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Foul Farms: The State of Animal Agriculture

  • Aysha Akhtar
Chapter
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Part of the The Palgrave Macmillan Animal Ethics Series book series (PMAES)

Abstract

As disturbing as the wildlife trade is in fostering the development of new infectious diseases, recent events suggest that the biggest and most imminent threat may lie much closer to home. Between 2007 and 2008, farmers in the Philippines noticed that pigs were falling sick and dying by the hundreds for unknown reasons.1 A subsequent investigation confirmed the presence of porcine reproductive and respiratory disease syndrome, a serious illness among pigs.2 But, much to the surprise of the investigators, a subtype of Ebola virus, Ebola Reston, was also discovered circulating in a sample of the pigs. This was the first time Ebola of any strain had been found in these animals. ‘We never thought that pigs could be infected,’ says Pierre Rollin, an Ebola expert at the Centers for Disease Control and Prevention (CDC).3 Rollin believes that Ebola Reston is to blame for the pigs’ deaths because tissue studies revealed that the virus had pervaded the spleen, similar to its mode of attack in monkeys. Ebola Reston is named after the strain that was discovered in monkeys shipped to laboratories in the USA from the Philippines on several occasions between 1989 and 1996. The first shipment of Ebola virus was discovered after hundreds of monkeys became severely ill or died in a quarantine facility owned by Hazleton Laboratories (now Covance, Inc.) in Reston, Virginia.

Keywords

Necrotizing Fasciitis Foodborne Illness Domestic Bird Factory Farm H5N1 Outbreak 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Notes

  1. 1.
    Barrette RW, Metwally SA, Rowland JM et al. ‘Discovery of swine as a host for the Reston ebolavirusScience 2009; 325: 204–206;CrossRefGoogle Scholar
  2. Normille D. ‘Scientists puzzle over Ebola-Reston virus in pigs’ Science 2009; 323: 451;CrossRefGoogle Scholar
  3. Cyranoski D. ‘Ebola outbreak has experts rooting for answers’ Nature 2009; 457: 364–365.CrossRefGoogle Scholar
  4. 5.
    Popkin BM, Du S. ‘Dynamics of the nutrition transition toward the animal foods sector in China and its implications: A worried perspective’ Journal of Nutrition 2003; 133: 3898S–3906S;Google Scholar
  5. McMichael AJ, Powles JW, Butler CD, Uauy R. ‘Food, livestock production, energy, climate change and health’ Lancet 2007; 370: 1253–1263.CrossRefGoogle Scholar
  6. 7.
    Sorensen JT, Edwards S, Noordhuizen J, Gunnarsson S. ‘Animal production systems in the industrialised world’ Rev & Tech. 2006; 25:493–503.Google Scholar
  7. 8.
    Akhtar AZ, Greger M, Ferdowsian H, Frank E. ‘Health professionals’ roles in animal agriculture, climate change, and human health’ American Journal of Preventive Medicine 2009; 36: 182–187.CrossRefGoogle Scholar
  8. 9.
    Jonathan Safran Foer, Eating Animals (New York: Little, Brown & Company) 2009.Google Scholar
  9. 12.
    Leibler JH, Otte J, Roland-Holst D et al. ‘Industrial food animal production and global health risks: Exploring the ecosystems and economics of avian influenza’ EcoHealth 2009; 6: 58–70.CrossRefGoogle Scholar
  10. 18.
    Greger M (a). ‘The human/animal interface: Emergence and resurgence of zoonotic infectious diseases’ Critical Reviews in Microbiology 2007; 33: 243–299.CrossRefGoogle Scholar
  11. 19.
    Kestin SC, Knowles TG, Tinch AE, Gregory NG. ‘Prevalence of leg weakness in broiler chick and its relationship with genotype’ The Veterinary Record 1992; 131: 190–194;CrossRefGoogle Scholar
  12. Duncan IJH. ‘Welfare problems of meat-type chickens’ Farmed Animal Well-Being Conference at the University of California-Davis, June 28–29, 2001; Knowles TG, Kestin SC, Haslam SM et al. ‘Leg disorders in broiler chickens: Prevalence, risk factors and prevention’ Public Library of Science ONE 2008; 3 (2): e1545. doi: 10.1371/journal.pone.0001545. Google Scholar
  13. 20.
    Grandin T, Johnson C. Animals in Translation (New York: Scribner) 2005, pp. 270–271.Google Scholar
  14. 21.
    United Egg Producers. ‘Housing, space, feed and water’ 2009. www.uepcertified.com, date accessed December 11, 2010; Greger (a), 2007; Fraser D, Mench J, Millman S. ‘Farm animals and their welfare in 2000’ in Salem DJ, Row AN (ed.), State of the Animals (Washington, DC: Humane Society Press) 2001, pp. 87–99.Google Scholar
  15. 36.
    Greger M (b). ‘The long haul: Risks associated with livestock transport’ Biosecurity and Bioterrorism: Biodefense Strategy, Practice and Science 2007; 5: 301–311.CrossRefGoogle Scholar
  16. 37.
    Food and Agriculture Organization of the United Nations. Guidelines for Humane Handling, Transport and Slaughter of Livestock (Bangkok: FAO) 2001. www.fao.org/, date accessed December 9, 2010.Google Scholar
  17. 40.
    Gilchrist MJ, Greko C, Wallinga DB, Beran GW, Riley DG, Thorne PS. ‘The potential role of concentrated animal feeding operations in infectious disease epidemics and antibiotic resistance’ Environmental Health Perspectives 2007; 115: 313–316.CrossRefGoogle Scholar
  18. 43.
    Mulder R. ‘Impact of transport and related stresses on the incidence and extent of human pathogens in pigmeat and poultry’ Journal of Food Safety 1995; 15: 239–246.CrossRefGoogle Scholar
  19. 44.
    Greger (a), 2007; Tuyttens FAM. ‘The importance of straw for pigs and cattle welfare: A review’ Applied Animal Behaviour Science 2005; 92: 261–282; Mulder, 1995.CrossRefGoogle Scholar
  20. 47.
    Whyte P, Collins JD, McGill K, Monahan C, O’Mahony H. ‘The effect of transportation stress on excretion rates of Campylobacters in market-age broilers’ Poultry Science 2001; 80: 817–820;CrossRefGoogle Scholar
  21. Marg H, Scholz HC, Arnold T, Rosler U, Hensel A. ‘Influence of long-time transportation stress on reactivation of Salmonella typhimurium DT 104 in experimentally infected pigs’ Berliner und Munchener Tierarztliche Wochenschrift 2001; 114: 385–388.Google Scholar
  22. 48.
    Barham AR, Barham BL, Johnson AK et al. ‘Effects of the transportation of beef cattle from the feedyard to the packing plant on prevalence levels of Escherichia coli 0157 and Salmonella spp’ Journal of Food Protection 2002; 65: 280–283.Google Scholar
  23. 51.
    Shackelford AD. ‘Modifications of processing methods to control SalmonellaPoultry Science 1988; 67: 933–935.CrossRefGoogle Scholar
  24. 53.
    Cole DJ, Hill VR, Humenik FJ, Sobsey MD. ‘Health, safety, and environmental concerns of farm animal waste’ Occupational Medicine: State of the Arts Reviews 1999; 14: 423–428;Google Scholar
  25. Mitloehner FM, Schenker MB. ‘Environmental exposure and health effects from concentrated animal feeding operations’ Epidemiology 2007; 18: 309–311;CrossRefGoogle Scholar
  26. Just N, Duchaine C, Singh B. ‘An aer-obiological perspective of dust in caged-house and floor housed poultry operations’ Journal of Occupational Medicine and Toxicology 2009; 4: 13.CrossRefGoogle Scholar
  27. 54.
    Mitloehner and Schenker, 2007; Thu KM. ‘Public health concerns for neighbors of large-scale swine operations’ Journal of Agricultural Safety and Health 2002; 8: 175–184;CrossRefGoogle Scholar
  28. Greger M, Koneswaran G. ‘The public health impacts of concentrated animal feeding operations on local communities’ Fam Community Health 2010; 33: 11–20; Just et al., 2009.CrossRefGoogle Scholar
  29. 60.
    Mead PS, Slutsker L, Dietz V et al. ‘Food-related illness and death in the United States’ Emerging Infectious Diseases 1999; 5: 607–625;CrossRefGoogle Scholar
  30. Chittick P, Sulka A, Tauxe RC, Fry AM. ‘A summary of national reports of foodborne outbreaks of Salmonella Heidelberg infections in the United States: Clues for disease prevention’ Journal of Food Protection 2006; 69; 1150–1153.Google Scholar
  31. 61.
    Leirisalo-Repo M, Helenius P, Hannu T et al. ‘Long-term prognosis of reactive salmonella arthritis’ Annals of the Rheumatic Diseases 1997; 56: 516–520.CrossRefGoogle Scholar
  32. 64.
    Van Hoorebeke S , Van Immerseel FV, Schulz J et al. (a). ‘Determination of the within and between flock prevalence and identification of risk factors for Salmonella infections in laying hen flocks housed in conventional and alternative systems’ Preventive Veterinary medicine 2010; 94; 94–100;CrossRefGoogle Scholar
  33. Methner U, Diller R, Reiche R, Bohland K. ‘Occurrence of salmonellae in laying hens in different housing systems and inferences for control’ Berl Munch Tieraztl Wochenschr 2006; 119: 467–473;Google Scholar
  34. De Vylder J, Van Hoorebeke S, Ducatelle R et al. ‘Effect of the housing system on shedding and colonization of gut and internal organs of laying hens with Salmonella enteritidisPoultry Science 2009; 88: 2491–2495;CrossRefGoogle Scholar
  35. Snow LC, Davies RH, Christiansen KH et al. ‘Survey of the prevalence of Salmonella species on commercial laying farms in the United Kingdom’ The Veterinary Record 2007; 161: 471–476;CrossRefGoogle Scholar
  36. Huneau-Salaün A, Chemaly M, Le Bouquin S et al. ‘Risk factors for Salmonella enterica subsp. enterica contamination in 519 French laying hen flocks at the end of the laying period’ Preventive Veterinary Medicine 2009; 89: 51–58;CrossRefGoogle Scholar
  37. Namata H, Méroc E ,Aerts et al. ‘Salmonella in Belgian laying hens: An identification of risk factors’ Preventive Veterinary Medicine 2008; 83: 323–336;CrossRefGoogle Scholar
  38. Mahé A, Bougeard S, Huneau-Salaün A et al. ‘Bayesian estimation of flock-level sensitivity of detection of Salmonella spp., Enteriditis and Typhimurium according to the sampling procedure in French laying-hen houses’ Preventive Veterinary Medicine 2008; 84: 11–26;CrossRefGoogle Scholar
  39. Snow LC, Davies RH, Christiansen KH et al. ‘Investigation of risk factors for Salmonella on commercial egg-laying farms in Great Britain, 2004–2005’ The Veterinary Record 2010; 166: 579–586.CrossRefGoogle Scholar
  40. 65.
    Namata et al., 2008; Davies R, Breslin M. ‘Observations on Salmonella contamination of commercial laying farms before and after cleaning and disinfection’ The Veterinary Record 2003; 152: 283–287.CrossRefGoogle Scholar
  41. 66.
    Ibid.; Olsen AR, Hammack TS. ‘Isolation of Salmonella spp. from the housefly, Musca domestica L., and the dump fly Hydrotaea aenescens (Wiedemann) (Diptera: Muscidae), at caged-layer houses’ Journal of Food Protection 2000; 63: 958–960;Google Scholar
  42. Winpisinger KA, Ferketich AK, Berry RL, Moeschberger ML. ‘Spread of Musca domestica (Diptera: muscidae), from two caged layer facilities to neighboring residences in rural Ohio’ Journal of Medical Entomology 2005; 42: 732–738;CrossRefGoogle Scholar
  43. Garber L, Smeltzer M, Fedorka-Cray P, Ladely S, Ferris K. ‘Salmonella enterica subtype serotype Enteritidis in table egg layer house environments and in mice in U.S. layer houses and associated risk factors’ Avian Diseases 2003; 47: 134–142; Van Hoorebeke S, Van Immerseel F, Haesebrouck F, Ducatelle R, Dewulf J (b). ‘The influence of the housing system on Salmonella infections in laying hens: A review’ Zoonoses and Public Health September 28, 2010. doi: 10.1111/j.l863–2378.2010.01372.x. (epub ahead of print).CrossRefGoogle Scholar
  44. 69.
    Centers for Disease Control and Prevention (CDC). ‘Preliminary FoodNet data on the incidence of infection with pathogens transmitted commonly through food—10 states, United States, 2005’ Morbidity and Mortality Weekly Report 2006; 55: 392–395.Google Scholar
  45. 70.
    Nakamura M, Nagamine N, Takahashi T et al. ‘Horizontal transmission of Salmonella enteritidis and effect of stress on shedding in laying hens’ Avian Diseases 1994; 38: 282–288.CrossRefGoogle Scholar
  46. 72.
    Sarwari AR, Magder LS, Levine P et al. ‘Serotype distribution of Salmonella isolates from food animals after slaughter differs from that of isolates found in humans’ Journal of Infectious Diseases 2001; 183: 1295–1299.CrossRefGoogle Scholar
  47. 73.
    Poppe C, Irwin RJ, Forsberg CM, Clarke RC, Oggel J. ‘The prevalence of Salmonella enteritidis and other Salmonella spp. among Canadian registered commercial layer flocks’ Epidemiology and Infection 1991; 106: 259–270;CrossRefGoogle Scholar
  48. Poppe C, Irwin RJ, Messier S, Finley GG, Oggel J. ‘The prevalence of Salmonella enteritidis and other Salmonella spp. among Canadian registered commercial broiler flocks’ Epidemiology and Infection 1991; 107: 201–211.CrossRefGoogle Scholar
  49. 74.
    Maes D, Deluyker H, Verdonck M et al. ‘Herd factors associated with the seroprevalences of four major respiratory pathogens in slaughter pigs from farrow-to-finish pig herds’ Veterinary Research 2000; 31: 313–327;CrossRefGoogle Scholar
  50. Jones PW, Colins P, Brown GT, Aitken MM. ‘Salmonella saint-paul infection in two dairy herds’ Journal of Hygiene 1983; 91: 243–257;CrossRefGoogle Scholar
  51. Lanada EB, Morris RS, Jackson R, Fenwick SG, Verdonck M et al. ‘Herd factors associated with the seroprevalences of four major respiratory pathogens in slaughter pigs from farrow-to-finish pig herds’ Veterinary Research 2000; 31: 313–327;CrossRefGoogle Scholar
  52. Jones PW, Colins P, Brown GT, Aitken MM. ‘Salmonella saint-paul infection in two dairy herds’ Journal of Hygiene 1983; 91: 243–257;CrossRefGoogle Scholar
  53. Lanada EB, Morris RS, Jackson R, Fenwick SG. ‘Prevalence of Yersinia species in goat flocks’ Australian Veterinary Journal 2005; 83: 563–566;CrossRefGoogle Scholar
  54. Salman MD, Meyer ME. ‘Epidemiology of bovine brucellosis in the Mexicali Valley, Mexico: Literature review of disease-associated factors’ American Journal of Veterinary Research 1984; 45: 1557–1560;Google Scholar
  55. Atwill ER, Johnson EM, Pereira MG. ‘Association of herd composition, stocking rate, and duration of calving season with fecal shedding of Cryptosporidium parvum oocysts in beef herds’ Journal of the American Veterinary Medical Association 1999; 215: 1833–1838;Google Scholar
  56. Stacey KF, Parsons DJ, Christiansen KH, Burton CH. ‘Assessing the effect of interventions on the risk of cattle and sheep carrying Escherichia coli 0157:H7 to the abbatoir using a stochastic model’ Preventive Veterinary Medicine 2007; 79: 32–45.CrossRefGoogle Scholar
  57. 75.
    Withers MR, Correa MT, Morrow M et al. ‘Antibody levels to hepatitis E virus in North Carolina swine workers, non-swine workers, swine and murids’ American Journal of Tropical Medicine and Hygiene 2002; 66: 384–388;Google Scholar
  58. Olsen B, Axelsson-Olsson D, Thelin A, Weiland O. ‘Unexpected high prevalence of IgG-antibodies to hepatitis E virus in Swedish pig farmers and controls’ Scandinavian Journal of Infectious Diseases 2006; 38: 55–58;CrossRefGoogle Scholar
  59. Olsen CW, Brammer L, Easterday BC et al. ‘Serologic evidence of Hlswine influenza virus in swine farm residents and employees’ Emerging Infectious Diseases 2002; 8: 814–819;CrossRefGoogle Scholar
  60. Fey PD, Safranek TJ, Rupp ME et al. ‘Ceftriaxone-resistant salmonella infection acquired by a child from cattle’ New England Journal of Medicine 2000; 342: 1242–1249;CrossRefGoogle Scholar
  61. van den Bogaard AE, London N, Criessen C, Stobberingh EE. ‘Antibiotic resistance of faecal Escherichia coli in poultry, poultry farmers and poultry slaughterers’ Journal of Antimicrobial Chemotherapy 2001; 47: 763–771;CrossRefGoogle Scholar
  62. van den Bogaard AE, Willems R, London N, Top J, Stobberingh EE. ‘Antibiotic resistance of faecal enterococci in poultry, poultry farmers and poultry slaughterers’ Journal of Antimicrobial Chemotherapy 2002; 49: 497–505;CrossRefGoogle Scholar
  63. Gray GC, Baker WS. ‘The importance of including swine and poultry workers in influenza vaccination programs’ Clinical Pharmacology & Therapeutics 2007; 82: 638–641.CrossRefGoogle Scholar
  64. 76.
    Myers KP, Olsen CW, Setterquist SF et al. ‘Are swine workers in the United States at increased risk of infection with zoonotic influenza virus?’ Clinical Infectious Diseases 2006; 42: 14–20;CrossRefGoogle Scholar
  65. Cole D, Todd L, Wing S. ‘Concentrated swine feeding operations and public health: A review of occupational and community health effects’ Environmental Health Perspectives 2000; 108; 685–699.CrossRefGoogle Scholar
  66. 77.
    Miliner PD. ‘Bioaerosols associated with animal production operations’ Bioresource Technology 2009; 100: 5379–5385.CrossRefGoogle Scholar
  67. 78.
    Green CF, Gibbs SG, Tarwater PM, Mota LC, Scarpino PV. ‘Bacterial plume emanating from the air surrounding swine confinement operations’ Journal of Occupational Environmental Hygiene 2006; 3: 9–15; Millner, 2009.CrossRefGoogle Scholar
  68. 81.
    Gibbs SG, Green CF, Tarwater PM, Scarpino PV. ‘Airborne antibiotic resistant and nonresistant bacteria and fungi recovered from two swine herd confined animal feeding operations’ Journal of Occupational Environmental Hygiene 2004; 1: 699–706;CrossRefGoogle Scholar
  69. Gibbs SG, Green CF, Tarwater PM et al. ‘Isolation of antibiotic-resistant bacteria from the air plume downwind of a swine confined or concentrated feeding operation’ Environmental Health Perspective 2006; 114: 1032–1037;CrossRefGoogle Scholar
  70. Ko G, Simmons III OD, Likirdopulos CA, Worley-Davis L, Williams M, Sobsey MD. ‘Investigation of bioaerosols released from swine farms using conventional and alternative waste treatment and management technologies’ Environmental Science and Technology 2008; 42: 8849–8857.CrossRefGoogle Scholar
  71. 82.
    Waltner-Toews D, Lang T ‘A new conceptual base for food and agricultural policy: The emerging model of links between agriculture, food, health, environment and society’ Global Change and Human Health 2000; 1, 116–130.CrossRefGoogle Scholar
  72. 83.
    Tauxe RV. ‘Emerging foodborne pathogens’ International Journal of Food Microbiology 2002; 78: 31–41; Mead et al., 1999.CrossRefGoogle Scholar
  73. 85.
    Adams M, Motarjemi Y. Basic Food Safety for Health Workers (Geneva: WHO Press) 1999;Google Scholar
  74. McMichael AJ, Haines A, Slooff R, Kovats S (eds), Climate Change and Human Health (Geneva: WHO, World Meteorological Organization, United States Environmental Program) 1996;Google Scholar
  75. Lederberg J, Shope RE, Oaks SC. Emerging Infections: Microbial Threats to Health in the United States (Washington, DC: National Academies Press) 1992, p. 15.Google Scholar
  76. 86.
    Johnson JR, Kuskowski MA, Smith K, O’Bryan TT, Tatini S. ‘Antimicrobial-resistant and extraintestinal pathogenic Escherichia coli in retail foods’ Journal of Infectious Diseases 2005; 191:1040–1049.CrossRefGoogle Scholar
  77. 88.
    McCarthy N, Giesecke J. ‘Incidence of Guillan-Barre Syndrome following infection with Campylobacter jejuniAmerican Journal of Epidemiology 2001; 153: 610–614.CrossRefGoogle Scholar
  78. 89.
    Spencer JL, Guan J. ‘Public health implications related to spread of pathogens in manure from livestock and poultry operations’ Methods in Molecular Biology 2004; 268: 503–515.Google Scholar
  79. 91.
    Martinez J, Dabert P, Barrington S, Burton C. ‘Livestock waste treatment systems for environmental quality, food safety, and sustainability’ Bioresource Technology 2009; 100: 5527–5536.CrossRefGoogle Scholar
  80. 93.
    Gerba CP, Smith JE. ‘Sources of pathogenic microorganisms and their fate during land application of wastes’ Journal of Environmental Quality 2005; 34: 42–48; Ed Ayres, ‘Will we still eat meat?’ Time Magazine November 8, 1999.Google Scholar
  81. 95.
    Graham JP, Leibler JH, Price LB et al. ‘The animal-human interface and infectious disease in industrial food animal production: Rethinking biosecurity and biocontainment’ Public Health Reports 2008; 123: 282–299.Google Scholar
  82. 96.
    Wing S, Freedman S, Band L. ‘The potential impact of flooding on confined animal feeding operations in Eastern North Carolina’ Environmental Health Perspectives 2002; 110: 387–391.CrossRefGoogle Scholar
  83. 101.
    Xiao L, Moore JE, Ukoh U et al. ‘Prevalence and identity of Cryptosporidium spp. in pig slurry’ Applied and Environmental Microbiology 2006; 72: 4461–4463.CrossRefGoogle Scholar
  84. 105.
    Riemann H, Himathongkham S, Willoughby D, Tarbell R, Breitmeyer R. ‘A survey for Salmonella by drag swabbing manure piles in California egg ranches’ Avian Diseases 1998; 42: 67–71.CrossRefGoogle Scholar
  85. 106.
    Guan and Holley, 2003; Himathongkham S, Bahari S, Riemann H, Cliver D. ‘Survival of Escherichia coli 0157:H7 and Salmonella typhimurium in cow manure and cow manure slurry’ FEMS Microbiology Letters 1999; 178: 251–257.CrossRefGoogle Scholar
  86. 111.
    Pell AN. ‘Manure and microbes: Public and animal health problem?’ Journal of Dairy Science 1997; 80: 2673–2681.CrossRefGoogle Scholar
  87. 112.
    Tauxe, 2002; Chemaly M, Toquin M-T, le Nôtre Y, Fravalo P. ‘Prevalence of Listeria monocytogenes in poultry production in France’ Journal of Food Protection 2008; 71: 1996–2000.Google Scholar
  88. 115.
    Guo X, Chen J, Brackett RE, Beauchat LR. ‘Survival of salmonellae on and in tomato plants from the time of inoculation at flowering and early stages of fruit development through fruit ripening’ Applied and Environmental Microbiology 2001; 67: 4760–4764.CrossRefGoogle Scholar
  89. 116.
    Michino H, Araki K, Minami S et al. ‘Massive outbreak of Escherichia coli 0157:H7 infection in school children in Sakai City Japan, associated with consumption of white radish sprouts’ American Journal of Epidemiology 1999; 150: 787–796.CrossRefGoogle Scholar
  90. 120.
    Valcour JE, Michel P, McEwen SA, Wilson JB. ‘Associations between indicators of livestock farming intensity and incidence of human Shiga toxin-producing Escherichia coli infection’ Emerging Infectious Diseases 2002; 8: 252–257;CrossRefGoogle Scholar
  91. Kistemann T, Zimmer S, Vagsholm I, Andersson Y. ‘GIS-supported investigation of human EHEC and cattle VTEC 0157 infections in Sweden: Geographical distribution, spatial variation and possible risk factors’ Epidemiology and Infection 2004; 132: 495–505;CrossRefGoogle Scholar
  92. Haus-Cheymol R, Espie E, Che D et al. ‘Association between indicators of cattle density and incidence of paediatric haemolytic-ureamic syndrome (HUS) in children under 15 years of age in France between 1996 and 2001: An ecological study’ Epidemiology andlnfection 2005; 134: 1–7;Google Scholar
  93. Michel P, Wilson JB, Martin SW et al. ‘Temporal and geographical distributions of reported cases of Escherichia coli 0157:H7 infection in Ontario’ Epidemiology and Infection 1999; 122: 193–200;CrossRefGoogle Scholar
  94. Frank C, Kapfhammer S, Werber D, Stark K, Held L. ‘Cattle density and Shiga toxin-producing Escherichia coli infection in Germany: increased risk for most but not all serogroups’ Vector Borne and Zoonotic Diseases 2008; 8: 635–643.CrossRefGoogle Scholar
  95. 123.
    Tomasz A. ‘Multiple-antibiotic-resistant pathogenic bacteria—A report on the Rockefeller University Workshop’ New England Journal of Medicine 1994; 330: 1247–1251.CrossRefGoogle Scholar
  96. 126.
    Aarestrup FM, Duran CO, Burch DGS. ‘Antimicrobial resistance in swine production’ Animal Health Research Reviews 2008; 9: 135–148;CrossRefGoogle Scholar
  97. Gilchrist et al., 2007; Hughes P, Heritage J. ‘Antibiotic growth-promotors in food animals’ in Assessing Quality and Safety of Animal Feeds (Rome: Food and Agriculture Organization of the United Nations) 2004.Google Scholar
  98. 128.
    Office of Technology Assessment. Drugs in Livestock Feed. Volume 1: Technical Report (Washington, DC: US Government Printing Office) 1979, p. 41. www.princeton.edu, date accessed November 21, 2010.Google Scholar
  99. 132.
    Mellon M, Benbrook C, Benbrook KL. Hogging It! Estimates of Antimicrobial Abuse in Livestock (Cambridge, MA: Union of Concerned Scientists) 2001.Google Scholar
  100. 135.
    Perkin RM, Swift JD, Newton DA, Anas NG. (eds) Hospital Medicine Textbook of Inpatient Medicine, 2nd edn. (Philadelphia, PA: Lippincott, Williams, & Wilkins) 2008, p. 450.Google Scholar
  101. 137.
    Smith TC, Male MJ, Harper AL et al. (a). ‘Methicillin-resistant Staphylococcus aureus (MRSA) strain ST398 is present in Midwestern U.S. swine and swine workers’ Public Library of Science One 2009; 4 (1): e4258. doi: 10.1371/journal.pone.0004258 Google Scholar
  102. 138.
    Kuehn BM. ‘Antibiotic-resistant “superbugs” may be transmitted from animals to humans’ Journal of the American Medical Association 2007; 298: 2125–2126;CrossRefGoogle Scholar
  103. Levy SB, Fitzgerald GB, Macone AB. ‘Changes in intestinal flora of farm personnel after introduction of a tetracycline-supplemented feed on a farm’ New England Journal of Medicine 1976; 295: 538–588.CrossRefGoogle Scholar
  104. 139.
    Gibbs et al., 2006; Gibbs et al., 2004; Campagnolo ER, Johnson KR, Karpati A et al. ‘Antimicrobial residues in animal waste and water resources proximal to large-scale swine and poultry feeding operations’ Science of the Total Environment 2002; 299: 89–95;CrossRefGoogle Scholar
  105. Price LB, Graham JP, Lackey LG et al. ‘Elevated risk of carrying gentamicin-resistant Escherichia coli among U.S. poultry workers’ Environmental Health Perspectives 2007; 115: 1738–1742;CrossRefGoogle Scholar
  106. Yang H, Dettman B, Beam J, Mix C, Jiang X. ‘Occurrence of ceftriaxone-resistant commensal bacteria on a dairy farm and a poultry farm’ Canadian Journal of Microbiology 2006; 52: 942–950;Google Scholar
  107. Siegel D, Huber WG, Enloe E ‘Continuous non-therapeutic use of antibacterial drugs in feed and drug resistance of the gram-negative enteric florae of food-producing animals’ Antimicrobial Agents and Chemotherapy 1974; 6: 697–701;CrossRefGoogle Scholar
  108. Nógrády N, Kardos G, Bistyák A et al. ‘Prevalence and characterization of Salmonella infantis isolates originating from different points of the broiler chicken-human food chain in Hungary’ International Journal of Food Microbiology 2008; 127: 162–167;CrossRefGoogle Scholar
  109. Amyes SG. ‘Trimethoprim resistance in commensal bacteria isolated from farm animals’ Epidemiology and Infection 1987; 98: 87–96;CrossRefGoogle Scholar
  110. Ghosh S, LaPara TM. ‘The effects of subtherapeutic antibiotic use in farm animals on the proliferation and persistence of antibiotic resistance among soil bacteria’ Intenational Society for Microbial Ecology Journal 2007; 1: 191–203;Google Scholar
  111. Welch B, Forsberg CW. ‘Chlortetracycline and sulfonamide resistance of fecal bacteria in swine receiving medicated feed’ Canadian Journal of Microbiology 1979; 25: 789–792;CrossRefGoogle Scholar
  112. Smith HW, Lovell MA. ‘Escherichia coli resistant to tetracyclines and to other antibiotics in the faeces of U.K. chickens and pigs in 1980’ Journal of Hygiene (London) 1981; 87: 477–483;CrossRefGoogle Scholar
  113. Sayah RS, Kaneene JB, Johnson Y, Miller R. ‘Patterns of antimicrobial resistance observed in Escherichia coli isolates obtained from domestic- and wild-animal fecal samples, human septage, and surface water’ Applied and Environmental Microbiology 2005; 71: 1394–1404.CrossRefGoogle Scholar
  114. 140.
    Graham JP, Price LB, Evans SL, Graczyk TK, Silbergeld EK. ‘Antibiotic resistant enterococci and staphylococci isolated from flies collected near confined poultry feeding operations’ Science of the Total Environment 2009; 407: 2701–2710.CrossRefGoogle Scholar
  115. 142.
    Akwar TH, Poppe C, Wilson J et al. ‘Risk factors for antimicrobial resistance among fecal Escherichia coli from residents on forty-three swine farms’ Microbial Drug Resistance 2007; 13: 69–76.CrossRefGoogle Scholar
  116. 143.
    Chapin A, Rule A, Gibson K, Buckley T, Schwab K. ‘Airborne multi-drug resistant bacteria isolated from a concentrated swine feeding operation’ Environmental Health Perspective 2005; 113: 137–142.Google Scholar
  117. 145.
    Johnson JR, Kuskowski MA, Smith K, O’Bryan TT, Tatini S. ‘Antimicrobial-resistant and extraintestinal pathogenic Escherichia coli in retail foods’ Journal of Infectious Disease 2005; 191: 1040–1049;CrossRefGoogle Scholar
  118. Manie T, Khan S, Brözel VS, Veith WJ, Gouws PA. ‘Antimicrobial resistance of bacteria isolated from slaughtered and retail chickens in South Africa’ Letters in Applied Microbiology 1998; 26: 253–258;CrossRefGoogle Scholar
  119. Nôgrâdy et al., 2008; Holmberg SD, Osterholm MT, Senger KA, Cohen ML. ‘Drug-resistant salmonella from animals fed antimicrobials’ New England Journal of Medicine 1984; 311: 617–622;CrossRefGoogle Scholar
  120. Spika JS, Wasterman SH, Soo Hoo GW et al. ‘Chloramphenicol-resistant Salmonella newport traced through hamburger to dairy farms’ New England Journal of Medicine 1987; 316: 565–570;CrossRefGoogle Scholar
  121. Smith KE, Besser JM, Hedberg CW et al. ‘Quinolone-resistant Campylobacter jejuni infections in Minnesota, 1992–1998’ New England Journal of Medicine 1999; 340: 1525–1532;CrossRefGoogle Scholar
  122. Sanotra et al., 2001; Arnold S, Gassner B, Giger T, Zwahlen R. ‘Banning antimicrobial growth promoters in feedstuffs does not result in increased therapeutic use of antibiotics in medicated feed in pig farming’ Pharmacoepidemiology and Drug Safety 2004; 13: 323–331.CrossRefGoogle Scholar
  123. 147.
    Sapkota AR, Lefferts LY, McKenzie S, Walker P. ‘What do we feed to food-production animals? A review of animal feed ingredients and their potential impacts on human health’ Environmental Health Perspectives 2007; 115: 663–670; Smith et al., 1999.CrossRefGoogle Scholar
  124. 152.
    Treanor J. ‘Influenza vaccine—Outmaneuvering antigenic shift and drift’ New England Journal of Medicine 2004; 350: 218–220.CrossRefGoogle Scholar
  125. 153.
    Skeik N, Jabr FI. ‘Influenza viruses and the evolution of avian influenza virus H5N1’ International Journal of Infectious Diseases 2008; 12: 233–238.CrossRefGoogle Scholar
  126. 154.
    Webster RG, Bean WJ, Gorman OT, Chambers TM, Kawaoka Y. ‘Evolution and ecology of influenza A viruses’ Microbiological Reviews 1992; 56: 152–179.Google Scholar
  127. 156.
    Taubenberger JK, Morens DM. ‘1918 influenza: The mother of all pandemics’ Emerging Infectious Diseases 2006; 12: 15–22.CrossRefGoogle Scholar
  128. 157.
    Neumann G, Noda T, Kawaoka Y. ‘Emergence and pandemic potential of swine-origin H1N1 influenza virus’ Nature 2009; 459: 931–939; Taubenberger and Morens, 2006.CrossRefGoogle Scholar
  129. 159.
    Eagles D, Sireger ES, Dung DH, et al. ‘H5N1 highly pathogenic avian influenza in Southeast Asia’ Rev sci tech off int epiz 2009; 28: 341–348; World Health Organization (WHO). ‘H5N1 avian influenza: Timeline of major events, May 2, 2011.’ www.who.int, date accessed November 19, 2010.Google Scholar
  130. 161.
    Webby RJ, Webster RG. ‘Emergence of influenza A viruses’ Philosophical Transactions of the Royal Society of London B Biological Sciences 2001; 356: 1817–1828.CrossRefGoogle Scholar
  131. 162.
    Yee KS, Carpenter TE, Cardona CJ. ‘Epidemiology of H5N1 avian influenza’ Comparative Immunology, Microbiology and Infectious Diseases 2009; 32: 325–340.CrossRefGoogle Scholar
  132. 163.
    Ibid.; Peiris JSM, de Jong MD, Guan Y ‘Avian influenza virus (H5N1): A threat to human health’ Clinical Microbiology Reviews 2007; 20: 243–267.CrossRefGoogle Scholar
  133. 164.
    Capua I, Alexander DJ. ‘Animal and human health implications of avian influenza infections’ Bioscience Reports 2007; 27: 359–372.CrossRefGoogle Scholar
  134. 168.
    Peiris et al., 2007; Tiensin T, Sayeem S, Ahmed SU et al. ‘Ecologic risk factor investigation of clusters of Avian Influenza A (H5N1) virus infection in Thailand’ Journal of Infectious Diseases 2009; 199: 1735–1743.CrossRefGoogle Scholar
  135. 174.
    World Health Organization (WHO). ‘Current phase of alert in the WHO global influenza preparedness plan (avian influenza H5N1)’. www.who.int/, date accessed November 20, 2010; Martinot A, Thomas J, Thiermann A, Dasgupta N. ‘Prevention and control of avian influenza: The need for a paradigm shift in pandemic influenza preparedness’ The Veterinary Record 2007; 160: 343–345; WHO, ‘H5N1 avian influenza: Timeline’, 2011; Peiris et al., 2007.CrossRefGoogle Scholar
  136. 175.
    Iwami S, Takeuchi Y, Liu X. ‘Avian flu pandemic: Can we prevent it?’ Journal of Theoretical Biology 2009; 257: 181–190;Google Scholar
  137. Babakir-Mina M, Balestra E, Perno CF, Aquaro S. ‘Influenza virus A (H5N1): A pandemic risk?’ New Microbiologica 2007; 30: 65–77; WHO, ‘Statements of 2009’, 2009.Google Scholar
  138. 180.
    Peiris et al., 2007; Bavinck V, Bouma A, van Boven M et al. ‘The role of backyard flocks in the epidemic of highly pathogenic avian influenza virus (H7N7) in the Netherlands in 2003’ Preventive Veterinary Medicine 2009; 88: 247–254.CrossRefGoogle Scholar
  139. 191.
    Busani L, Valsecchi MG, Rossi E et al. ‘Risk factors for highly pathogenic H7N1 avian influenza virus infection in poultry during the 1999–2000 epidemic in Italy’ The Veterinary Journal 2009; 181: 171–177.CrossRefGoogle Scholar
  140. 200.
    Weingartl HM, Albrecht RA, Lager KM, et al. ‘Experimental infection of pigs with the human 1918 pandemic influenza virus’ Journal of Virology 2009; 83: 4287–4296.CrossRefGoogle Scholar
  141. 201.
    Zhou NN, Senne DA, Landgraf JS, et al. ‘Genetic reassortment of avian, swine, and human influenza A viruses in American pigs’ Journal of Virology 1999; 73: 8851–8856;Google Scholar
  142. Weingartl et al., 2009; Brown IH. ‘The epidemiology and evolution of influenza viruses in pigs’ Veterinary Microbiology 2000; 74: 29–46;CrossRefGoogle Scholar
  143. Pappaioanou M, Gramer M. ‘Lessons from pandemic H1N1 2009 to improve prevention, detection, and response to influenza pandemics from a one health perspective’ Institute for Laboratory Animal Research Journal 2010;51:268–280.CrossRefGoogle Scholar
  144. 202.
    Pappaioanou and Gramer, 2010; Wuethrich B. ‘Chasing the fickle swine flu’ Science 2003; 299: 1502–1505.CrossRefGoogle Scholar
  145. 203.
    Zhou NN, Senne DA, Landgraf JS et al. ‘Emergence of H3N2 reassortment influenza A virus in North American pigs’ Veterinary Microbiology 2000; 74: 47–58; Pappaioanou and Gramer, 2010; Wuethrich, 2003.CrossRefGoogle Scholar
  146. 204.
    Wuethrich, 2003; Weingartl et al., 2009; Pappaioanou and Gramer, 2010; Wertheim JO. ‘When pigs fly: The avian origin of “swine flu” Environmental Microbiology 2009; 11: 2191–2192.CrossRefGoogle Scholar
  147. 206.
    Webby RJ, Rossow K, Erickson G, Sims Y, Webster R. ‘Multiple lineages of antigenically and genetically diverse influenza A virus co-circulate in the United States swine population’ Virus Research 2004; 103: 67–73.CrossRefGoogle Scholar
  148. 208.
    Sinha NK, Roy A, Das B, Das S, Basik S. ‘Evolutionary complexities of swine flu H1N1 gene sequences of 2009’ Biochemical and Biophysical Research Communications 2009; 390: 349–351;CrossRefGoogle Scholar
  149. Wertheim, 2009; Girard MP, Tarn JS, Assossou OM, Kieny MP. ‘The 2009 A (H1N1) influenza virus pandemic: A review’ Vaccine 2010; 28: 4895–4902;CrossRefGoogle Scholar
  150. Garten RJ, Davis CT, Russell CA et al. ‘Antigenic and genetic characteristics of swine-origin 2009 A (H1N1) influenza viruses circulating in humans’ Science 2009; 325; 197–201;CrossRefGoogle Scholar
  151. Smith GJD, Vijaykrishna D, Bahl J et al. (b). ‘Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic’ Nature 2009; 459: 1122–1125.CrossRefGoogle Scholar
  152. 215.
    Saenz RA, Hethcote HW, Gray GC. ‘Confined animal feeding operations as amplifiers of influenza’ Vector-Borne and Zoonotic Diseases 2006; 6: 338–346; Myers et al., 2006; Olsen et al., 2002.CrossRefGoogle Scholar
  153. 216.
    Butler D. ‘Patchy pig monitoring may hide flu threat’ Nature 2009; 459: 894–895.CrossRefGoogle Scholar
  154. 218.
    Capua and Alexander, 2007; Yee et al., 2009; Nidom CA, Takano R, Yamada S et al. ‘Influenza A (H5N1) viruses from pigs, Indonesia’ Emerging Infectious Diseases 2010; 16: 1515–1523.CrossRefGoogle Scholar
  155. 225.
    Schmidt CW. ‘Swine CAFOs and novel H1N1 flu: Separating facts from fears’ Environmental Health Perspectives 2009; 117: A394–A401.CrossRefGoogle Scholar
  156. 231.
    Bull SA, Allen VM, Dominique G et al. ‘Sources of Campylobacter spp. colonized housed broiler flocks during rearing’ Applied and Environmental Microbiology 2006; 72: 645–652.CrossRefGoogle Scholar
  157. 242.
    Hafez MH, Arafa A, Abdelwhab EM et al. ‘Avian influenza H5N1 virus infections in vaccinated commercial and backyard poultry in Egypt’ Poultry Science 2010; 89: 1609–1613.CrossRefGoogle Scholar
  158. 244.
    Lee C-W, Senne DA, Suarez DL. ‘Effect of vaccine use in the evolution of Mexican lineage H5N2 avian influenza virus’ Journal of Virology 2004; 78: 8372–8381.CrossRefGoogle Scholar
  159. 247.
    Tomley FM, Shirley MW. ‘Livestock infectious diseases and zoonoses’ Philosophical Transactions of the Royal Society B Biological Sciences 2009; 364: 2637–2642.CrossRefGoogle Scholar
  160. 249.
    Normille D. ‘Flu virus research yields results but no magic bullet for pandemic’ Science 2008; 319: 1178–1179.CrossRefGoogle Scholar

Copyright information

© Aysha Akhtar 2012

Authors and Affiliations

  • Aysha Akhtar
    • 1
    • 2
  1. 1.Oxford Centre for Animal EthicsUK
  2. 2.US Food and Drug AdministrationNorth PotomacUSA

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