Abstract
The personalisation, prediction and optimisation of treatment have always been at the heart of European efforts to realise the full potential of Information antd Communication Technologies (ICT) for health. This chapter reviews the success story of the European Virtual Physiological Human (VPH) initiative, which is rooted in longstanding efforts of European Union (EU) initiatives in ICT for Health. This contribution outlines the origins of the VPH initiative in a European Union context and presents the work on the Digital Patient as an example of th VPH contribution to individualised and patient-centred medicine. A roadmap towards Digital Patient is outlined, presenting a vision and a trajectory for the way in which advances in physiological modelling could greatly enhance the quality and accuracy of healthcare and lifestyle interventions, thereby improving the health of patients and the effectiveness of clinicians and clinical teams.
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References
Baker, M. (2013), “Big Biology — the ornes Puzzle”, Nature 494(7438): 416–419.
Ballester, M.A.G., del Palomar, A.P., Villalobos, J. L.L., Rodriguez, L.L., Trabelsi, O., Perez, F., Canamaque, A.G., Cortés, E.B., Panadero, F.R., Castellano, M.D. and Jover, J.H. (2009), “Surgical planning and patient-specific biomechanical simulation for tracheal endoprostheses interventions”, in Yang, G. Z., Hawkes, D.J., Rueckert, D., Noble, J.A. and Taylor, C.J. (eds) Medical Image Computing and Computer-Assisted Intervention, MICCAI 2009, London, UK: Springer, pp. 275–282.
Brenner, S., Noble, D., Sejnowski, T., Fields, R.D., Laughlin, S., Berridge, M., Segel, L., Prank, K. and Dolmetsch, R.E. (2001), “Understanding complex systems: top-down, bottom-up or middle-out?”, in Bock, G.R. and Goode, J.A. (eds) Complexity in Biological Information Processing, John Wiley & Sons, pp. 155–159.
Deligianni, F., Chung, A. and Yang, G.Z. (2004), “Patient-specific bronchoscope simulation with pq-space-based 2D/3D registration”, Computer Aided Surgery 9(5): 215–226.
Díaz, V., Viceconti, M., Kalra, D. and Stroetmann, V. (2013), DISCIPULUS — Digital Patient Roadmap, London.
European Commission (2004), Applications relating to health, fifth research and development framework programme 1998–2002, Information Society Directorate-General, Unit Bl — Applications relating to Health, Luxemburg.
European Commission (2011), Horizon 2020-The Framework Programme for Research and Innovation, Brussels.
Fenner, J.W., Brook, B., Clapworthy G., Coveney P.V., Feipel, V., Gregersen, H., Hose, D.R., Kohl, P., Lawford, P., McCormack, K.M., Pinney D., Thomas, S.R., Van Sint Jan, S., Waters, S. and Viceconti, M. (2008), “The EuroPhysiome, STEP and a roadmap for the virtual physiological human”, Philosophical Transactions of the Royal Society of London. Series A: Mathematical Physical and Engineering Sciences 366(1878): 2979–2799.
Hunter, P., Coveney, P., de Bono, B., Díaz, V., Fenner, J., Frangi, A.F., Harris, P., Hose, R., Kohl, P., Lawford, P., McCormack, K., Mendes, M., Omholt, S., Quarteroni, A., Skår, J., Tegner, J., Randall, T., Tollis, I., Tsamardinos, I., van Beek, J.H. and Viceconti, M. (2010), “A vision and strategy for the virtual physiological human in 2010 and beyond”, Philosophical Transactions of the Royal Society of London. Series A: Mathematical Physical and Engineering Sciences 368(1920): 2595–2614.
Interagency Modeling and Analysis Group (2009), The Impact of Modeling on Biomedical Research, http://www.vph-institute.org/upload/imag-futures-report_519244d3a0aa0.pdf.
Kohl, P. and Noble, D. (2009), “Systems biology and the virtual physiological human”, Molecular Systems Biology, 5(292).
Martin-Sanchez, F., Iakovidis, I., Nèrager, S., Maojo, V., de Groen, P. and Van der Lei, J. (2004), “Synergy between medical informatics and bioinformatics: facilitating genomic medicine for future health care”, Journal of Biomedical Informatics 37(1): 30–42.
Noble, D. (2002), “Modeling the heart from genes to cells to the whole organ”, Science, 295(5560): 1678–1682.
Regierer, B., Zazzu, V., Sudbrak, R., K’hn, A. and Lehrach, H. (2013), “Future of medicine: models in predictive diagnostics and personalized medicine”, in Seitz, H. and Schumacher, S. (eds) Molecular Diagnostics Berlin Heidelberg: Springer-Verlag, pp. 15–33.
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© 2014 Vanessa Díaz-Zuccarini, Rainer Thiel and Veli Stroetmann
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Díaz-Zuccarini, V., Thiel, R., Stroetmann, V. (2014). The European Virtual Physiological Human Initiative. In: Rosenmöller, M., Whitehouse, D., Wilson, P. (eds) Managing eHealth. The Palgrave Macmillan IESE Business Collection. Palgrave Macmillan, London. https://doi.org/10.1057/9781137379443_19
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DOI: https://doi.org/10.1057/9781137379443_19
Publisher Name: Palgrave Macmillan, London
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