Abstract

Sudden infant death syndrome (SIDS) is a postmortem diagnosis that identifies an infant, usually less than 1 yr old, who dies a sudden and unexpected natural death during sleep and the cause of death is not apparent after autopsy. The differential diagnosis of SIDS from other causes of infant death is often difficult. Even after an adequate autopsy, approx 85% of cases of sudden death in infants (including SIDS) remain unexplained; the other 15% comprise a variety of explained disorders.

Keywords

Pneumonia Cortisol Morphine Diarrhea Dehydration 

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References

  1. Arens R, Gozal D, Jain K, et al. Prevalence of medium-chain acyl-coenzyme A dehydrogenase deficiency in the sudden infant death syndrome. J Pediatr 1993;122:715–718.PubMedCrossRefGoogle Scholar
  2. Barness EG, Barness LA. Sudden infant death. Florida Pediatr 2002;XXV(4):25–29.Google Scholar
  3. Bays J, Chewning M, Keltner L, et al. Changes in hymenal anatomy during examination of prepubertal girls for possible sexual abuse. Adolesc Pediatr Gynecol 1990;3:42–46.Google Scholar
  4. Beal S. Sudden infant death syndrome related to sleeping position and bedding. Med J Aust 1991;155:507–508.PubMedGoogle Scholar
  5. Beal BM, Byard RW. Accidental death or sudden infant death syndrome? J Paediatr Child Health 1995;31:269–271.PubMedCrossRefGoogle Scholar
  6. Beckwith JB. The sudden infant death syndrome. Curr Probl Ped 1973;3:1–37.Google Scholar
  7. Beckwith JB. Defining the sudden infant death syndrome. Arch Pediatr Adolesc Med 2003;157:286–290.PubMedGoogle Scholar
  8. Bennett MJ. The laboratory diagnosis of inborn errors of mitochondrial fatty acid oxidation. Ann Clin Biochem 1990;27:519–531.PubMedGoogle Scholar
  9. Bennett MJ, Allison F, Pollitt RJ, et al. Fatty acid oxidation defects as causes of unexpected death in infancy. In: Tanaka K, Coates PM, eds. Fatty Acid Oxidation; Clinical, Biochemical and Molecular Aspects, New York: Alan R. Liss, 1990, pp. 349–364.Google Scholar
  10. Bennett MJ, Hale DE, Coates PM, et al. Postmortem recognition of fatty acid oxidation disorders. Pediatr Pathol 1991;11:365–370.PubMedCrossRefGoogle Scholar
  11. Berry PJ. Pathological findings in SIDS. J Clin Pathol 1992;45(Suppl):11–16.PubMedGoogle Scholar
  12. Bohm N. Pediatric Autopsy Pathology. St. Louis: Mosby, 1988.Google Scholar
  13. Boles RG, Martin SK, Blitzer MG, et al. Biochemical diagnosis of fatty acid oxidation disorders by metabolite analysis of postmortem liver. Hum Pathol 1994;25:735–741.PubMedCrossRefGoogle Scholar
  14. Burchell A, Lyall H, Busuttil A, et al. Glucose metabolism and hypoglycaemia in SIDS. J Clin Pathol 1992; 45(Suppl):39–45.PubMedGoogle Scholar
  15. Byard RW, Moore L, Bourne AJ. Sudden and unexpected death. Pediatr Pathol 1990;10:837–841.PubMedCrossRefGoogle Scholar
  16. Chadwick DL, Chin S, Salerno C, et al. Deaths from falls in children: How far is fatal? J Trauma 1991; 31:1353–1355.PubMedGoogle Scholar
  17. Coates PM. Historical perspective of medium-chain acyl-CoA dehydrogenase deficiency: A decade of discovery. Prog Clin Biol Res 1992;375:409–423.PubMedGoogle Scholar
  18. Cravey RH, Baselt RC. Introduction to Forensic Toxicology. Davis, CA: Biomedical Publications, 1981.Google Scholar
  19. Culbertson JL, Krous HF, Bendell D. Sudden Infant Death Syndrome: Medical Aspects and Psychological Management. Baltimore: Johns Hopkins University Press, 1988.Google Scholar
  20. Czegledy-Nagy EN, Cutz E, Becker LE. Sudden death in infants under one year of age. Pediatr Pathol 1993; 13:671–684.PubMedCrossRefGoogle Scholar
  21. Dancea A, Cote A, Roblicek C, Bernard C, Oligny LL. Cardiac pathology in sudden unexpected infant death. J Pediatr 2002;141(3):336–342.PubMedCrossRefGoogle Scholar
  22. Devine WA, Debich D, Anderson RH. Dissection of congenitally malformed hearts, with comments on the value of sequential segmental analysis. Pediatr Pathol 1991;11:235–259.PubMedCrossRefGoogle Scholar
  23. Dominguez FE, Tate LG, Robinson MJ. Familial fibromuscular dysplasia presenting as sudden death. Am J Cardiovasc Pathol 1988;2:269–272.PubMedGoogle Scholar
  24. Duhaime AC, Gennarelli TA, Thibault LE, et al. The shaken baby syndrome. A clinical, pathological and biomechanical study. J Neurosurg 1987;66:409–415.PubMedGoogle Scholar
  25. Dwyer T, Ponsonby ALB, Newmann NM, et al. Prospective cohort study of prone sleeping position and sudden infant death syndrome. Lancet 1991;337:1244–1247.PubMedCrossRefGoogle Scholar
  26. Emery JL, Howat A, Variend S, et al. Investigation of inborn errors of metabolism in unexpected infant deaths. Lancet 1988;2:29–31.PubMedCrossRefGoogle Scholar
  27. Feigin RD, Cherry JD. Textbook of Pediatric Infectious Diseases, Philadelphia: WB Saunders, 1987.Google Scholar
  28. Friendly DS. Ocular aspects of physical child abuse. In: Hurley RD, ed. Pediatric Ophthalmology, 2nd ed., Vol. II. Philadelphia: WB Saunders, 1983, pp. 1218–1222.Google Scholar
  29. Gelb AB, Van Meter SH, Billingham ME, et al. Infantile histiocytoid cardiomyopathy—myocardial or conduction system hamartoma: What is the cell type involved? Hum Pathol 1993;24:1226–1231.PubMedCrossRefGoogle Scholar
  30. Gilbert R. The changing epidemiology of SIDS. Arch Dis Child 1994;70:445–449.PubMedGoogle Scholar
  31. Gilbert-Barness E, Barness LA. Sudden infant death: A reappraisal. Contemp Pediatr 1995;12:88–91.PubMedGoogle Scholar
  32. Gilbert-Barness E, Barness LA. Nonmalformative cardiovascular pathology in infants and children. Ped Dev Path 1999;2:499–530.CrossRefGoogle Scholar
  33. Gilbert-Barness E, Barness LA. Sudden infant death. In: Finberg L, Kleinman RE, eds. Saunders Manual of Pediatric Practice, 2nd ed., Philadelphia: WB Saunders, 2002, pp. 100–102.Google Scholar
  34. Gilbert-Barness E, Hegstrand L, Chandra S, et al. Hazards of mattresses, beds and bedding in sudden death of infants. Am J Forensic Med Pathol 1991;12:27–32.PubMedCrossRefGoogle Scholar
  35. Gilliland MGF, Luckenbach MW. Are retinal hemorrhages found after resuscitation attempts? Am J Forensic Med Pathol 1993;14:187–192.PubMedGoogle Scholar
  36. Giulian GG, Gilbert EF, Moss R. Elevated fetal hemoglobin levels in sudden infant death. N Engl J Med 1987;316:1122–1126.PubMedGoogle Scholar
  37. Gregersen M, Rajs J, Laursen H, et al. Pathologic criteria for the Nordic study of SIDS. In: Rognum TO, ed. Sudden Infant Death Syndrome. New Trends in the Nineties. Oslo: Scandinavian University Press, 1995, pp. 50–58.Google Scholar
  38. Guntheroth WG. Crib Death. The Sudden Infant Death Syndrome, 2nd revised ed., Mount Kisco, NY: Futura, 1989.Google Scholar
  39. Guo S, Moore WM. Weight and recumbent length from 1 to 12 months of age: Reference data for 1 month increments. Am J Clin Nutr 1989;49:599–607.PubMedGoogle Scholar
  40. Haddad LM, Winchester JF. Poisoning and Drug Overdose, 2nd ed., Philadelphia: WB Saunders, 1990.Google Scholar
  41. Helfer RE, Slovis TL, Black M. Injuries resulting when small children fall out of bed. Pediatrics 1977; 60:533–535.PubMedGoogle Scholar
  42. Hunt CE, Brouillette RT. Sudden infant death syndrome: 1987 perspective. J Pediatr 1987;110:669–678.PubMedCrossRefGoogle Scholar
  43. Isaksen CV, Helweg-Larsen K. The impact of attempted resuscitation in SIS: Port-mortem findings. In: Rognum TO, ed. Sudden Infant Death Syndrome. New Trends in the Nineties. Oslo: Scandinavian University Press, 1995.Google Scholar
  44. Johnson DL, Braun D, Friendly D. Accidental head trauma and retinal hemorrhage. Neurosurgery 1993;33:231–235.PubMedCrossRefGoogle Scholar
  45. Jones AM, Weston JT. The examination of the sudden infant death syndrome infant: investigative and autopsy protocols. Forensic Sci 1976;1:833–841.Google Scholar
  46. Kanter RK. Retinal hemorrhage after cardiopulmonary resuscitation or child abuse. J Pediatr 1986.Google Scholar
  47. Kemp JS, Thach BT. Sudden death in infants sleeping on polystyrene-filled cushions. N Engl J Med 1991; 324:1858–1863.PubMedGoogle Scholar
  48. Kinney HC, Filiano JJ, Sleeper LA, et al. Decreased muscarinic receptor binding in the arcuate nucleus in sudden infant death syndrome. Science 1995;269:1446–1450.PubMedCrossRefGoogle Scholar
  49. Kirschner R, Christoffel KK, Kerans ML, et al. Child Abuse/Neglect Autopsy Protocol, 1985. Convened by the Illinois Department of Children and Family Services and the Cook County Medical Examiner.Google Scholar
  50. Kleinman PK, Blackbourne BD, Marx SC, et al. Radiologic contributions to the investigation and prosecution of cases of fatal infant abuse. N Engl J Med 1989;320:507–511.PubMedGoogle Scholar
  51. Kramer K, Goldstein B. Retinal hemorrhages following cardiopulmonary resuscitation. Clin Pediatr 1993; 32:366–368.CrossRefGoogle Scholar
  52. Krous HF. Pathological considerations of sudden infant death syndrome. Pediatrics 1988;15:231–239.Google Scholar
  53. Krous HF. The international standardized autopsy protocol for sudden infant death. In: Rognum TO, ed. Sudden Infant Death Syndrome. New Trends in the Nineties. Oslo: Scandinavian University Press, 1995:81–95.Google Scholar
  54. Krous HF, Jordan J. A necropsy study of the distribution of petechiae in non-sudden infant death syndrome. Arch Pathol Lab Med 1984;108:75–76.PubMedGoogle Scholar
  55. Leestma JE. Forensic Neuropathology. New York: Raven Press, 1998.Google Scholar
  56. Levin AV, Sheridan MS. Munchausen syndrome by proxy. In: Issues in Diagnosis and Treatment. New York: Lexington Books, 1995.Google Scholar
  57. Maron BJ, Edwards JE, Henry WL, et al. Asymmetric septal hypertrophy (ASH) in infancy. Circulation 1974; 50:809–820.PubMedGoogle Scholar
  58. Mason JK, ed. Pediatric Forensic Medicine and Pathology. London: Chapman and Hall, 1989.Google Scholar
  59. McKenna JJ, Thoman EB, Anders TF. Infant-parent co-sleeping in an evolutionary perspective: implications for understanding infant sleep development and the sudden infant death syndrome (a review). Sleep 1993;16:263.PubMedGoogle Scholar
  60. Mirchandani HG, et al. Passive inhalation of free-base cocaine (crack) smoked by infants, Arch Pathol Lab Med 1991;115:494–498.PubMedGoogle Scholar
  61. Nimityongskul P, Anderson L. The likelihood of injuries when children fall out of bed. J Pediatr Orthop 1987;7:184–186.PubMedGoogle Scholar
  62. Norman MG, Smialek JE, Newman DE, et al. The postmortem examination on the abused child, pathological, radiographic and legal aspects. Perspect Pediatr Pathol 1984;8:313–343.PubMedGoogle Scholar
  63. Rao VJ, Wetli CV. The forensic significance of conjunctival petechiae. Am J Forensic Med Pathol 1988;9:32–34.PubMedCrossRefGoogle Scholar
  64. Reece RM, ed. Child Abuse: A Medical Reference, 2nd ed. New York: Churchill Livingstone, 1992.Google Scholar
  65. Roe GR, Millington DS, Maltby DA, et al. Postmortem recognition of inherited disorders from specific acylcarnitines in tissues in cases of sudden infant death. Lancet 1987;2:512.CrossRefGoogle Scholar
  66. Rognum TO, ed. Suddent Infant Death Syndrome. New Trends in the Nineties. Oslo: Scandinavian University Press, 1995; pp. 70–73.Google Scholar
  67. Rognum TO. SIDS or not SIDS? Classification problems of sudden infant death syndrome. Acta Paediatr 1996; 85:401–403.PubMedCrossRefGoogle Scholar
  68. Schultz DB, Giordano DA, Schultz DM. Weights of organs of fetuses and infants. Arch Pathol 1962;74:244.Google Scholar
  69. Schulz DM, Giordano DA. Hearts of infants and children. Arch Pathol 1962;74:464–471.PubMedGoogle Scholar
  70. Schwartz PJ, Stramba-Badiale M, Seganti A, et al. Prolongation of the QT interval and the sudden infant death syndrome. N Engl J Med 1998;38:1709–1714.CrossRefGoogle Scholar
  71. Smialek JE, Lambros Z. Investigation of sudden infant death. Pediatrics 1988;15:191–197.Google Scholar
  72. Smialek MD, Smialek PZ, Spitz WN. Accidental bed deaths in infants due to unsafe sleeping conditions. Clin Pediatr 1977;16:1031–1036.CrossRefGoogle Scholar
  73. Sturner WQ, Spruill FG, et al. Accidental asphyxial deaths involving infants and young children. J Forensic Sci 1976;21:483–487.PubMedGoogle Scholar
  74. Takashima S, Armstrong D, Becker L, et al. Cerebral hypoperfusion in the sudden infant death syndrome? Brainstem gliosis and vasculature. Ann Neurol 1978;4:257–262.PubMedCrossRefGoogle Scholar
  75. Treem WR, Witzleben CA, Piccoli DA, et al. Medium-chain and long-chain acyl-CoA dehydrogenase deficiency: clinical, pathologic and ultrastructural differentiation from Reye’s syndrome. Hepatology 1986;6:1270–1278.PubMedCrossRefGoogle Scholar
  76. Valdes-Dapena M, Huff D. Perinatal Autopsy Manual. Armed Forces Institute of Pathology Fascicle, Washington, DC.Google Scholar
  77. Valdes-Dapena M, Gilbert-Barness E, Naeye RL. Sudden death in infants. In: Gilbert-Barness E, ed. Potter’s Pathology of Infant and Fetus. Philadelphia: Mosby Year Book.Google Scholar
  78. Werthammer J, Brown ER, Neff RK, et al. Sudden infant death syndrome in infants with bronchopulmonary dysplasia. Pediatrics 1982;69:301–303.PubMedGoogle Scholar
  79. Willinger M, James LS, Catz C. Defining the sudden infant death syndrome (SIDS): Deliberations of an expert panel convened by the National Institutes of Child Health and Human Development. Pediatr Pathol 1991;11:667–684.CrossRefGoogle Scholar
  80. Willinger M, Hoffman HJ, Hartford RB. Infant sleep position and risk for sudden infant death syndrome: Report of meeting held January 13 and 14, 1984. National Institutes of Health, Bethesda, MD. Pediatrics 1994;93:814–819.Google Scholar
  81. Wilson EF. Estimation of the age of cutaneous contusions in child abuse. Pediatrics 1977;60:750.PubMedGoogle Scholar
  82. Wissow LS. Child abuse and neglect. N Engl J Med 1996;332:1425–1431.CrossRefGoogle Scholar
  83. Zupancic JA, Friedman JK, Alexander M, et al. Cost effectiveness and implication of newborn screening of prolongation of QT interval for prevention of sudden infant death syndrome. J Pediatr 2000;136:481–489.PubMedCrossRefGoogle Scholar

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