Medical Protection Against Brucellosis

  • David L. Hoover
  • Richard H. Borschel
Part of the Infectious Disease book series (ID)

Abstract

Human brucellosis is a systemic, febrile illness caused by at least five different species of Brucella, a Gram-negative, aerobic, nonmotile, nonspore-forming coccobacillus. It has long been considered a prime biowarfare threat agent. As an intracellular parasite of mononuclear phagocytes, it successfully evades many host immune responses and resists easy eradication by antimicrobial agents. These characteristics both increase the need for effective strategies to protect against infection and create challenges to development of vaccines and other antimicrobial countermeasures against the organism.

Keywords

Attenuation Bacillus Streptomycin Meningitis Tetracycline 

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Copyright information

© Humana Press Inc., Totowa, NJ 2005

Authors and Affiliations

  • David L. Hoover
    • 1
  • Richard H. Borschel
    • 1
  1. 1.Department of Bacterial DiseasesWalter Reed Army Institute of ResearchSilver Spring

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