Skip to main content

From Measuring Environmental Toxins to Drugs as Contaminants

  • Chapter
Good Pharma

Abstract

On Saturday, July 10, 1976, at 12:37 p.m., a large explosion occurred at a chemical factory in Seveso, 15 kilometers from Milan, releasing a whitish cloud over several small towns downwind to the south.1 How toxic was the fallout? No one knew. Within the first days, however, many birds and domestic animals kept by residents in their small plots and homes began to die, and some children had to be treated in hospital for skin rashes or blisters from chemical burns.2 The company, ICMESA, a subsidiary of the Swiss company Givaudan, which was owned by Hoffman-La Roche, immediately started to look into the accident. However, they kept workers on the job, and they did not communicate much with public officials or residents in the area about the explosion or subsequent risks. As Luciano Manara and Silvio Garattini wrote, “No mention of the TCDD [2,3,7,8-Tetrachlorodibenzo-p-dioxin] risk was made to the local authorities before the disaster and even after it. Roche took almost two weeks to admit that TCDD had escaped from the plant.”3

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 16.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 54.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Notes

  1. Hay A. The Chemical Scythe: Lessons of 2, 4, 5-T, and Dioxin. New York: Plenum Press; 1982: Ch 9.

    Book  Google Scholar 

  2. Fanelli R, Chiabrando C, Bonaccorsi A. TCDD contamination in the Seveso incident. Drug Metabolism Reviews. 1982; 13 (3): 407–422.

    Article  Google Scholar 

  3. Manara L, Garattini S. Seveso: premature optimism. Nature. 1978; 276 (7): 556.

    Article  Google Scholar 

  4. Morgan SG, Bassett KL, Wright JM, et al. “Breakthrough” drugs and growth in expenditure on prescription drugs in Canada. BMJ. 2005; 331 (7520): 815–816.

    Article  Google Scholar 

  5. Light D, Lexchin J, Darrow J. Institutional corruption of pharmaceuticals and the myth of safe and effective drugs. Journal of Law, Medicine & Ethics. 2013; 41 (3): 590–600.

    Article  Google Scholar 

  6. MistraPharma. Collaborating to Reduce the Environmental Risks of Pharmaceuticals. Stockholm: Elanders Sverige; 2011; A leading policy group that brings together industry and government leaders to address medicines as environmental hazards is the Swedish organization, MistraPharma. They have written a series of informative short monographs: A Healthy Future—Pharmaceuticals in a Sustainable Society (2009), Towards Sustainable Pharmaceuticals in a Health Society (2010), Collaborating to Reduce the Environmental Risks of Pharmaceuticals (2011), and Pharmaceuticals in a Health Environment (2012).

    Google Scholar 

  7. Jefferson T, Doshi P, Thompson M, Heneghan C. Ensuring safe and effective drugs: who can do what it takes? BMJ. 2011; 342: c7258

    Google Scholar 

  8. Doshi P, Jones M, Jefferson T. Rethinking credible evidence synthesis. BMJ. 2012; 344: d7898

    Google Scholar 

  9. Sismondo S, Doucet M. Publication ethics and the ghost management of medical publication. Bioethics. 2010; 24 (6): 273–283

    Article  Google Scholar 

  10. Rodwin M. Conflicts of interest, institutional corruption, and Pharma: an agenda for reform. Journal of Law, Medicine & Ethics. 2012; 40 (Fall): 511–522.

    Article  Google Scholar 

  11. Bonaccorsi A, Fanelli R, Tognoni G. In the wake of Seveso. Ambro. 1978; 7: 237.

    Google Scholar 

  12. European Commission. Directive of the European Parliament and of the Council on control of major-accident hazards involving dangerous substances. Brussels: European Commission; 2010 (21.12)

    Google Scholar 

  13. Schecter A. Dioxins and Health: Including Other Persistent Organic Pollutants and Endocrine Disruptions, 3rd Edition. Hoboken, NJ: John Wiley & Sons; 2012.

    Book  Google Scholar 

  14. Markowitz G, Rosner D. Deceit and Denial: The Deadly Politics of Industrial Pollution. Berkeley: University of California Press; 2002.

    Google Scholar 

  15. Fanelli R. Interview. Milano: Mario Negri Institute; 2012 (May 8).

    Google Scholar 

  16. Mocarelli P, Gerthoux P, Brambilla P, Marocchi A, et al. Dioxin health effects on humans twenty years after Seveso: a summary. In: Ballarin-Denti A, Berazzi P, Facchetti S, Fanelli R, Mocarelli P, eds. Chemistry, Man and Environment: The Seveso Accident 20 Years On. Amsterdam: Elsevier; 1999: 41–51.

    Google Scholar 

  17. Morcarelli P, Brambill P, Patterson DJ, Needham L. Change in sex ratio with exposure to dioxin. The Lancet. 1996; 348 (9024): 409.

    Article  Google Scholar 

  18. Axelson O. The epidemiologic evidence of health effects of TCDD in human beings. In: Mocarelli P, Gerthoux P, Brambilla P, Marocchi A, et al., eds. Chemistry, Man and Environment: The Seveso Accident 20 Years On. Amsterdam: Elsevier; 1999: 29–38.

    Google Scholar 

  19. Delaney J. First X, Then Y, Now Z: An Introduction to Landmark Thematic Maps. Princeton, NJ: Princeton University Press for Firestone Library; 2012: 119–121; You can see his detailed map at http://libweb5.princeton.edu/visual_materials/maps/websites/thematic-maps/quantitative/medicine/medicine.html#Lancisi. Lancisi also analyzed fetid air in Rome and designed measures to reduce it. He is also regarded as the founder of cardiovascular pathology and described in detail angina pectoris half a century before William Heberden published his account of it. At the request of Clement XI, he analyzed an epidemic of sudden deaths in 1705, based on autopsies of the victims, and published a monograph on their causes.

    Google Scholar 

  20. Bonati M, Tognoni G. Has clinical pharmacology lost its way? The Lancet. 1984; 323 (8376): 556–558.

    Article  Google Scholar 

  21. Mariani G, Benfenati E, Fanelli R. Concentrations of PCDD and PCDF in different points on a modern refuse incinerator. Chemosphere. 1990; 21: 507–517.

    Article  Google Scholar 

  22. Bittman M. Opinionator: Breeding bacteria on factory farms. The New York Times. 2013 (July 9).

    Google Scholar 

  23. Kessler D. Antiobiotics and the meat we eat. The New York Times. 2013 (Mar 27).

    Google Scholar 

  24. Zuccato E, Calamari D, Natangelo M, Fanelli R. Presence of therapeutic drugs in the environment. The Lancet. 2000; 355 (9217): 1789–1790.

    Article  Google Scholar 

  25. WHO. Pharmaceuticals in Drinking-water. Geneva: The World Health Organization; 2011.

    Google Scholar 

  26. MistraPharma, Collaboration to reduce; Shah S. As Pharmaceutical Use Soars, Drugs Taint Water and Wildlife. New Haven, CT: Yale University; 2010.

    Google Scholar 

  27. Bienkowski B. Fish on Prozac: anxious, anti-social, aggressive. Environmental News. 2013 (June 12).

    Google Scholar 

  28. Lexchin J. New drugs and safety: what happened to new active substances approved in Canada between 1995 and 2010? Archives of Internal Medicine. 2012; 172 (21): 1680–1681.

    Article  Google Scholar 

  29. Kaiser Family Foundation. Prescription Drug Trends. Palo Alto, CA: Kaiser Family Foundation; 2010.

    Google Scholar 

  30. Zuccato E, Castiglioni S, Fanelli R, et al. Pharmaceuticals in the environment in Italy: causes, occurence, effects, and control. Environmental Science & Pollution Research. 2006; 13 (1): 15–21.

    Article  Google Scholar 

  31. Calamari D, Zuccato E, Castiglioni S, Fanelli R. Strategic survey of therapeutic drugs in the rivers Po and Lambro in northern Italy. Environmental Science & Technology. 2003; 37 (1241–48).

    Article  Google Scholar 

  32. Zuccato E, Chaibrando C, Castiglioni S, et al. Cocaine in surface water: a new evidence-based tool to monitor community drug abuse. Environmental Health. 2005; 4 (14): 1–7.

    Google Scholar 

  33. Khamsi R. Sewage study spots cocaine users. Nature News; 2005 (Aug 5).

    Google Scholar 

  34. Zuccato E, Castiglioni S, Bagnati R, Fanelli R. Estimating community drug abuse by wastewater analysis. Environmental Health Perspectives. 2008; 116 (8): 1027–1032.

    Article  Google Scholar 

  35. Castiglioni S, Zuccato E. Occurrence of illicit drugs in wastewater and surface water in Italy. In: Castiglioni S, Zuccato E, Fanelli R, eds. Illicit Drugs in the Environment. Hoboken, NJ: John Wiley & Sons; 2011: 137–151.

    Chapter  Google Scholar 

  36. Castiglioni S, Zuccato E, Fanelli R, eds. Illicit Drugs in the Environment. Hoboken, NJ: John Wiley & Sons; 2011.

    Google Scholar 

  37. Panawennage D, Castiglioni S, Zuccato E, Davoli E, Chiarelli M. Measurement of illicit drug consumption in small populations: prognosis for noninvasive drug testing of student populations. In: Castiglioni S, Zuccato E, Fanelli R, eds. Illicit Drugs in the Environment. Hoboken, NJ: John Wiley & Sons; 2011: 321–331.

    Chapter  Google Scholar 

Download references

Authors

Copyright information

© 2015 Donald W. Light and Antonio F. Maturo

About this chapter

Cite this chapter

Light, D.W., Maturo, A.F. (2015). From Measuring Environmental Toxins to Drugs as Contaminants. In: Good Pharma. Palgrave Macmillan, New York. https://doi.org/10.1057/9781137374332_6

Download citation

Publish with us

Policies and ethics