962.
Kopelman MD. Disorders of memory. Brain 2002;125:2152–2190.
Brandt T, Steinke W, Thie A, Pessin MS. Posterior cerebral artery territory infarcts: clinical features, infarct topography, causes and outcome. Multicenter results and a review of the literature. Cerebrovasc Dis 2000;10:170–82.
Servan J, Verstichel P, Catala M, Rancurel G. Syndromes amnésiques et fabulations au cours d’infarctus du territoire de l’artère cérébrale postérieure. Rev Neurol (Paris) 1994;150:201–208.
Swartz RH, Sahlas DJ, Black SE, et al. Strategic involvement of cholinergic pathways and executive dysfunction: does location of white matter signal hyperintensity matter? J Stroke Cerebrovasc Dis 2003;12:29–36.
Mann DM, Yates PO, Marcyniuk B. The nucleus basalis of Meynert in multi-infarct (vascular) dementia. Acta Neuro-pathol (Berl) 1986;71:332–337.
Richardson JT. Cognitive performance following rupture and repair of intracranial aneurysms. Acta Neurol Scand 1991;83:110–122.
von Cramon DY, Markowitsch HJ. Human memory dysfunctions due to septal lesions. In: Numan R, ed. The behavioral neuroscience of the septal region. New York, NY: Springer, 2000, pp. 380–413.
Phillips S, Sangalang V, Sterns G. Basal forebrain infarction. A clinicopathologic correlation. Arch Neurol 1987;44:1134–1138.
Looi JCL, Sachdev PS. Differentiation of vascular dementia from AD on neuropsychological tests. Neurology 1999;53:670–678.
Castaigne P, Buge A, Cambier J, Escourolle R, Brunet P, Degos JD. Démence thalamique d’origine vasculaire par ramollissement bilatéral, limité au territoire du péduncule retromamillaire. A propos de deux observations anatomo-cliniques. Rev Neurol (Paris) 1966;114:89–107.
Castaigne P, Lhermitte F, Buge A, et al. Paramedian thalamic and midbrain infarcts: clinical and neuropathological study. Ann Neurol 1981;10:127–148.
Katz DI, Alexander MP, Mandell AM. Dementia following strokes in the mesencephalon and diencephalon. Arch Neurol 1987;44:1127–1133.
von Cramon DY, Hebel N, Schuri U. A contribution to the anatomical basis of thalamic amnesia. Brain 1985;108:993–1008.
Van der Werf Y, Witter MP, Uylings HB, Jolles J. Neuropsychology of infarctions in the thalamus: a review. Neuropsychologia 2000;38:613–627.
Ghika-Schimid F, Bogousslavsky J. The acute behavioral syndrome of anterior thalamic infarction: a prospective study of 12 cases. Ann Neurol 2000;48:220–227.
Tatemichi TK, Desmont DW, Prohovnik I, et al. Confusion and memory loss from capsular genu infarction: a thalamo-cortical disconnection syndrome? Neurology 1992;42:1966–1979.
Tatemichi TK, Desmont DW, Prohovnik I, et al. Strategic infarcts in vascular dementia. A clinical and imaging experience. Arzneimittel-Forschung/Drug Res 1995;45:371–385.
Madureira S, Guerreiro M, Ferro JM. A follow-up study of cognitive impairment due to inferior capsular genu infarction. J Neurol 1999;246:764–769.
Pantoni L, Basile AM, Romanelli M, et al. Abulia and cognitive impairment in two patients with capsular genu infarct. Acta Neurol Scand 2001;104:185–190.
Ghika J, Bogousslavsky J, Regli F. Infarcts in the territory of the deep perforators from the carotid system. Neurology 1989;39:507–512.
Chukwudelunzu FE, Meschia JF, Graff-Radford NR, Lucas JA. Extensive metabolic and neuropsychological abnormalities associated with discrete infarction of the genu of the internal capsule. J Neurol Neurosurg Psychiatry 2001;71:658–662.
Caplan LR, Schmahmann JD, Kase CS, et al. Caudate infarcts. Arch Neurol 1990;47:133–143.
Kumral E, Evyapan D, Balkir K. Acute caudate vascular lesions. Stroke 1999;30:100–108.
Tournier-Lasserve E, Joutel A, Melki J, et al. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy maps to chromosome 19ql2. Nat Genet 1993;3:256–259.
Joutel A, Vahedi K, Corpechor C, et al. Strong clustering and stereotyped nature of mutations in CADASIL patients. Lancet 1997;350:1511–1515.
Dichgans M, Herzog J, Gasser T. Notch3 mutation involving three cysteine residues in a family with typical CADASIL. Neurology 2001;57:1714–1717.
Erkinjuntti T, Inzitari D, Pantoni L, et al. Research criteria for subcortical vascular dementia in clinical trials. J Neural Transmission 2000;59(Suppl):23–30.
Fisher CM. Lacunes: small deep cerebral infarcts. Neurology 1965;15:774–784.
Román GC. Senile dementia of the Binswanger type: a vascular form of dementia in the elderly. JAMA 1987;258:1782–1788.
Román GC. The identity of lacunar dementia and Binswanger disease. Med Hypotheses 1985;16:389–391.
Ruchoux MM, Guerouaou D, Vandenhaute B, et al. Systemic vascular smooth muscle impairment in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Acta Neuropathol (Berl) 1995;89:500–512.
Joutel A, Favrole P, Labauge P, et al. Skin biopsy immunostaining with a Notch3 monoclonal antibody for CADASIL diagnosis. Lancet 2001;358:2049–2051.
Natte R, Maaat-Schieman ML, Haan J, et al. Dementia in hereditary cerebral hemorrhage with amyloidosis-Dutch type is associated with cerebral amyloid angiopathy but is independent of plaques and neurofibrillary tangles. Ann Neurol 2001;50:765–772.
Mead S, James-Galton M, Revesz T, et al. Familial British dementia with amyloid angiopathy: early clinical, neuropsychological and imaging findings. Brain 2000;123:975–991.
Ghiso J, Revesz T, Holton J, et al. Chromosome 13 dementia syndromes as models of neurodegeneration. Amyloid 2001;8:277–284.
Ghiso JA, Holton J, Miravalle L, et al. Systemic amyloid deposits in familial British dementia. J Biol Chem 2001;276:43,909–43,914.
Kramer JH, Reed BR, Mungas D, Weiner MW, Chui HC. Executive dysfunction in subcortical ischaemic vascular disease. J Neurol Neurosurg Psychiatry 2002;72:217–220.
Mungas D, Jagust WJ, Reed BR, et al. MRI predictors in subcortical ischemic vascular disease and Alzheimer’s disease. Neurology 2001;57:2229–2235.
Fein G, Di Sclafani V, Tanabe J, et al. Hippocampal and cortical atrophy predict dementia in subcortical ischemic vascular disease. Neurology 2000;55:1626–1635.
Vinters HV, Ellis WG, Zarow C, et al. Neuropathologic substrates of ischemic vascular dementia. J Neuropathol Exper Neurol 2000;59:931–945.
Hachinski VC, Iliff LD, Zilkha E, et al. Cerebral blood flow in dementia. Arch Neurol 1975;32:632–637.
Moroney JT, Bagiella E, Desmond DW, et al. Meta-analysis of the Hachinski ischemic score in pathologically verified dementias. Neurology 1997;49:1096–1105.
Petersen RC, Doody R, Kurz A, et al. Current concepts in mild cognitive impairment. Arch Neurol 2001;58:1985–1992.
Skoog I. Status of risk factors for vascular dementia. Neuroepidemiology 1998;17:2–9.
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Román, G.C. (2005). Clinical Forms of Vascular Dementia. In: Paul, R.H., Cohen, R., Ott, B.R., Salloway, S. (eds) Vascular Dementia. Current Clinical Neurology. Humana Press. https://doi.org/10.1385/1-59259-824-2:007
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