Functional Brain Imaging of Cerebrovascular Disease

  • Ronald Cohen
  • Lawrence Sweet
  • David F. Tate
  • Marc Fisher
Part of the Current Clinical Neurology book series (CCNEU)


One of the greatest challenges facing clinicians involved in the management of patients with cerebrovascular disease (CVD) is the detection and measurement of cerebral ischemia and associated metabolic changes that lead to infarctions in the brain (1, 2, 3, 4). Before the development of computed tomography (CT) methods, the diagnosis of stroke was largely dependent on the analysis of clinical signs and symptoms (5). Although clinical findings may suggest an evolving stroke in a small proportion of patients, in most cases, cognitive and behavioral impairments are observed in the aftermath of a stroke that has caused a brain lesion resulting from infarction (1, 2, 3, 4, 5, 6, 7, 8, 9). The use of standard CT and magnetic resonance imaging (MRI) as routine clinical procedures greatly facilitated the detection of brain abnormalities associated with stroke (10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23), although these structural brain imaging methods have had only limited value in routine clinical management. Standard CT and MRI methods are excellent for detecting cerebral infarctions (15,19,23), but physiologically abnormal tissue that is not completely necrotic often goes undetected (24, 25, 26). The development of ultrafast and serial structural imaging methods has improved the early diagnosis of stroke (18,19,25, 26, 27, 28), but these methods still have limitations (29,30).


White Matter Apparent Diffusion Coefficient Functional Magnetic Resonance Imaging Vascular Dementia Cerebral Blood Volume 
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Copyright information

© Humana Press Inc., Totowa, NJ 2005

Authors and Affiliations

  • Ronald Cohen
    • 1
  • Lawrence Sweet
    • 1
  • David F. Tate
    • 1
  • Marc Fisher
    • 2
  1. 1.Department of Psychiatry and Human BehaviorBrown Medical SchoolProvidence
  2. 2.Department of NeurologyUniversity of Massachusetts Medical SchoolWorcester

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