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Prenatal Exposure to Maternal Cigarette Smoking, Addiction, and the Offspring Brain

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Neuroimaging and Psychosocial Addiction Treatment

Abstract

Most psychiatric disorders start early in life: 50 percent by 14, and 75 percent by 24 years of age (Kessler et al., 2005). Combined with their lifelong course, psychiatric disorders are the leading cause of disability and, as such, the major cause of shortening our life span (Whiteford et al., 2013). Substance use is, unfortunately, a key part of this public health problem. First, substance use disorders (SUDs) alone contribute to about 5 percent of years lived with disability (YLD), as compared, for example, with 2.8 percent YLD due to cardiovascular disorders (Whiteford et al., 2013). Second, SUDs represent one of the most common comorbid conditions associated with other psychiatric disorders (Krishnan, 2005). It is clear that understanding factors that influence the person’s liability to develop and sustain an SUD is of high importance to our society for both social and economic reasons. In this context, two periods of human life stand out: 1) adolescence, as the time when drug experimentation emerges (Johnston LD, 2011); and 2) young adulthood, when the prevalence of substance use and misuse peaks (Johnston LD, 2009).

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References

  • Al Mamun, A., Lawlor, D. A., Alati, R., O’Callaghan, M. J., Williams, G. M., & Najman, J. M. (2006). ‘Does maternal smoking during pregnancy have a direct effect on future offspring obesity? Evidence from a prospective birth cohort study’, American Journal of Epidemiology, 164, 317–25.

    Article  PubMed  Google Scholar 

  • Anblagan, D., Jones, N. W., Costigan, C., Parker, A. J., Allcock, K., Aleong, R., … Gowland, R A. (2013). ‘Maternal smoking during pregnancy and fetal organ growth: A magnetic resonance imaging study’, Plos One, 8, E67223.

    Article  Google Scholar 

  • Baldo, B. A., Pratt, W. E., & Kelley A. E. (2010). ‘Control of fat intake by striatal opioids’, In J.-P. Montmayeur & J. Le Coutre (Eds.), Fat detection: Taste, texture, and post ingestive effects. (Boca Raton, FL: CRC Press).

    Google Scholar 

  • Barnes, M. J., Argyropoulos, G., & Bray, G. A. (2010). ‘Preference for a high fat diet, but not hyperphagia following activation of mu opioid receptors is blocked in AgRP knockout mice’, Brain Research, 1317, 100–7.

    Article  PubMed  PubMed Central  Google Scholar 

  • Boozer, C. N., Schoenbach, G., & Atkinson, R. L. (1995). ‘Dietary fat and adiposity: A dose-response relationship in adult male rats fed isocalorically’, American Journal of Physiology, 268, E546–50.

    Google Scholar 

  • Borsboom, D., Cramer, A. O., Schmittmann, V. D., Epskamp, S., & Waldorp, L. J. (2011). ‘The small world of psychopathology’, Plos One, 6, E27407.

    Article  Google Scholar 

  • Bray, G. A., & Popkin, B. M. (1998). ‘Dietary fat intake does affect obesity!’, The American Journal of Clinical Nutrition, 68, 1157–73.

    PubMed  Google Scholar 

  • Breton, C. V., Byun, H. M., Wenten, M., Pan, R, Yang, A., & Gilliland, F. D. (2009). ‘Prenatal tobacco smoke exposure affects global and gene-specific DNA methylation’, American Journal of Respiratory and Critical Care Medicine, 180, 462–7.

    Article  PubMed  PubMed Central  Google Scholar 

  • Bruin, J. E., Gerstein, H. C., & Holloway A. C. (2010). ‘Long-term consequences of fetal and neonatal nicotine exposure: A critical review’, Toxicological Sciences, 116, 364–74.

    Article  PubMed  PubMed Central  Google Scholar 

  • Cheetham, A., Allen, N. B., Whittle, S., Simmons, J. G., Yucel, M., & Lubman, D. I. (2012). ‘Orbitofrontal volumes in early adolescence predict initiation of cannabis use: A 4-year longitudinal and prospective study’, Biological Psychiatry, 71, 684–92.

    Article  PubMed  Google Scholar 

  • Chen, H., Parker, S. L., Matta, S. G., & Sharp, B. M. (2005). ‘Gestational nicotine exposure reduces nicotinic cholinergic receptor (nAChR) expression in dopaminergic brain regions of adolescent rats. European Journal of Neuroscience, 22, 380–8.

    Article  PubMed  Google Scholar 

  • Chen, P., & Jacobson, K. C. (2012). ‘Developmental trajectories of substance use from early adolescence to young adulthood: Gender and racial/ethnic differences’, Journal of Adolescent Health, 50, 154–63.

    Article  PubMed  PubMed Central  Google Scholar 

  • Comings, D. E., & Blum, K. (2000). ‘Reward deficiency syndrome: Genetic aspects of behavioral disorders’, Progress in Brain Research, 126, 325–41.

    Article  PubMed  Google Scholar 

  • Cornelius, M. D., & Day, N. L. (2009). ‘Developmental consequences of prenatal tobacco exposure’, Current Opinion In Neurology, 22, 121–5.

    Article  PubMed  PubMed Central  Google Scholar 

  • D’Onofrio, B. M., Rickert, M. E., Langstrom, N., Donahue, K. L., Coyne, C. A., Larsson, H., … Lichtenstein, P. (2012). ‘Familial confounding of the association between maternal smoking during pregnancy and offspring substance use and problems’, Archives of General Psychiatry, 69, 1140–50.

    Article  PubMed  PubMed Central  Google Scholar 

  • De Braekeleer, M. (1991). ‘Hereditary disorders in Saguenay-Lac-St-Jean (Quebec, Canada)’, Human Heredity, 41, 141–6.

    Article  PubMed  Google Scholar 

  • De Braekeleer, M., Mari, C., Verlingue, C., Allard, C., Leblanc, J. P., Simard, F., … Ferec, C. (1998). ‘Complete identification of cystic fibrosis transmembrane conductance regulator mutations in the CF population of Saguenay Lac-Saint-Jean (Quebec, Canada)’, Clinical Genetics, 53, 44–6.

    Article  PubMed  Google Scholar 

  • Delpisheh, A., Brabin, L., & Brabin, B. J. (2006). ‘Pregnancy, smoking and birth outcomes’, Womens Health (London, England), 2, 389–403.

    Article  Google Scholar 

  • Dlugos, A. M., Hamidovic, A., Hodgkinson, C., Shen, P. EL, Goldman, D., Palmer, A. A., & De Wit, H. (2011). ‘OPRM1 gene variants modulate amphetamine-induced euphoria in humans’, Genes, Brain and Behavior, 10, 199–209.

    Article  Google Scholar 

  • Dwyer, J. B., McQuown, S. C., & Leslie, F. M. (2009). ‘The dynamic effects of nicotine on the developing brain’, Pharmacology & Therapeutics, 122, 125–39.

    Article  Google Scholar 

  • Franke, R. M., Park, M., Belluzzi, J. D., & Leslie, F. M. (2008). ‘Prenatal nicotine exposure changes natural and drug-induced reinforcement in adolescent male rats’, European Journal of Neuroscience, 27, 2952–61.

    Article  PubMed  Google Scholar 

  • Grompe, M., St-Louis, M., Deniers, S. I., al-Dhalimy M., Leclerc, B., & Tanguay R. M. (1994). ‘A single mutation of the fumarylacetoacetate hydrolase gene in French Canadians with hereditary tyrosinemia type I’, New England Journal of Medicine, 331, 353–7.

    Article  PubMed  Google Scholar 

  • Guerrero-Preston, R., Goldman, L. R., Brebi-Mieville, P., Ili-Gangas, C., Lebron, C., Witter, F. R., … Sidransky D. (2010). ‘Global DNA hypomethylation is associated with in utero exposure to cotinine and perfluorinated alkyl compounds’, Epigenetics, 5, 539–46.

    Article  PubMed  PubMed Central  Google Scholar 

  • Haghighi, A., Melka, M. G., Bernard, M., Abrahamowicz, M., Leonard, G. T, Richer, L., … Pausova, Z. (2014). ‘Opioid receptor mu 1 gene, fat intake and obesity in adolescence’, Molecular Psychiatry, 19, 63–8.

    Article  PubMed  Google Scholar 

  • Haghighi, A., Schwartz, D. H., Abrahamowicz, M., Leonard, G. T, Perron, M., Richer, L., … Pausova, Z. (2013). ‘Prenatal exposure to maternal cigarette smoking, amygdala volume, and fat intake in adolescence’, JAMA Psychiatry, 70, 98–105.

    Article  PubMed  Google Scholar 

  • Hatsukami, D. K., Lemmonds, C., Zhang, Y., Murphy, S. E., Le, C., Carmella, S. G., & Hecht, S. S. (2004). ‘Evaluation of carcinogen exposure in people who used “reduced exposure” tobacco products’, Journal of the National Cancer Institute, 96, 844–52.

    Article  PubMed  Google Scholar 

  • Herberg, L., Doppen, W., Major, E., & Gries, F. A. (1974). ‘Dietary-induced hypertrophic-hyperplastic obesity in mice’, The Journal of Lipid Research, 15, 580–5.

    PubMed  Google Scholar 

  • Hibell, B., Guttormsson, U., Ahlström, S., Balakireva, O., Bjarnason, T., Kokkevi, A., & Kraus, L. (2012). The 2011 ESPAD report. Substance use among students in 36 European countries. Retrieved from The European School Survey Project on Alcohol and Other Drugs website: http://www.espad.org/Uploads/ESPAD_reports/2011/The_2011_ESPAD_Report_FULL_2012_10_29.pdf

    Google Scholar 

  • Hill, J. O., & Peters, J. C. (1998). ‘Environmental contributions to the obesity epidemic’, Science, 280, 1371–4.

    Article  PubMed  Google Scholar 

  • Hu, C. W., Hsu, Y. W., Chen, J. L., Tarn, L. M., & Chao, M. R. (2014). ‘Direct analysis of tobacco-specific nitrosamine NNK and its metabolite NNAL in human urine by LC-MS/MS: Evidence of linkage to methylated DNA lesions’, Archives of Toxicology, 88, 291–9.

    Article  PubMed  Google Scholar 

  • Ino, T. (2010). ‘Maternal smoking during pregnancy and offspring obesity: Metaanalysis’, Pediatrics International, 52, 94–9.

    Article  PubMed  Google Scholar 

  • Jen, K. L. (1988). ‘Effects of diet composition on food intake and carcass composition in rats’, Physiology & Behavior, 42, 551–6.

    Article  Google Scholar 

  • Johnston, L. D., O’Malley P. M., Bachman, J. G., & Schulenberg, J. E. (2008). Monitoring the Future national survey results on drug use, 1975–2007: Volume II, College students and adults ages 19–45 (NIH Publication No. 08–6418B). (Bethesda, MD: National Institute on Drug Abuse).

    Google Scholar 

  • Johnston, L. D., O’Malley, P. M., Bachman, J. G., & Schulenberg, J. E. (2012). Monitoring the Future national results on adolescent drug use: Overview of key findings, 2011. (Ann Arbor, MI: Institute for Social Research, The University of Michigan).

    Google Scholar 

  • Joubert, B. R., Haberg, S. E., Nilsen, R. M., Wang, X., Vollset, S. E., Murphy, S. K., … London, S. J. (2012). ‘450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy’, Environmental Health Perspectives, 120, 1425–31.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kafouri, S., Leonard, G., Perron, M., Richer, L., Seguin, J. R., Veillette, S., … Paus, T. (2009). ‘Maternal cigarette smoking during pregnancy and cognitive performance in adolescence’, International Journal of Epidemiology, 38, 158–72.

    Article  PubMed  Google Scholar 

  • Kandel, D. B., Griesler, P. C., & Schaffran, C. (2009). ‘Educational attainment and smoking among women: Risk factors and consequences for offspring’, Drug and Alcohol Dependence, 104 Suppl 1, S24–33.

    Article  Google Scholar 

  • Kenny, P. J. (2011). ‘Reward mechanisms in obesity: New insights and future directions’, Neuron, 69, 664–79.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kessler, R. C., Berglund, P., Dernier, O., Jin, R., Merikangas, K. R., & Walters, E. E. (2005). ‘Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the national comorbidity survey replication’, Archives of General Psychiatry, 62, 593–602.

    Article  PubMed  Google Scholar 

  • Klesges, R. C., Klesges, L. M., Haddock, C. K., & Eck, L. H. (1992). ‘A longitudinal analysis of the impact of dietary intake and physical activity on weight change in adults’, The American Journal of Clinical Nutrition, 55, 818–22.

    PubMed  Google Scholar 

  • Krishnan, K. R. (2005). ‘Psychiatric and medical comorbidities of bipolar disorder’, Psychosomatic Medicine, 67, 1–8.

    Article  PubMed  Google Scholar 

  • Lackmann, G. M., Salzberger, U., Tollner, U., Chen, M., Carmella, S. G., & Hecht, S. S. (1999). ‘Metabolites of a tobacco-specific carcinogen in urine from newborns’, Journal of the National Cancer Institute, 91, 459–65.

    Article  PubMed  Google Scholar 

  • Lambers, D. S., & Clark, K. E. (1996). ‘The maternal and fetal physiologic effects of nicotine’, Seminars in Perinatology, 20, 115–26.

    Article  PubMed  Google Scholar 

  • Lawrence, J., Chen, M., Xiong, F., Xiao, D., Zhang, H., Buchholz, J. N., & Zhang, L. (2011). ‘Foetal nicotine exposure causes PKC(cham) gene repression by promoter methylation in rat hearts’, Cardiovascular Research, 89, 89–97.

    Article  PubMed  PubMed Central  Google Scholar 

  • Leary S. D., Smith, G. D., Rogers, I. S., Reilly J.J., Wells, J. C., & Ness, A. R. (2006). ‘Smoking during pregnancy and offspring fat and lean mass in childhood’, Obesity (Silver Spring), 14, 2284–93.

    Article  Google Scholar 

  • Lee, K. W. K., & Pausova, Z. (2013). ‘Cigarette smoking and DNA methylation’, Frontiers in Genetics, 4, 132.

    PubMed  PubMed Central  Google Scholar 

  • Lee, K. W. K., Abrahamowicz, M., Leonard, G. T., Richer, L., Perron, M., Veillette, S., … Pausova, Z. (2014). ‘Prenatal exposure to cigarette smoke interacts with OPRM1 to modulate dietary preference for fat’, Journal of Psychiatry and Neuroscience.

    Google Scholar 

  • Levin, B. E., Triscari, J., & Sullivan, A. C. (1986). Metabolic features of diet-induced obesity without hyperphagia in young rats’, American Journal of Physiology, 251, R433–40.

    Google Scholar 

  • Li-Byarlay H., Li, Y., Stroud, H., Feng, S., Newman, T. C., Kaneda, M., … Robinson, G. E. (2013). ‘RNA interference knockdown of DNA methyl-transferase 3 affects gene alternative splicing in the honey bee’, Proceedings of The National Academy of Sciences of The United States of America, 110, 12750–5.

    Article  PubMed  PubMed Central  Google Scholar 

  • Lin, R. K., Hsieh, Y. S., Lin, P., Hsu, H. S., Chen, C. Y, Tang, Y A., … Wang, Y C. (2010). ‘The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients’, Journal of Clinical Investigation, 120, 521–32.

    Article  PubMed  PubMed Central  Google Scholar 

  • Lotfipour, S., Ferguson, E., Leonard, G., Perron, M., Pike, B., Richer, L., … Paus, T. (2009). ‘Orbitofrontal cortex and drug use during adolescence: Role of prenatal exposure to maternal smoking and BDNF genotype’, Archives of General Psychiatry, 66, 1244–52.

    Article  PubMed  Google Scholar 

  • Maunakea, A. K., Nagarajan, R. P., Bilenky M., Ballinger, T. J., D’Souza, C., Fouse, S. D., … Costello, J. F. (2010). ‘Conserved role of intragenic DNA methylation in regulating alternative promoters’, Nature, 466, 253–7.

    Article  PubMed  PubMed Central  Google Scholar 

  • Noonan, M. P., Rolling, N., Walton, M. E., & Rushworth, M. F. (2012). ‘Re-evaluating the role of the orbitofrontal cortex in reward and reinforcement’, European Journal of Neuroscience, 35, 997–1010.

    Article  PubMed  Google Scholar 

  • Nyberg, L., Lovden, M., Riklund, K., Lindenberger, U., & Backman, L. (2012). ‘Memory aging and brain maintenance’, Trends In Cognitive Sciences, 16, 292–305.

    Article  PubMed  Google Scholar 

  • Oken, E., Huh, S. Y, Taveras, E. M., Rich-Edwards, J. W., & Gillman, M. W. (2005). ‘Associations of maternal prenatal smoking with child adiposity and blood pressure’, Obesity Research, 13, 2021–8.

    Article  PubMed  PubMed Central  Google Scholar 

  • Oken, E., Levitan, E. B., & Gillman, M. W. (2008). ‘Maternal smoking during pregnancy and child overweight: Systematic review and meta-analysis’, International Journal of Obesity, 32, 201–10.

    Article  PubMed  PubMed Central  Google Scholar 

  • Oscai, L. B., Brown, M. M., & Miller, W. C. (1984). ‘Effect of dietary fat on food intake, growth and body composition in rats’, Growth, 48, 415–24.

    PubMed  Google Scholar 

  • Oscai, L. B., Miller, W. C., & Arnall, D. A. (1987). ‘Effects of dietary sugar and of dietary fat on food intake and body fat content in rats’, Growth, 51, 64–73.

    PubMed  Google Scholar 

  • Park, H., & Poo, M. M. (2013). ‘Neurotrophin regulation of neural circuit development and function’, Nature Reviews Neuroscience, 14, 7–23.

    Article  PubMed  Google Scholar 

  • Paus, T., Bernard, M., Chakravarty, M. M., Davey Smith, G., Gillis, J., Lourdusamy A., … Pausova, Z. (2012). ‘KCTD8 gene and brain growth in adverse intrauterine environment: A genome-wide association study’, Cerebral Cortex, 22, 2634–42.

    Article  PubMed  PubMed Central  Google Scholar 

  • Paus, T., Nawazkhan, I., Leonard, G., Perron, M., Pike, G. B., Pitiot, A., … Pausova, Z. (2008). ‘Corpus callosum in adolescent offspring exposed prenatally to maternal cigarette smoking’, Neuroimage., 40, 435–41.

    Article  PubMed  Google Scholar 

  • Pausova, Z., Paus, T., Abrahamowicz, M., Almerigi, J., Arbour, N., Bernard, M., … Watkins, K. (2007). ‘Genes, maternal smoking, and the offspring brain and body during adolescence: Design of the Saguenay Youth Study’, Human Brain Mapping, 28, 502–18.

    Article  PubMed  Google Scholar 

  • Power, C., Atherton, K., & Thomas, C. (2010). ‘Maternal smoking in pregnancy, adult adiposity and other risk factors for cardiovascular disease’, Atherosclerosis, 211, 643–8.

    Article  PubMed  Google Scholar 

  • Power, C., & Jefferis, B. J. (2002). ‘Fetal environment and subsequent obesity: A study of maternal smoking’, International Journal of Epidemiology, 31, 413–19.

    Article  PubMed  Google Scholar 

  • Rehan, V. K., Liu, J., Naeem, E., Tian, J., Sakurai, R., Kwong, K., … Torday J. S. (2012). ‘Perinatal nicotine exposure induces asthma in second generation offspring’, BMC Medicine, 10, 129.

    Article  PubMed  PubMed Central  Google Scholar 

  • Russo, S. J., Mazei-Robison, M. S., Abies, J. L., & Nestler, E. J. (2009). ‘Neurotrophic factors and structural plasticity in addiction’, Neuropharmacology, 56 Suppl 1, 73–82.

    Article  PubMed  PubMed Central  Google Scholar 

  • Satta, R., Maloku, E., Zhubi, A., Pibiri, F., Hajos, M., Costa, E., & Guidotti, A. (2008). ‘Nicotine decreases DNA methyltransferase 1 expression and glutamic acid decarboxylase 67 promoter methylation in GABAergic interneurons’, Proceedings of The National Academy of Sciences of The United States of America, 105, 16356–61.

    Article  PubMed  PubMed Central  Google Scholar 

  • Schor, I. E., Fiszbein, A., Petrillo, E., & Kornblihtt, A. R. (2013). ‘Intragenic epigenetic changes modulate NCAM alternative splicing in neuronal differentiation’, The EMBO Journal, 32, 2264–74.

    Article  PubMed  PubMed Central  Google Scholar 

  • Schuller, H. M., Jorquera, R., Lu, X., Riechert, A., & Castonguay A. (1994). ‘Transplacental carcinogenicity of low doses of 4-(methylnitrosamino)-l-(3-pyridyl)-l-butanone administered subcutaneously or intratracheally to hamsters’, Journal of Cancer Research and Clinical Oncology, 120, 200–3.

    Article  PubMed  Google Scholar 

  • Schumann, G., Loth, E., Banaschewski, T., Barbot, A., Barker, G., Buchel, C., … Consortium, I. (2010). ‘The IMAGEN study: Reinforcement-related behaviour in normal brain function and psychopathology’, Molecular Psychiatry, 15, 1128–39.

    Article  PubMed  Google Scholar 

  • Shahrzad, S., Bertrand, K., Minhas, K., & Coomber, B. L. (2007). ‘Induction of DNA hypomethylation by tumor hypoxia’, Epigenetics, 2, 119–25.

    Article  PubMed  Google Scholar 

  • Shamblen, S. R., & Derzon, J. H. (2009). ‘A preliminary study of the population-adjusted effectiveness of substance abuse prevention programming: Towards making IOM program types comparable’, The Journal of Primary Prevention, 30, 89–107.

    Article  PubMed  Google Scholar 

  • Shukla, S., Kavak, E., Gregory, M., Imashimizu, M., Shutinoski, B., Kashlev, M., … Oberdoerffer, S. (2011). ‘CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing’, Nature, 479, 74–9.

    Article  PubMed  Google Scholar 

  • Slotkin, T. A. (1998). ‘Fetal nicotine or cocaine exposure: Which one is worse?’, Journal of Pharmacology and Experimental Therapeutics, 285, 931–45.

    PubMed  Google Scholar 

  • Stone, A. L., Becker, L. G., Huber, A. M., & Catalano, R. F. (2012). ‘Review of risk and protective factors of substance use and problem use in emerging adulthood’, Addictive Behaviors, 37, 747–75.

    Article  PubMed  Google Scholar 

  • Substance Abuse and Mental Health Services Administration (2013). Results from the 2012 national survey on drug use and health: Summary of national findings. (NSDUH Series H-46, HHS Publication No. [SMA] 13–4795). Rockville, MD: Substance Abuse and Mental Health Services Administration.

    Google Scholar 

  • Syme, C., Abrahamowicz, M., Mahboubi, A., Leonard, G. T., Perron, M., Richer, L., … Pausova, Z. (2010). ‘Prenatal exposure to maternal cigarette smoking and accumulation of intra-abdominal fat during adolescence’, Obesity (Silver Spring), 18, 1021–5.

    Article  Google Scholar 

  • Taha, S. A. (2010). ‘Preference or fat? Revisiting opioid effects on food intake’, Physiology & Behavior, 100, 429–37.

    Article  Google Scholar 

  • Terry, M. B., Ferris, J. S., Pilsner, R., Flom, J. D., Tehranifar, P., Santella, R. M., … Susser, E. (2008). ‘Genomic DNA methylation among women in a multiethnic New York City birth cohort’, Cancer Epidemiology, Biomarkers & Prevention, 17, 2306–10.

    Article  Google Scholar 

  • Toledo-Rodriguez, M., Lotfipour, S., Leonard, G., Perron, M., Richer, L., Veillette, S., … Paus, T. (2010). ‘Maternal smoking during pregnancy is associated with epigenetic modifications of the brain-derived neurotrophic factor-6 exon in adolescent offspring’, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 153B, 1350–4.

    Article  Google Scholar 

  • Toro, R., Leonard, G., Lerner, J. V., Lerner, R. M., Perron, M., Pike, G. B., … Paus, T. (2008). ‘Prenatal exposure to maternal cigarette smoking and the adolescent cerebral cortex’, Neuropsychopharmacology, 33, 1019–27.

    Article  PubMed  Google Scholar 

  • Tucker, L. A., Seljaas, G. T, & Hager, R. L. (1997). ‘Body fat percentage of children varies according to their diet composition’, Journal of the American Dietetic Association, 97, 981–6.

    Article  PubMed  Google Scholar 

  • von Kries, R., Toschke, A. M., Koletzko, B., & Slikker Jr., W. (2002). ‘Maternal smoking during pregnancy and childhood obesity’, American Journal of Epidemiology, 156, 954–61.

    Article  Google Scholar 

  • Wakschlag, L. S., Henry, D. B., Blair, R. J., Dukic, V., Burns, J., & Pickett, K. E. (2011). ‘Unpacking the association: Individual differences in the relation of prenatal exposure to cigarettes and disruptive behavior phenotypes’, Neurotoxicology and Teratology, 33, 145–54.

    Article  PubMed  PubMed Central  Google Scholar 

  • Wang, T., Chen, M., Liu, L., Cheng, H., Yan, Y E., Feng, Y H., & Wang, H. (2011). ‘Nicotine induced CpG methylation of Pax6 binding motif in stAR promoter reduces the gene expression and Cortisol production’, Toxicology and Applied Pharmacology, 257, 328–37.

    Article  PubMed  PubMed Central  Google Scholar 

  • Weng, S. F., Redsell, S. A., Swift, J. A., Yang, M., & Glazebrook, C. P. (2012). ‘Systematic review and meta-analyses of risk factors for childhood overweight identifiable during infancy’, Archives of Disease in Childhood, 97, 1019–26.

    Article  PubMed  PubMed Central  Google Scholar 

  • Whiteford, H. A., Degenhardt, L., Rehm, J., Baxter, A. J., Ferrari, A. J., Erskine, H. E., … Vos, T. (2013). ‘Global burden of disease attributable to mental and substance use disorders: Findings from the global burden of disease study 2010’, The Lancet, 382, 1575–86.

    Article  Google Scholar 

  • Wojnar, M., Brower, K.J., Strobbe, S., Ilgen, M., Matsumoto, H., Nowosad, I., … Burmeister, M. (2009). ‘Association between Val66Met brain-derived neurotrophic factor (BDNF) gene polymorphism and post-treatment relapse in alcohol dependence’, Alcoholism: Clinical and Experimental Research, 33, 693–702.

    Article  Google Scholar 

  • Zhang, M., Gosnell, B. A., & Kelley, A. E. (1998). ‘Intake of high-fat food is selectively enhanced by mu opioid receptor stimulation within the nucleus accumbens’, Journal of Pharmacology and Experimental Therapeutics, 285, 908–14.

    PubMed  Google Scholar 

  • Zheng, H., Townsend, R. L., Shin, A. C., Patterson, L. M., Phifer, C. B., & Berthoud, H. R. (2010). ‘High-fat intake induced by mu-opioid activation of the nucleus accumbens is inhibited by Y1R-blockade and MC3/4R- stimulation’, Brain Research, 1350, 131–8.

    Article  PubMed  PubMed Central  Google Scholar 

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Authors
  1. Tomáš Paus
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  2. Zdenka Pausova
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Editor information

Editors and Affiliations

  1. Oregon Health & Science University, USA

    Sarah W. Feldstein Ewing (Associate Professor) (Associate Professor)

  2. University of New Mexico, USA

    Katie Witkiewitz (Associate Professor) (Associate Professor)

  3. Center for Brain Health, University of Texas-Dallas, USA

    Francesca M. Filbey (Associate Professor) (Associate Professor)

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© 2015 Tomáš Paus and Zdenka Pausova

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Paus, T., Pausova, Z. (2015). Prenatal Exposure to Maternal Cigarette Smoking, Addiction, and the Offspring Brain. In: Ewing, S.W.F., Witkiewitz, K., Filbey, F.M. (eds) Neuroimaging and Psychosocial Addiction Treatment. Palgrave Macmillan, London. https://doi.org/10.1057/9781137362650_14

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