Abstract
The purpose of any clinical trial is to evaluate treatment(s) in an at-risk population. Clinical trial design principles are the same regardless of the setting. Three very readable books that cover fundamentals and specifics of clinical trial design are those by Friedman, Furberg, and DeMets (1); Meinert (2); and Pocock (3). Clinical trial design is much more than inclusion/exclusion criteria, sample size, randomization to treatment arm, and counting endpoints. Defining and monitoring data collection, monitoring and maintaining compliance, and monitoring and reporting potential adverse events are often the most demanding design aspects.
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© 2005 Humana Press Inc., Totowa, NJ
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Hallstrom, A. (2005). Design of Clinical Trials Relating to Medical Emergencies. In: Ornato, J.P., Peberdy, M.A. (eds) Cardiopulmonary Resuscitation. Contemporary Cardiology. Humana Press. https://doi.org/10.1385/1-59259-814-5:695
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DOI: https://doi.org/10.1385/1-59259-814-5:695
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