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Biological Weapons Defense pp 435–452Cite as

Genomics for Biodefense

Exploiting the Francisella tularensis Genome Sequence

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Part of the book series: Infectious Disease ((ID))

Abstract

Francisella tularensis is the aetiological agent of tularemia, a plague-like disease of rodents capable of being transmitted to man. Tularemia is a zoonosis, found in a wide range of animals such as rabbits, hares, rodents, and beavers (1). Transmission occurs usually through the bite of an insect, such as a tick, biting fly, or mosquito (2–5) but can also be through ingestion of infected foodstuffs (3) and drinking water (6), or through inhalation of the bacterium (7). In humans, the most common presentation is ulceroglandular tularemia, a disease typified by flu-like symptoms, normally with a low mortality rate (8). An ulcer forms at the site of infection, which can persist for several months. Other forms of tularemia, such as typhoidal, gastrointestinal, and pneumonic tularemia, are more serious diseases and may have mortality rates up to 60%, depending on the type of strain causing infection (7). F. tularensis subspecies tularensisis one of the most infectious pathogens known, with an infectious dose of less than 10 colony-forming units (CFU) in humans (9,10).

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Authors and Affiliations

  1. Department of Molecular Evolution, University of Uppsala, Sweden

    Siv G. E. Andersson PhD

  2. National Defence Research Establishment, Umeå, Sweden

    Mats Forsman PhD

  3. Defence Science and Technology Laboratory, CBS Porton Down, Salisbury, Wilts, UK

    Petra C. F. Oyston PhD & Richard W. Titball PhD

  4. Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK

    Richard W. Titball PhD

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  1. Department of Homeland Security, Science and Technology Directorate, National Biodefense Analysis and Countermeasures Center, Fort Detrick, MD

    Luther E. Lindler PhD  & George W. Korch PhD (Deputy Director) &  (Deputy Director)

  2. Department of Bacterial Diseases, Walter Reed Army Institute of Research, Silver Spring, MD

    Luther E. Lindler PhD

  3. Department of Cell Biology and Biochemistry, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD

    Frank J. Lebeda PhD

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Andersson, S.G.E., Forsman, M., Oyston, P.C.F., Titball, R.W. (2005). Genomics for Biodefense. In: Lindler, L.E., Lebeda, F.J., Korch, G.W. (eds) Biological Weapons Defense. Infectious Disease. Humana Press. https://doi.org/10.1385/1-59259-764-5:435

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  • DOI: https://doi.org/10.1385/1-59259-764-5:435

  • Publisher Name: Humana Press

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  • Online ISBN: 978-1-59259-764-2

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