The Neuropathologic Substrates of Vascular-Ischemic Dementia

  • Kurt A. Jellinger
Part of the Current Clinical Neurology book series (CCNEU)


Although Alzheimer’s disease (AD) has become widely accepted as the most common cause of dementia in advanced age (1), the role of cerebrovascular disease (CVD) and ischemic brain lesions in cognitive decline remains controversial and confusing (2, 3, 4, 5). Until the 1950 and 1960s, dementia in elderly subjects was usually labeled “atherosclerotic dementia,” although in 1919, Mingazzini (6) stated that this was the result of cerebral infarctions, similar to the concept stressed by Fisher (7). Tomlinson et al. (8) described the relationship between the volume of infarcted tissue and cognitive impairment, suggesting that destruction of large volumes of cortex may be necessarily followed by dementia, whereas subtle cerebrovascular lesions (CVLs) may or may not contribute to dementia, probably depending on their location. Hachinsky et al. (9) criticized the term “arteriosclerotic dementia” as both inaccurate and misleading and coined the term “multi-infarct dementia” (MID). Because MID constitutes only a small subdivision of all dementias of vascular etiology, the terms “vascular dementia” (VaD) (4,10, 11, 12, 13), “cerebrovascular dementia” (14), “dementia associated with stroke” (15), or, more recently, “ischemic-vascular dementia” (16,17) “vascular-ischemic dementia” or “vascular cognitive impairment” (ViD) (18) were chosen.


Alzheimer Disease Dementia With Lewy Body Vascular Dementia Cerebral Amyloid Angiopathy Anterior Cerebral Artery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Humana Press Inc., Totowa, NJ 2005

Authors and Affiliations

  • Kurt A. Jellinger
    • 1
  1. 1.Institute of Clinical Neurobiology and University of ViennaViennaAustria

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